Abstract A growing body of studies has demonstrated that long non‐coding RNA (lncRNA) are regarded as the primary section ceRNA network. This is thought to be case owing its regulation protein‐coding gene expression by functioning miRNA sponges. However, functional roles and regulatory mechanisms lncRNA‐mediated in cervical squamous cell carcinoma (CESC), well their use for potential prediction CESC prognosis, remains unknown. The aberrant profiles mRNA, lncRNA, 306 cancer tissues three...

The blockade of programmed cell death protein 1 (PD-1) as monotherapy has been widely used in melanoma, but to identify melanoma patients with survival benefit from anti-PD-1 is still a big challenge. There an urgent need for prognostic signatures improving the prediction immunotherapy responses these patients. We analyzed transcriptomic data pre-treatment tumor biopsies and clinical profiles advanced receiving only (nivolumab or pembrolizumab) PRJNA356761 PRJEB23709 sets training validation...

Abstract The therapeutic potential of extracellular vesicles (EVs) in bone regeneration is noteworthy; however, their clinical application impeded by low yield and limited efficacy. This study investigated the effect low‐intensity pulsed ultrasound (LIPUS) on efficacy EVs derived from periodontal ligament stem cells (PDLSCs) preliminarily explored its mechanism. PDLSCs were cultured with osteogenic media stimulated or without LIPUS, then LIPUS‐stimulated (L‐EVs) isolated separately. We...

Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in oral and maxillofacial region, primarily affecting tongue, gingiva, cavity, buccal mucosa, floor of mouth. It exhibits high rates recurrence metastasis, contributing to a poor prognosis for patients. Identifying molecular markers associated with OSCC holds significant value advancing its diagnosis, treatment, prognosis. Exosome Component 3 (EXOSC3) protein-coding gene involved auto-degradation E3 ubiquitin ligase COP 1...

Background: Immune infiltration of head and neck cancer (HNC) highly correlated with the patient's prognosis. However, previous studies failed to explain diversity different cell types that make up function immune response system. The aim study was uncover differences in phenotypes tumor microenvironment (TME) between HNC adjacent tissues using CIBERSORT method explore their therapeutic implications. Method: In current work, we employed evaluate relative proportions profiling 11 paired...

Periodontitis is a multifactorial disease that can lead to the progressive destruction of dental support tissue. However, detailed mechanisms and specific biomarkers involved in periodontitis remain be further studied. Recently, long non-coding RNAs (lncRNAs) have been found play more important role than other types RNAs. In our study, we analysed expression lncRNAs by analysing GSE16134.We identified highly correlated genes GSE16134 with weighted gene co-expression network analysis (WGCNA)...

With the growing aging population and longer life expectancy, periodontitis tooth loss have become major health concerns. The gut microbiota, as a key regulator in bone homeostasis, has gathered immense interest. Baicalin, flavonoid compound extracted from Scutellaria baicalensis Georgi, shown antioxidant anti-inflammatory activities.

Mg–1Mn alloy, extruded at a low temperature in our published protocol, contributed to the intensified basal texture and extremely refined microstructure with spheroidal nanoscale precipitates dispersing throughout matrix along grain boundaries, consequently resulting excellent mechanical properties where alloy exhibited tensile yield strength of 204.3 MPa ductility 38.8% room temperature. Therefore, was recommended as one potential materials for structural applications. In present...

Abstract Dental fluorosis is a very prevalent endemic disease. Although oral microbiome has been reported to correlate with different diseases, there appears be an absence of research recognizing any relationship between the severity dental and microbiome. To this end, we investigated changes in microbial community structure identified bacterial species associated moderate severe fluorosis. Salivary samples 42 individuals, assigned into Healthy (N = 9), Mild 14) Moderate/Severe (M&S, N...

Abstract Head and neck cancer (HNC) remains one of the most malignant tumors with a significantly high mortality. DNA methylation exerts vital role in prognosis HNC. In this study, we try to screen abnormal differential genes (DMGs) pathways Head–Neck Squamous Cell Carcinoma via integral bioinformatics analysis. Data gene expression microarrays were obtained from Cancer Genome Atlas database. Aberrant DMGs identified by R Limma package. We conducted Cox regression analysis select prognostic...

Background/Aims: Kidney renal clear cell carcinoma (KIRC) is one of the most fatal malignancies due to late diagnosis and poor treatment. To improve its prognosis, a screening for molecular biomarkers KIRC urgently needed. Long non-coding RNAs (lncRNAs) play important roles in tumorigenesis prognosis cancers. However, it not whether lncRNAs can be used as predicting survival patients. Methods: In this study, our aim was identify lncRNAs/mRNAs signatures their prognostic values KIRC. The...

Previous studies have shown that alternative splicing (AS) plays a key role in carcinogenesis and prognosis of cancer. However, systematic profiles AS signatures head neck cancer (HNC) not yet been reported.In this study, data, RNA-Seq corresponding clinicopathological information 489 HNC patients were downloaded from The Cancer Genome Atlas. Univariate multivariate Cox regression analyses performed to screen for survival-associated events. Functional pathway enrichment analysis was also...

Periodontitis progression is accompanied by irreversible alveolar bone absorption and leads to tooth loss. Early diagnosis important for stability periodontal tissue preservation. However, there no recognized miRNA diagnostic signature with convincing sensitivity specificity periodontitis. In this study, we obtained array expression profiles of periodontitis from the Gene Expression Omnibus (GEO) database. After screening differentially expressed miRNAs, least absolute shrinkage selection...

Abstract Breast cancer (BC) is the most common leading cause of cancer-related death in women worldwide. Gene expression profiling analysis for human BCs has been studied previously. However, co-expression BC cell lines still devoid to date. The aim study was identify key pathways and hub genes that may serve as a biomarker uncover potential molecular mechanism using weighted correlation network analysis. We analyzed microarray data (GSE 48213) listed Expression Omnibus database. networks...

In this paper, the effect of aluminium on microstructure and mechanical properties as-cast magnesium–manganese alloy has been investigated by means X-ray diffraction, optical microscopy scanning electron microscopy. The results reveal that various Al–Mn intermetallic compounds form with an increase Al content. As a result, AM11 effectively refined due to formation 8 Mn 5 phase along grain boundary, while addition is explained as main reason refining AM91 its higher growth restriction factor...

Abstract Objectives Calcifying nanoparticles (CNPs), referred to as nanobacteria (NB), are recognized be associated with ectopic calcification. This study aims isolate and culture CNPs from the dental plaque of patients periodontal disease investigate their possible role in unravelling aetiology disease. Material Methods Supragingival subgingival plaques were sampled 30 periodontitis for isolation culture. Alkaline phosphatase (ALP) content changes tracked over time. Positive samples...

The whole chloroplast genome of Amorphophallus konjac is determined in this study. size was 161,647 bp length, containing a large single copy region 90k and small 20k bp, which were separated by pair 25,722 inverted repeat regions. complete contained 131 genes, including 86 coding-protein (79 PCG species), 8 rRNA (4 37 tRNA genes (30 species). Based on the phylogenetic analysis, genus Amorphophallus, represented A. might show close relationship with Pinellia Colocasia limited data for...