A5027693546- Cancer-related molecular mechanisms research
- Anesthesia and Pain Management
- Nausea and vomiting management
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Circular RNAs in diseases
- Spine and Intervertebral Disc Pathology
- Healthcare and Venom Research
- RNA modifications and cancer
- Intensive Care Unit Cognitive Disorders
- Pain Mechanisms and Treatments
- Pediatric Pain Management Techniques
- Histone Deacetylase Inhibitors Research
- Prenatal Screening and Diagnostics
- Herpesvirus Infections and Treatments
- COVID-19 and healthcare impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Botulinum Toxin and Related Neurological Disorders
- Pain Management and Treatment
- Artificial Intelligence in Healthcare and Education
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Nutrition and Health in Aging
- Tendon Structure and Treatment
- Health disparities and outcomes
West China Hospital of Sichuan University
2019-2025
Sichuan University
2011-2025
West China Medical Center of Sichuan University
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Tianjin Medical University
2024
Lifan (China)
2024
Tsinghua University
2022-2023
National Clinical Research
2023
Guangdong University of Technology
2022
Third Affiliated Hospital of Nanchang University
2018-2021
Embryonic numerical and structural chromosomal abnormalities are the most common cause of early pregnancy loss. However, role submicroscopic copy-number variations (CNVs) in loss is unclear, little known about critical regions candidate genes for miscarriage, because large size abnormalities. The aim this study was to identify potential miscarriage-associated CNVs as well miscarriage.Over a 5-year period, 5180 fresh miscarriage specimens were investigated using quantitative fluorescent...
Long non-coding RNA (lncRNA) SNHG5 has been found to play an important role in tumors. Nevertheless, the function and mechanism of lncRNA osteosarcoma (OS) remains unclear. The purpose this study was investigate whether can regulate occurrence development OS cells. We performed quantitative real time PCR detect expression 143B, MG63 (knockdown) U2OS, U2R (overexpression) cell lines were chosen for SNHG5. effect SNHG5, miR-212-3p, SGK3 cells explored by MTT assays, clony formation, flow...
Timely detection of modifiable risk factors for postoperative pulmonary complications (PPCs) could inform ventilation strategies that attenuate lung injury. We sought to develop, validate, and internally test machine learning models use intraoperative respiratory features predict PPCs.
Abstract Purpose Emergence agitation (EA) after (adeno)tonsillectomy (AT) surgery impairs recovery in children. Adequate analgesia plays a crucial role reducing EA incidence. This study investigated whether hydromorphone infusion (30 μg/kg) during anesthesia induction could reduce following AT for obstructive sleep apnea Patients and methods A total of 186 ASA I–III children aged 3–7 years undergoing were enrolled blinded randomized trial comparing to fentanyl (4 μg/kg). The primary outcome...
Abstract Background Pediatric patients undergoing surgery frequently experience significant anxiety, which can result in adverse effects such as prolonged sedation and behavioral changes associated with pharmacological interventions oral midazolam. Video games offer a nonpharmacological distraction method that shows promise alleviating procedural anxiety without effects. However, the effectiveness of video compared to midazolam managing perioperative remains uncertain. Objective This study...
Periodontitis is a multifactorial disease that can lead to the progressive destruction of dental support tissue. However, detailed mechanisms and specific biomarkers involved in periodontitis remain be further studied. Recently, long non-coding RNAs (lncRNAs) have been found play more important role than other types RNAs. In our study, we analysed expression lncRNAs by analysing GSE16134.We identified highly correlated genes GSE16134 with weighted gene co-expression network analysis (WGCNA)...
Background: Previous observational studies have suggested the involvement of 25-hydroxyvitamin D [25(OH)D] in chronic pain. However, whether 25(OH)D is a novel target for management, causality remains unclear. Methods: A two-sample Mendelian randomization (MR) study was conducted to identify causal association between and low back pain (LBP). The primary analysis revealing from serum level (n = 417,580) on LBP (21,140 cases 227,388 controls). replicated performing MR estimates circulating...
Abstract Background Surgery in geriatric patients often poses risk of major postoperative complications. Acute kidney injury (AKI) is a common complication following noncardiac surgery and associated with increased mortality. Early identification at high AKI could facilitate preventive measures improve patient prognosis. This study used machine learning methods to identify important features predict patients. Methods The data for this were obtained from prospective cohort. Patients aged ≥ 65...
Abstract Aim Abnormalities in sleep patterns are a common health problem for the older adults. The relationship between sarcopenia and duration people is controversial. This research to examine association sarcopenia. Methods We drew 21,095 adults from China Health Retirement Longitudinal Survey (CHARLS). Not only we explore sarcopenia, but also compare three subcomponents. Moreover, sensitivity analysis was conducted by gender residence area ascertain discrepancy, separately. Finally, using...
Modern Olympics have increasingly benefited from the advancement of materials science. From February 4 to March 13, 2022, whole world has witnessed spectacular Olympic Winter Games and Paralympic held in Beijing, during which nanotechnologies are extensively applied play indispensable roles many aspects. Although these appear a very small length scale, they provided tremendous support all athletes with pursuit "faster, higher, stronger". In this Article, we highlight several representative...
Loop closure detection is a key technology for long-term robot navigation in complex environments. In this paper, we present global descriptor, named Normal Distribution Descriptor (NDD), 3D point cloud loop detection. The descriptor encodes both the probability density score and entropy of as descriptor. We also propose fast rotation alignment process use correlation coefficient similarity between descriptors. Experimental results show that our approach outperforms state-of-the-art...
Abstract Background The association between anemia and depression has been demonstrated in previous studies, but it's still unclear whether depressive symptoms as a hazard factor for anemia. findings of large-scale cross-sectional longitudinal examination such an among the middle-aged elderly individuals China were presented our study. Methods data from Health Retirement Longitudinal Study 2011 2015 evaluated. 10,179 5,887 participants included study, respectively. According to World...
Background Major adverse cardiovascular events (MACEs) within 30 days following noncardiac surgery are prognostically relevant. Accurate prediction of risk and modifiable factors for postoperative MACEs is critical surgical planning patient outcomes. We aimed to develop validate an accurate easy-to-use machine learning model predicting in geriatric patients undergoing surgery. Materials Methods The cohort study was conducted at academic medical center between June 2019 February 2023. outcome...
WT161 is a recently discovered histone deacetylase 6 (HDAC6) inhibitor which shows anti-tumor effects on multiple myelomas and breast cancer. However, the role of in retinoblastoma remains unclear. The aim this study to explore its underlying mechanisms.The anti-proliferation cells was examined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay soft agar colony formation assay. Cell apoptosis analyzed flow cytometer. DDP synergistic effect evaluated by isobologram...
Aim: To develop an oxidative phosphorylation (OXPHOS)-related gene signature of lung adenocarcinoma (LUAD). Materials & methods: We split The Cancer Genome Atlas LUAD cohort into a training set and test set; we used the least absolute shrinkage selection operator Cox method to structure OXPHOS-related prognostic in verified GSE30219 dataset. Meanwhile, diagnostic model was constructed using logistic method. Results: consisted seven genes (LDHA, CFTR, HSPD1, SNHG3, MAP1LC3C, COX6B2, TWIST1)....