A5100737047- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Biochemical effects in animals
- Natural Antidiabetic Agents Studies
- SARS-CoV-2 and COVID-19 Research
- Phytoestrogen effects and research
- COVID-19 Clinical Research Studies
- Lung Cancer Research Studies
- Tuberculosis Research and Epidemiology
- COVID-19 and Mental Health
- Growth Hormone and Insulin-like Growth Factors
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Advanced Glycation End Products research
- Mycobacterium research and diagnosis
- Caveolin-1 and cellular processes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Complement system in diseases
- Genetic and Kidney Cyst Diseases
- Metal-Catalyzed Oxygenation Mechanisms
- Advanced Proteomics Techniques and Applications
- PI3K/AKT/mTOR signaling in cancer
- Plant-based Medicinal Research
- HER2/EGFR in Cancer Research
Huazhong University of Science and Technology
2023-2025
Qingdao Municipal Hospital
2024
Qingdao University
2024
West China Hospital of Sichuan University
2015-2023
First Affiliated Hospital Zhejiang University
2023
Sichuan University
2015-2023
Wuhan Institute of Virology
2021
Chinese Academy of Sciences
2021
Zhuzhou Central Hospital
2020
Central South University
2020
Although it has been well recognized that the virus SARS-CoV-2, causative agent of COVID-19, can be acquired by exposure to fomites, surprisingly, contamination patients’ surroundings SARS-CoV-2 is largely unknown, as there have few studies. We performed an environmental sampling study for 13 laboratory-confirmed COVID-19 patients and found extensive surroundings. In particular, we asymptomatic contaminated their therefore imposed risks other people. Environment cleaning should emphasized in...
Regular lutein intake can improve metabolic health in adults with central obesity by increasing plasma concentrations, reducing oxidative stress, lowering TC, LDL-C, and ApoB levels, downregulating AGEs.
The underlying mechanisms for acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) in about 30%-40% of non-small cell lung cancer (NSCLC) patients remain elusive. Recent studies have suggested that activation epithelial-mesenchymal transition (EMT) and type 1 insulin-like receptor (IGF1R) is associated with EGFR-TKIs NSCLC. Our study aims further explore the mechanism EMT IGF1R NSCLC lines mutant (PC-9) or wild-type EGFR (H460). Compared parental...
Abstract Severe acute respiratory syndrome coronavirus 2 is responsible for the disease 2019 (COVID‐19) epidemic, which has severely affected global public health security. However, diagnosis and treatment of need further exploration. Therefore, this retrospective analysis was conducted on multiple indicators peripheral blood in patients with COVID‐19 to determine role leukocytes, lymphocytes, eosinophils prognostic evaluation COVID‐19. Baseline information clinical records 40 were...
We conducted a multicenter, partially randomized, platform trial to assess the effectiveness of booster dose an aerosolized or intramuscular adenovirus type 5 vectored COVID-19 vaccine (Ad5-nCoV) in Chinese adults (NCT05855408). Between May 23, 2023, and August 28, 4089 eligible participants were equally randomized receive either Ad5-nCoV via oral inhalation at 0.1 mL (IH Ad5-nCoV, n = 2039) injection 0.5 (IM 2050). Additionally, 2008 who declined but consented participate surveillance...
To investigate the distribution of epidermal growth factor receptor (EGFR) mutations, and explore any relationships with clinical characteristics in non-small-cell lung carcinoma (NSCLC) patients.EGFR mutations were assessed by ADx-ARMS 261 NSCLC patients from West China Hospital Sichuan University. Relationships between EGFR mutation analyzed SPSS.The rate was 48.7% (127/261), 19-del L858R occurred predominantly, accounting for 33.1% 40.9%, respectively, mutated cases. Moreover, 10.2% found...
Clinically diagnosed pulmonary tuberculosis (PTB) patients lack microbiological evidence of Mycobacterium , and misdiagnosis or delayed diagnosis often occurs as a consequence. We investigated the potential long noncoding RNAs (lncRNAs) corresponding predictive models to diagnose these patients. enrolled 1,764 subjects, including clinically PTB patients, microbiologically confirmed cases, non-TB disease controls, healthy in three cohorts (screening, selection, validation).
Background: Golgi phosphoprotein 3 (GOLPH3) is a metastasis-associated gene, however its role in cell proliferation of prostate cancer (PCa) has not yet been elucidated.Methods: The level expression GOLPH3 and other genes was examined by quantitative real-time PCR (QPCR) western blot analysis.Furthermore, we performed comprehensive analysis the PCa using tissue microarray (TMA) correlated our findings with pathological parameters PCa.RNA interference (RNAi) used to silence PC-3 cells measure...
Background We compared the therapeutic effect of EGFR‐tyrosine kinase inhibitors (TKIs) on 19Del and L858R mutations in advanced lung adenocarcinoma cellular immune function explored factors influencing curative prognosis. Methods Clinical efficacy selected 71 patients with adenocarcinoma, including 52 19 wild type treated EGFR‐TKIs was retrospectively analyzed. The response rate (RR), disease control (DCR), progression‐free survival (PFS), overall (OS), were Results RR, DCR, PFS, OS group...
Background: Sufficient supply of deoxyribonucleoside triphosphates (dNTPs) is required for the uncontrolled replication cancers. The current study aimed to investigate biological and clinical role ribonucleotide reductase subunit M2 (RRM2), a key enzyme regulating dNTP pool, in clear-cell renal cell carcinoma (ccRCC). Methods: expression RRM2 on disease progression patient outcome was assessed ccRCC. Then, effect inhibition (RCC) growth using siRNA or Triapine, an RRM2-specific inhibitor,...
Esophageal adenocarcinoma (EAC) is a molecularly heterogeneous disease that rising rapidly in incidence and has poor prognosis. We developed heterobivalent peptide to target detection of early Barrett's neoplasia by combining monomer heptapeptides specific for either EGFR or ErbB2 heterodimer configuration. The structure triethylene glycol linker was optimized maximize binding interactions the surface receptors on cells. Cy5.5-labeled QRH*-KSP*-E3-Cy5.5 demonstrated each showed 3-fold...
Purpose Recent clinical trials showed that the sequential combination of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and chemotherapy could prolong PFS and/or OS advanced non-small cell lung cancer (NSCLC) patients with EGFR mutation. The aim present study was to assess optimal sequence explore its possible mechanism. Methods PC-9 cells A549 cells, adenocarcinoma mutant wide-type respectively, were treated docetaxel/gefitinib alone or in different schedules. K-ras...
While a substantial amount of data on gene mutations related to acute myeloid leukemia (AML) prognosis from western and other populations have been reported, these studies largely describe one or two genes. Additionally, in southwest China, only insufficient exist regarding FLT3-ITD, FLT3-TKD, NPM1, C-KIT, DNMT3A, CEBPA widely used clinical settings. Therefore, comprehensive study about importance the AML China is necessary. In cohort 255 patients with de novo AML, we retrospectively...
Berberine, an active compound extracted from the Chinese herb, was reported to have antibacterial effect and anti-inflammatory promote osteogenic differentiation of human dental pulp stem cells. However, underlying therapeutic mechanism berberine in pulpitis is still unknown. Here, bioinformatics analysis performed investigate potential against pulpitis. First, we identified collective targets several databases using a Venny online tool. The pattern interaction between targeted protein...
Introduction: There is still lack of specific biomarkers in predicting the radiosensitivity non-small cell lung cancer (NSCLC) patients clinic. Previous studies have shown that EGFR gene status may correlate with NSCLC. However, underlying mechanisms remain unknown. The aim this study was to further investigate correlation between mutation and NSCLC explore possible cellular mechanism. Methods: Eight lines different were irradiated by linear accelerator, compared colony formation assay...
OBJECTIVE: This study was to explore the effects of RNA interference mediated vascular endothelial growth factor (VEGF) gene silencing on biological behavior renal cell carcinoma (RCC), transplanted tumor and angiogenesis in nude mice. METHODS: The specific siRNA sequence targeting VEGF we re designed synthesized construct hVEGF-siRNA plasmid which transfected into RCC 786-O cells. Reverse transcriptase-polymerase chain reaction (RT-PCR) used for detection expression western blot adopted...
Abstract Background The primary objective of this research was to assess if a booster dose with COVID-19 vaccines containing ancestral strain could still provide significant protection against symptomatic SARS-CoV-2 infection in predominantly hybrid-immune population during the period omicron variant dominance. Methods We did multicenter, partially randomized, platform trial evaluate effectiveness an aerosolized or intramuscular adenovirus type 5 vectored vaccine (Ad5-nCoV) adults, after...
Abstract Integrated action modes of regulated cell death (RCD) in lung adenocarcinoma (LUAD) have not been comprehensively dissected. Here, we adopted 15 RCD modes, including 1350 related genes, and established signature scores. We found that LUAD patients with high scores had a significantly worse prognosis all four different cohorts (TCGA, KM‐plotter, GSE31210, GSE30219). Our nomogram based on the score clinical characteristics performed well both discovery validation sets. There was close...
Tuberculosis (TB) is one of the leading causes morbidity and mortality in Western China. Preclinical studies have suggested protective effect C-type lectin receptor family 4 member E (CLEC4E) from TB. Herein, we investigated association between CLEC4E gene variants TB susceptibility a western Chinese Han population.