Objective: The stratification of neuroblastoma (NBL) prognosis remains difficult. RNA-based signatures might be able to predict prognosis, but independent cross-platform validation is still rare. Methods: RNA-Seq-based profiles from NBL patients were acquired and then analyzed. RNA-Seq prognostic index (RPI) the clinically adjusted RPI (RCPI) successively established in training cohort (TARGET-NBL) verified (GSE62564). Survival prediction was assessed using a time-dependent receiver...

Elsinochrome pigments produced by many phytopathogenic Elsinoë spp. are nonhost-selective toxins which react with oxygen molecules after light activation to produce highly toxic reactive species. The structures and chemical properties of four derivatives well known. However, the biological roles elsinochromes in fungal pathogenesis poorly understood. Many isolates fawcettii causing citrus scab able under axenic conditions. In this article, we report cloning, expression, functional...

Background . Chinese herbal medicine Dingji Fumai Decoction (DFD) is widely clinically used for ventricular premature contraction (VPC). This real-word trial was designed to assess the safety and effectiveness of DFD VPC. Methods a double-blinded, randomized placebo-controlled trial. Patients with VPC were (1 : 1) treatment combined metoprolol (DFD arm) or placebo (MET arm). A primary end point composite clinical symptoms signs determined by traditionalChinese syndrome score number Holter...

Aims We aimed to comprehensively assess the safety and efficacy of mavacamten in hypertrophic cardiomyopathy (HCM) patients. Methods A systematic review meta-analysis was conducted, [changes postexercise left ventricular outflow tract (LVOT) gradient, ejection fraction (LVEF), peak oxygen consumption (pVO 2 ), Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ CSS), proportion patients exhibiting an improvement at least one New York Heart Association (NYHA) functional...

Dingji Fumai decoction (DFD) is used to treat ventricular arrhythmia, and it has provided a very good curative effect. However, its cellular electrophysiological mechanism unknown.Electrocardiogram was recorded, oxidative stress response ion-channel-related molecules were detected in rats with barium chloride- aconitine-induced arrhythmia. Moreover, whole-cell patch-clamp assay investigate the inhibitory effect of DFD on Nav1.5 Chinese hamster ovary cells.DFD prolonged occurrence time...

Elsinochromes are nonhost-selective, light-activated, polyketide-derived toxins produced by many phytopathogenic Elsinoë species. We recently showed that the polyketide synthase-encoding gene EfPKS1 is essential for elsinochrome biosynthesis in citrus scab fungus fawcettii. Sequence analysis beyond identified nine putative ORFs: four genes, designated RDT1, TSF1, PRF1 and ECT1, all encode polypeptides likely to have biosynthetic or efflux functions; five additional OXR1 EfHP1 EfHP4,...

Objectives: To test the factors that influence Chinese medicine outpatients' behavior patterns in purchasing Traditional Medicine (TCM) under National Health Insurance (NHI) system Taiwan. Methods: A structural questionnaire was developed and administered to randomly selected outpatients waiting for at pharmacies two academic hospitals offered services central total of 641 effective questionnaires were collected. SPSS 10.0 (Statistical Package Social Sciences, Inc., Chicago, IL) used run...

Atherosclerosis is a chronic immuno-inflammatory disease, however, the immune landscape and regulatory mechanisms have not been clear. We detected seven principal cell clusters with distinct phenotypic spatial characteristics using single-cell RNA-sequencing of aortic cells from patients acute coronary syndrome stable angina pectoris. Then we acquired 265 differentially expressed immune-related genes high scores were mainly found in T monocytes, which regulated atherosclerotic plaques. The...

Objectives: This study used a nationwide population-based dataset from the 1997–2003 National Health Insurance claims to explore prevalence, frequency, and relative risk of concurrent use systemic corticosteroids with licorice-containing Traditional Chinese Medicine (TCM) preparations that might possibly result in drug–herb interactions. Design: was based on complete datasets Western medicine TCM outpatient reimbursement 1997 2003 contained Research Database Taiwan. According date duration...

Elsinoé fawcettii causes scab disease in citrus worldwide. Many E. isolates produce the phytotoxin elsinochrome that is required for fungal pathogenesis. We previously observed most of field-collected from Florida produced on rough lemon (Citrus jambhiri), grapefruit paradisi), and sour orange aurantium), belonging to “Florida Broad Host Range” pathotype. A small portion failed induce orange, resembling Narrow Of 71 examined, 5 did not belong either In this study, we further investigated...

Abstract Background: All cancers increase developing venous thromboembolism risk, and VTE is the second-leading cause of death among cancer patients. The anticoagulant drugs are considered to be optimal treatment for patients with cancer-associated VTE. However, there still controversy whether rivaroxaban, a new oral anticoagulant, can lead better outcomes globally. Methods: We will search PubMed, Web Science, Cochrane Central Register Controlled Trials China National Knowledge...

Resumo Fundamento O infarto do miocárdio com elevação segmento ST (IAMCSST) é uma das principais causas de doenças cardiovasculares fatais, que têm sido a principal causa mortalidade em todo o mundo. diagnóstico na fase inicial beneficiaria intervenção clínica e prognóstico, mas ainda falta exploração dos biomarcadores IAMCSST. Objetivos Neste estudo, conduzimos análise bioinformática para identificar potenciais cruciais no progresso Métodos Obtivemos GSE59867 pacientes IAMCSST doença arterial [...]

Objective: To evaluate the efficacy and safety of Mahuang Fuzi Xixin Decoction on sick sinus syndrome provide evidence for clinical practice. Methods: Randomized controlled trials all languages were collected by computer search manual retrieval. The retrieval time was from January2000 to January 2017. According inclusion exclusion criteria, 2 reviewers independently selected extracted data, then evaluated quality, cross-checked information quality menthodology. Through discussion or third...