A5101457874- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Biochemical effects in animals
- Natural Antidiabetic Agents Studies
- Phytoestrogen effects and research
- Viral Infections and Outbreaks Research
- Advanced biosensing and bioanalysis techniques
- Virology and Viral Diseases
- Fibroblast Growth Factor Research
- Viral gastroenteritis research and epidemiology
- Neuropeptides and Animal Physiology
- SARS-CoV-2 and COVID-19 Research
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Endometriosis Research and Treatment
- Advanced Glycation End Products research
- Alcohol Consumption and Health Effects
- Cancer Genomics and Diagnostics
- Advances in Oncology and Radiotherapy
- MicroRNA in disease regulation
- RNA modifications and cancer
- Metastasis and carcinoma case studies
- Cancer Risks and Factors
- Ophthalmology and Visual Impairment Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
Children's Hospital of Fudan University
2021-2025
Huazhong University of Science and Technology
2025
Tianjin Medical University
2025
Tianjin Medical University Eye Hospital
2025
Zunyi Medical University
2023-2024
Harbin Medical University
2024
Academy of Medical Sciences
2024
Nanjing Forestry University
2018-2022
Wake Forest University
2020
Atrium Health Wake Forest Baptist
2018
To investigate the progression of urodynamic changes, as well histological and biochemical outcomes over a prolonged period partial bladder outlet obstruction (pBOO) in an animal model with physiologically relevant pBOO.Healthy, adult, female Fischer rats underwent surgical creation pBOO for either 2, 4, 8, or 13 weeks were compared sham-operated rats. Urodynamic measurements used to compare volumes pressure. Tissue was grossly analysed light microscopy weights thicknesses compared. Reverse...
Regular lutein intake can improve metabolic health in adults with central obesity by increasing plasma concentrations, reducing oxidative stress, lowering TC, LDL-C, and ApoB levels, downregulating AGEs.
ABSTRACT The recently emerged severe acute respiratory syndrome coronavirus (SARS-CoV) contains four structural genes, two replicase-transcriptase open reading frames, and more than five potential genes of unknown function. Despite this relative simplicity, the molecular regulation SARS-CoV replication assembly is not understood. Here, we report that viral encoding membrane (M) nucleocapsid (N) proteins, are necessary sufficient for formation virus-like particles. Expression vectors these...
Quantitative assessment of corneal epithelial thickness (CET) has attracted a great attention for its wide application in refractive surgeries. The nerves are crucial homeostasis, and nerve injury due to surgery may affect the epithelia; however, few clinical studies have investigated this relationship. Our study aimed observe changes sub-basal plexus (SNP) profile after small incision lenticule extraction (SMILE) low-to-moderate myopia [spherical refraction -6.0 0 diopters (D)], investigate...
Jaranol, a bioactive compound derived from various traditional medicinal herbs, has demonstrated significant anti-inflammatory properties. This study investigates its effects and possible mechanisms underlying role in mast cells, as well ovalbumin (OVA)-induced allergic rhinitis (AR) mice model. Forty were randomly divided into blank, AR, dexamethasone (positive control), Jaranol groups (10 mg/ml), with 10 each group. was found to inhibit nasal mucosal inflammation reduce cell numbers AR...
Chronic pain occurs when normally protective acute becomes pathologically persistent. We examined here whether an isoform of protein kinase C (PKC), PKMζ, that underlies long-term memory storage in various brain regions, also sustains nociceptive plasticity spinal cord dorsal horn (SCDH) mediating persistent pain.
ABSTRACT The Ebola virus nucleoprotein (NP) is an essential component of the nucleocapsid, required for filovirus particle formation and replication. Together with virion protein 35 (VP35) VP24, this gene product gives rise to filamentous nucleocapsid within transfected cells. NP migrates aberrantly, apparent molecular mass 115 kDa, although it predicted encode ∼85-kDa protein. In report, we show that two domains determine aberrant migration region mediates its incorporation into virions....
Background Uterine sarcoma (US) is a highly malignant cancer with poor prognosis and high mortality in women. In this study, we evaluated the expression of human fibroblast growth factor 23 (FGF23) different US subtypes relationship between survival clinicopathological characteristics. Methods We conducted comparative analysis FGF23 gene pathological types US. Utilizing cohort from The Cancer Genome Atlas 57 patients, 50-patient microarray dataset (GSE119043) Gene Expression Omnibus Suining...
Detection of metastatic activity before the onset actual metastasis can be a promising method to combat metastasis, foremost cause death in cancer. Therefore, this work, we have developed an assay for detection tumor cells primary tumor, by using protein cell signaling as biomarker. In assay, peptide-based probe targeting marker and sensitive nanoparticle doped graphene nanolabel are combined enable cells. Consequently, specifically detected discriminated from By applying clinical samples...
Objective This study aimed to explore the potential molecular mechanism of allergic rhinitis (AR) and identify gene signatures by analyzing microarray data using bioinformatics methods. Methods The dataset GSE19187 was used screen differentially expressed genes (DEGs) between samples from patients with AR healthy controls. Gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses were applied for DEGs. Subsequently, a protein–protein interaction (PPI) network constructed...
Abstract There is accumulating evidence that continuous activation of the sympathetic nervous system due to psychosocial stress increases resistance therapy and accelerates tumor growth via β2-adrenoreceptor signaling (ADRB2). However, effector mechanisms appear be specific type. Here we show ADRB2 by epinephrine, increased in response immobilization stress, delays loss MCL1 apoptosis regulator (MCL1) protein expression induced cytotoxic drugs prostate cancer cells; thus, xenografts...
Abstract Objective To construct a pathway analysis model of breast cancer screening population in this region based on Anderson theory, and explore the influencing factors pathways results region, order to provide reference for refining strategies programs. Methods Firstly, distribution each variable detection related diseases was described by single factor analysis, then female 2021-2023 constructed according screening, so as clarify influence path coefficient factor. Results A total 1792...
<title>Abstract</title> Objective To compare the screening results of urban cancer early diagnosis and treatment project in Liangzhou District Wuwei City 2023 2022, analyze characteristics population changes, provide optimization suggestions for future development project. Methods The 2022–2023 data were extracted from system matched with telephone follow-up population, two-year compared by gender age. Chi-square test was used comparison between groups. Results From 2022 to 2023, a total...
Abstract Objective: The screening situation of rural upper gastrointestinal cancer was reported in this area, and the influencing factors paths were explored, so as to provide scientific basis for prevention treatment cancer. Methods: In Liangzhou district Wuwei City, 10 towns with high incidence selected by cluster sampling carry out screening. A hypothesis model factor pathway analysis patients City constructed using Anderson framework. According results screening, a path digestive tract...
<title>Abstract</title> <bold>Background:</bold>Uterine sarcoma (US) is an extremely rare and aggressive gynecologic malignancy with a poor overall survival (OS). The early screening diagnosis of uterine still challenging, while efficient prognostic biomarker currently lacking. In this study, we evaluated the expression β-catenin in different US subtypes relationship between clinicopathological characteristics by comparative analyses, then explored potential molecular...
Objectives: Uterine carcinosarcoma (UCS), often presenting at the advanced stage, is a rare, aggressive form of uterine cancer. We conduct prospective cohort study by systematically whole transcriptome sequencing data to gain further insights into transcriptomic landscape and molecular mechanism UCS. Methods: RNAs were extracted from tissue samples five UCS patients three corresponding non-tumorous tissues adjacent, followed Illumina technology for high-throughput sequencing. A functional...