A5101671090- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Endometrial and Cervical Cancer Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Sarcoma Diagnosis and Treatment
- Uterine Myomas and Treatments
- Oral microbiology and periodontitis research
- Lung Cancer Research Studies
- Pathogenesis and Treatment of Hiccups
- MicroRNA in disease regulation
- Nausea and vomiting management
- Circular RNAs in diseases
- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
- Pain Management and Opioid Use
- Genetic factors in colorectal cancer
- Endometriosis Research and Treatment
- Family Support in Illness
- Bone Metabolism and Diseases
- Pharmacological Effects and Toxicity Studies
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- dental development and anomalies
- Single-cell and spatial transcriptomics
Zunyi Medical University
2016-2024
Wuhan University
2023
Stomatology Hospital
2019
State Key Laboratory of Silkworm Genomic Biology
2018
Southwest University
2018
Bridge University
2016
The blockade of programmed cell death protein 1 (PD-1) as monotherapy has been widely used in melanoma, but to identify melanoma patients with survival benefit from anti-PD-1 is still a big challenge. There an urgent need for prognostic signatures improving the prediction immunotherapy responses these patients. We analyzed transcriptomic data pre-treatment tumor biopsies and clinical profiles advanced receiving only (nivolumab or pembrolizumab) PRJNA356761 PRJEB23709 sets training validation...
Objective: The stratification of neuroblastoma (NBL) prognosis remains difficult. RNA-based signatures might be able to predict prognosis, but independent cross-platform validation is still rare. Methods: RNA-Seq-based profiles from NBL patients were acquired and then analyzed. RNA-Seq prognostic index (RPI) the clinically adjusted RPI (RCPI) successively established in training cohort (TARGET-NBL) verified (GSE62564). Survival prediction was assessed using a time-dependent receiver...
Periodontitis is a multifactorial disease that can lead to the progressive destruction of dental support tissue. However, detailed mechanisms and specific biomarkers involved in periodontitis remain be further studied. Recently, long non-coding RNAs (lncRNAs) have been found play more important role than other types RNAs. In our study, we analysed expression lncRNAs by analysing GSE16134.We identified highly correlated genes GSE16134 with weighted gene co-expression network analysis (WGCNA)...
Introduction: Dysregulated genes play a critical role in the development and progression of cancer, suggesting their potential as novel independent biomarkers for cancer diagnosis prognosis. Prognostic model-based gene expression profiles are not widely utilized clinically. We investigated prognostic significance an profile-based signature outcome prediction patients with malignant pleural mesothelioma (MPM). Methods: The large cohort MPM were obtained analyzed by repurposing publicly...
Abstract Objective This study is to investigate the relationship between marital status and prognosis of patients with ovarian serous carcinoma. Results We performed data analysis from 19,276 identified SEER database National Cancer Center United States. 57.8% were married, 13.0% unmarried, 29.2% separated/ divorced/widowed (SDW). The median overall survival time ofthe unmarried group married are 48 months 52 respectively. Univariate Cox regression showed that cancer in resulted a hazard...
Background Development of severe immune-related adverse events (irAEs) is a major predicament to stop treatment with immune checkpoint inhibitors, even though tumor progression suppressed. However, no effective early phase biomarker has been established predict irAE until now. Method This study retrospectively used the data four international, multi-center clinical trials investigate application blood test biomarkers irAEs in atezolizumab-treated advanced non-small cell lung cancer (NSCLC)...
Melanoma is the most aggressive skin malignancy with high morbidity. Anti-programmed cell death protein 1 (PD-1) monotherapy has been applied in metastatic melanoma. However, still of patients do not respond to anti-PD-1 and availability present approved biomarkers therefore limited. Here we combined transcriptomic clinical data 163 advanced melanoma receiving from NIH Genome Sequencing Project (phs000452, 122 patients) as training internal validation cohort, Institute Australia cohort...
Periodontitis progression is accompanied by irreversible alveolar bone absorption and leads to tooth loss. Early diagnosis important for stability periodontal tissue preservation. However, there no recognized miRNA diagnostic signature with convincing sensitivity specificity periodontitis. In this study, we obtained array expression profiles of periodontitis from the Gene Expression Omnibus (GEO) database. After screening differentially expressed miRNAs, least absolute shrinkage selection...
Abstract Baculovirus–host interactions are important models for studying the biological control of lepidopteran pests. Research on baculovirus–host has focussed baculovirus manipulation cellular signalling pathways, including extracellular signal‐regulated kinase (ERK) and phosphatidylinositol‐3‐kinases/protein B (PI3K/Akt) pathways. However, mechanism underlying ERK PI3K/Akt activation function in response to infection remains poorly understood. Here, we demonstrated that activated Bombyx...
Peri-implantitis is an irreversible infectious disease that occurs with high incidence. Exploring the immune responses of peri-implantitis key to developing targeted treatment strategies. However, there limited research on response peri-implantitis.This study performed a weighted gene co-expression network analysis identify related and conducted functional enrichment network. Thereafter, candidate hub genes were selected by constructing protein-protein interaction drawing upset plot. The...
Background: IGF-1 may be an important factor in bone remodeling, but its mechanism of action on osteoclasts during orthodontic tooth movement is complex and unclear. Methodology: The closed-coil spring was placed between the left maxillary first molar upper incisors with a force 50 g to establish model. Eighty SD rats were randomized receive phosphate buffer saline or 400 ng rhIGF-1 lateral buccal mucosa every two days. Tissue sections stained for tartrate-resistant acidic phosphatase...
Chemotherapy-induced peripheral neuropathy (CIPN) is among the most disabling and frustrating problems for cancer survivors. The neurotoxicity caused by cisplatin varies greatly patients, few predictors of appearance, duration symptoms, susceptibility, or severity are available. A deeper understanding mechanisms underlying individual differences in status, severity, sensitivity response to treatment therefore required. By analyzing GSE64174 gene expression profile constructing a weighted...
Endogenous retrovirus (ERV) elements are genomic footprints of ancestral retroviral infections within the human genome. Previous studies have demonstrated that dysregulated ERV transcription level is associated with immune cell infiltration in cancers, but association between expression and programmed death protein 1 (PD-1) blockade response currently unraveled for solid such as advanced clear renal carcinoma (ccRCC).ERV mRNA profiles were obtained from three clinical trials ccRCC where...
Importance Blood cell count test (BCT) is a robust method that provides direct quantification of various types immune cells to reveal the landscape predict atezolizumab treatment outcomes for clinicians decide next phase treatment. Objective This study aims define new BCTscore model benefits in non-small lung cancer (NSCLC) patients. Design, Setting, and Participants analyzed four international, multicenter clinical trials (OAK, BIRCH, POPLAR, FIR trials) conduct post-hoc analyses NSCLC...
<title>Abstract</title> <bold>Background:</bold>Uterine sarcoma (US) is an extremely rare and aggressive gynecologic malignancy with a poor overall survival (OS). The early screening diagnosis of uterine still challenging, while efficient prognostic biomarker currently lacking. In this study, we evaluated the expression β-catenin in different US subtypes relationship between clinicopathological characteristics by comparative analyses, then explored potential molecular...
Radiotherapy showed synergy with immunotherapy, yet the comparative effectiveness of combining immunotherapy (iRT) or chemotherapy (CRT) after platinum therapy failure in advanced non-small cell lung cancer (NSCLC) remains unexplored. We analyzed 163 patients (iRT: