Abstract Coronavirus disease 2019 (COVID‐19) is a global pandemic that has caused severe health threats and fatalities in almost all communities. Studies have detected acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) saliva with viral load lasts for long period. However, researchers are yet to establish whether SARS‐CoV‐2 can directly enter the salivary glands. Therefore, this study aimed assess presence of angiotensin‐converting enzyme (ACE2)/transmembrane serine proteases (TMPRSS2)...

Abstract A growing body of studies has demonstrated that long non‐coding RNA (lncRNA) are regarded as the primary section ceRNA network. This is thought to be case owing its regulation protein‐coding gene expression by functioning miRNA sponges. However, functional roles and regulatory mechanisms lncRNA‐mediated in cervical squamous cell carcinoma (CESC), well their use for potential prediction CESC prognosis, remains unknown. The aberrant profiles mRNA, lncRNA, 306 cancer tissues three...

Several studies have shown a possible correlation between gut microbiota and COVID-19. However, the cause-and-effect relationship two has not been investigated. We conducted two-sample Mendelian randomization study (MR) using publicly available GWAS data. Inverse variance weighted (IVW) analysis was main MR technique supplemented with other sensitivity analyses. Forty-two bacterial genera were associated COVID-19 susceptibility, hospitalization, severity in IVW method. Among these...

Abstract Background The American Heart Association has developed a novel cardiovascular health indicator called Life’s Essential 8 (LE8). However, no one reported using LE8 to assess periodontitis. This study aimed investigate the association between and periodontitis in adults. Methods Data from National Health Nutrition Examination Survey (NHANES) 2009 2014 were used for this investigation. was independent variable, it is divided into three grades: high, moderate, low. Periodontitis...

Abstract Background Sedentary behavior (SB) may contribute to obesity and lower extremity fluid retention, which favor the development of obstructive sleep apnea (OSA). However, linking sedentary OSA is unclear. The purpose this study was determine if there an association between SB OSA. Methods Three typical questions in NHANES questionnaire(①The frequency feeling excessively sleepy per month. ②The gasping, snorting or stopping breathing week. ③The snoring week.) have been used for...

Abstract Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, and the 5‐year survival rate was only 7.7%. To improve screening biomarker for early diagnosis of pancreatic cancer is in urgent need. Long non‐coding RNA (lncRNA) expression profiles as potential prognostic biomarkers play critical roles development tumorigenesis metastasis cancer. However, lncRNA signatures predicting patient with PDAC remain unknown. In current study, we try to identify their values PDAC. LncRNAs...

Abstract There is growing evidence that alternative splicing (AS) plays an important role in cancer development. However, a comprehensive analysis of AS signatures kidney renal clear cell carcinoma (KIRC) lacking and urgently needed. It remains unclear whether acts as diagnostic biomarkers predicting the prognosis KIRC patients. In work, gene expression clinical data were obtained from The Cancer Genome Atlas (TCGA), profiles events downloaded SpliceSeq database. RNA sequence/AS information...

This study aimed to investigate the polymorphism of porcine-origin Ral guanine nucleotide dissociation stimulator (RalGDS) in LLC-PK1 cells using RT-PCR and sequencing. Our results revealed seven polymorphisms RalGDS gene, including insertions, deletions, frameshift mutations. These variations may significantly alter protein structure function RalGDS, potentially influencing its role GTPase-mediated signaling pathways. work provides foundational insights into genetic diversity porcine...

Background The principal objective of the present investigation is to undertake an in-depth exploration relationship that exists between newly introduced weight-adjusted waist index (WWI), employed as a surrogate way for corpulence, and obstructive sleep apnea (OSA). Methods Analysis using cross-sectional data from 11,545 NHANES participants across 2005–2008 2015–2020. Obesity via WWI (waist circumference over sqrt body weight). OSA 3 QnA items: monthly excessive sleepiness, weekly...

Background: Immune infiltration of head and neck cancer (HNC) highly correlated with the patient's prognosis. However, previous studies failed to explain diversity different cell types that make up function immune response system. The aim study was uncover differences in phenotypes tumor microenvironment (TME) between HNC adjacent tissues using CIBERSORT method explore their therapeutic implications. Method: In current work, we employed evaluate relative proportions profiling 11 paired...

Cadmium (Cd) is a pollutant with multiple adverse health effects: cancer, renal dysfunction, osteoporosis and fracture, cardiovascular disease. Several population-based studies found an association between Cd diabetes mellitus (DM), but this inconsistent other research. We conducted meta-analysis to examine relationship urinary/blood exposure DM risk. Pertinent were identified by searching PubMed Embase databases, combined odds ratio (OR) corresponding 95% confidence interval (CI) applied...

Abstract Purpose: Stomach adenocarcinoma (STAD) is one of the most common malignant tumors, and its occurrence prognosis are closely related to inflammation. The aim present study was identify gene signatures construct an immune-related (IRG) prognostic model in STAD using bioinformatics analysis. Methods: RNA sequencing data from healthy samples with STAD, IRGs, transcription factors were analyzed. hub IRGs identified univariate multivariate Cox regression analyses. Using we constructed IRG...

YTH domain-containing protein 2 (YTHDC2), a member of N6-methyladenosine (m6A) readers, has been reported to be closely associated with multiple cancer types. However, very little is known about the YTHDC2 gene and its involvement in prostate cancer. expression level was analyzed correlated clinical outcomes patients who underwent prostatectomy Guizhou Provincial People's Hospital. The also detected cell lines an immortalized epithelial line BPH-1 RWPE1 by quantitative real-time reverse...

Abstract Head and neck cancer (HNC) remains one of the most malignant tumors with a significantly high mortality. DNA methylation exerts vital role in prognosis HNC. In this study, we try to screen abnormal differential genes (DMGs) pathways Head–Neck Squamous Cell Carcinoma via integral bioinformatics analysis. Data gene expression microarrays were obtained from Cancer Genome Atlas database. Aberrant DMGs identified by R Limma package. We conducted Cox regression analysis select prognostic...

Background/Aims: Kidney renal clear cell carcinoma (KIRC) is one of the most fatal malignancies due to late diagnosis and poor treatment. To improve its prognosis, a screening for molecular biomarkers KIRC urgently needed. Long non-coding RNAs (lncRNAs) play important roles in tumorigenesis prognosis cancers. However, it not whether lncRNAs can be used as predicting survival patients. Methods: In this study, our aim was identify lncRNAs/mRNAs signatures their prognostic values KIRC. The...

The complete nucleotide sequence of the cDNA genome for garlic virus X (GVX), one major viruses infecting plants, was determined. GVX is a single-stranded positive-sense RNA consisting 8106 nucleotides excluding 3 ′-end poly(A) tail and contains six open reading frames (ORFs) which encode putative proteins 174 kDa (ORF1), 26 (ORF2), 12 (ORF3), 32 (ORF4), (ORF5) 15 (ORF6). viral show similarity to those carlaviruses potexviruses but highest homology shallot (ShVX). Even though most structural...

Previous studies have shown that alternative splicing (AS) plays a key role in carcinogenesis and prognosis of cancer. However, systematic profiles AS signatures head neck cancer (HNC) not yet been reported.In this study, data, RNA-Seq corresponding clinicopathological information 489 HNC patients were downloaded from The Cancer Genome Atlas. Univariate multivariate Cox regression analyses performed to screen for survival-associated events. Functional pathway enrichment analysis was also...

Increasing studies suggest that tumor immune infiltration is a relative factor of prognosis in ovarian cancer (OvCa). The present study explored the composition tumor-infiltrating cells (TIICs) OvCa using CIBERSORT algorithm and further assessed their values for therapeutic strategies by molecular subtypes.Publicly available databases including Cancer Genome Atlas (TCGA) GTEx were searched. Ovarian samples from TCGA, normal obtained dataset. proportions cell profiling evaluated algorithm....