A5019909484- Bone and Joint Diseases
- Hip disorders and treatments
- Orthopedic Infections and Treatments
- Peroxisome Proliferator-Activated Receptors
- Rheumatoid Arthritis Research and Therapies
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- Nuclear Physics and Applications
- Polysaccharides and Plant Cell Walls
- Liver Disease Diagnosis and Treatment
- Seaweed-derived Bioactive Compounds
- Fusion materials and technologies
- Magnetic confinement fusion research
- Parvovirus B19 Infection Studies
- Patient Dignity and Privacy
- Carbohydrate Chemistry and Synthesis
- Nuclear Materials and Properties
- Cutaneous lymphoproliferative disorders research
- Boron Compounds in Chemistry
- Millimeter-Wave Propagation and Modeling
- Plant and Fungal Interactions Research
- Research Data Management Practices
- Scientific Computing and Data Management
- Telomeres, Telomerase, and Senescence
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2020-2025
Shandong University of Traditional Chinese Medicine
2019-2025
ShenZhen People’s Hospital
2024
Shenzhen University
2024
ENN (China)
2024
Guizhou Minzu University
2024
Guangxi Medical University
2018-2021
Second Xiangya Hospital of Central South University
2020
Central South University
2020
Nanjing Maternity and Child Health Care Hospital
2020
ENN Science and Technology Development Co., Ltd. (ENN) is committed to generating fusion energy in an environmentally friendly cost-effective manner, which requires abundant aneutronic fuel. Proton-boron (p-11B or p-B) considered ideal choice for this purpose. Recent studies have suggested that p-B fusion, although challenging, feasible based on new cross section data, provided a hot ion mode high wall reflection can be achieved reduce electron radiation loss. The beta good confinement of...
XuanLong-50 (EXL-50) is the first medium-size spherical torus (ST) in China, with toroidal field at major radius 50 cm around 0.5T. CS-free and non-inductive current drive via electron cyclotron resonance heating (ECRH) was main physics research issue for EXL-50. Discharges plasma currents of kA - 180 were routinely obtained EXL-50, flattop sustained up to or beyond 2 s. The effectiveness on EXL-50 as high 1 A/W low-density discharges using 28GHz ECRH alone power less than 200 kW. reached...
Rheumatoid arthritis (RA) is a common autoimmune disease, but its specific biological mechanisms, especially the link between metabolites and RA, have not been conclusively hypothesized. This study used Mendelian randomization (MR) analysis approach to assess association 1400 human blood risk of RA. Pooled statistics were as exposure factors genome-wide studies RA endpoints, MR was analyze relationship 2. Inverse-variance weighting (IVW) preferred method, 4 methods, MR-Egger weighted median...
Abstract Objective To investigate the correlation between atherogenic index of plasma (AIP), body mass (BMI), and sarcopenia in older adults China, to analyze predictive ability AIP BMI for sarcopenia. Methods This study utilized data from 2011–2015 CHARLS database (China Health Retirement Longitudinal Study, CHARLS), focusing on participants aged 60 years older. The cross-sectional analysis included 7,744 samples, with 2,398 group 5,346 non-sarcopenia group. In retrospective cohort study,...
Abstract Backgroud Plasma lipids and alcohol intake frequency have been reported to be associated with the risk of osteoarthritis (OA). However, it remains inconclusive whether plasma play a role in development OA. Methods The study employed comprehensive genome-wide association database identify independent genetic loci strongly linked frequency, which were used as instrumental variables. causal between lipids, OA was then analyzed using two-sample Mendelian randomization methods such...
Abstract Purpose Steroid-induced osteonecrosis of the femoral head (SONFH) is a refractory orthopaedic hip joint disease that occurs in young- and middle-aged people. Previous experimental studies have shown autophagy might be involved pathological process SONFH, but pathogenesis SONFH remains unclear. We aimed to identify validate key potential autophagy-related genes further illustrate mechanism through bioinformatics analysis. Methods The GSE123568 mRNA expression profile dataset,...
Steroid-induced osteonecrosis of the femoral head (SONFH) was a refractory orthopedic hip joint disease in young and middle-aged people, but pathogenesis SONFH remained unclear. We aimed to identify potential genes screen therapeutic compounds for SONFH.The microarray obtained blood tissue from GEO database, then it identifies differentially expressed (DEGs). The DEGs were analyzed obtain differences immune cell infiltration. gene functional enrichment analysis analyzed. PPI identified...
Due to unhealthy diet and living habits, the incidence of gout is on rise has become a common disease with high incidence. Danggui Niantong decoction (DGNTD), as classic formula composed 15 herbs, been widely used in clinical practice since ancient times prevent treat gout. However, pharmacological mechanism target DGNTD are not clear.The potential active compounds targets were obtained by traditional Chinese medicine systems pharmacology (TCMSP) database, differential genes patients...
Objective The alteration in the mechanical environment of necrotic area is primary cause collapse observed osteonecrosis femoral head (ONFH). This study aims to evaluate biomechanical implications China‐Japan Friendship Hospital (CJFH) classification system and hip flexion angles on ONFH using finite element analysis (FEA). goal provide valuable guidance for preservation treatments serve as a reference clinical diagnosis therapeutic interventions. Methods Hip tomography CT scan data from...
Steroid-induced osteonecrosis of the femoral head (SONFH) is pathological process caused by death active components femur due to high dose hormones, which has become a common public health problem. BuShenHuoXue capsule (BSHXC) been clinically proven be effective against SONFH, main pharmacological action BSHXC tonifying kidney and promoting blood circulation, but mechanism remains explored.We established rat SONFH model injecting Methylprednisolone (MPS) into right gluteus muscle 30 mg/kg/d,...
Fatty acid synthase (FAS) is highly expressed in human adipocytes and cancer cells considered as a dual therapeutic target for obesity treatment. Garcinone E natural xanthone exists the pericarp of Garcinia mangostana. In previous studies, xanthones were reported to be active inhibitors FAS. present study, detailed inhibitory mechanism garcinone on FAS was investigated. We found that inhibited activity concentration-dependent manner with half-inhibitory concentration value 3.3 μM. The...
Background: Osteoarthritis (OA) is a chronic joint disease characterized by cartilage destruction and periarticular osteophyte formation. One therapeutic option for this condition, the Wutou Decoction (WTD) Chinese medicine formula, satisfactory in its efficacy. Here, we used bioinformatic molecular docking techniques to investigate mechanism of action WTD treatment OA.Methods: The active compounds (and their target proteins) 5 herbs were obtained searching Traditional Medicine Systems...
To use Gene Expression Omnibus (GEO) database coupled with Connectivity Map (CMap) databases to screen potential therapeutic drugs for osteonecrosis of femoral head (ONFH) rapidly.Raw genetic data accession number GSE74089 that contained eight hip articular cartilage specimens from four ONFH patients and healthy controls were obtained the then integrated using R identify differentially expressed genes (DEGs). Subsequently, several small molecular compounds most strongly negatively correlated...
(Abstracted from Ultrasound Obstet Gynecol 2020;55:96–104) Early pregnancy loss is most commonly caused by embryonic numerical and structural chromosomal abnormalities, which explain more than 50% of miscarriages. In recent years, submicroscopic copy-number variations (CNVs) have also been identified in some early miscarriage specimens.
ENN Science and Technology Development Co., Ltd. (ENN) is committed to generating fusion energy in an environmentally friendly cost-effective manner, which requires abundant aneutronic fuel. Proton-boron ( p-$^{11}$B or p-B) considered ideal choice for this purpose. Recent studies have suggested that p-B fusion, although challenging, feasible based on new cross-section data, provided a hot ion mode high wall reflection can be achieved reduce electron radiation loss. The beta good confinement...
Objective Osteonecrosis of the femoral head (ONFH) is a common orthopedic disease with high disability rate. The clinical effect BuShenHuoXue decoction (BSHX) for ONFH satisfactory. We aimed to elucidate potential angiogenic mechanisms BSHX in rat osteonecrosis model and bone marrow mesenchymal stem cells (BMSCs). Methods With vivo experiments, we established steroid‐induced (SONFH) using Sprague–Dawley (SD) rats (8‐week‐old). were randomly divided into five group 12 each given corresponding...
Recent mounting evidence suggests that shortening of telomere length (TL) is associated with impaired bone health; yet, a genetic causal relationship between TL and osteonecrosis remains uncertain. This study aimed to investigate the potential using bidirectional two-sample Mendelian randomization (MR). Genome-wide association summary statistics for were sourced from IEU Open genome-wide project, while data obtained FinnGen Biobank database. A range MR methodologies—including inverse...
<title>Abstract</title> Several observational studies have suggested an association between rheumatoid arthritis (RA) and abnormalities of ventricular structure function, yet the causal relationship remains unclear. This study aimed to assess seropositive seronegative RA function via Mendelian randomization (MR). Genetic data were derived from a genome-wide (GWAS) conducted within FinnGen study, GWAS 16 biventricular functional structural cardiac magnetic resonance (CMR) measurements...