A5031980913- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Higher Education and Teaching Methods
- Topic Modeling
- Education and Work Dynamics
- Plant Virus Research Studies
- Insect symbiosis and bacterial influences
- Advanced Graph Neural Networks
- Respiratory viral infections research
- Immune cells in cancer
- SARS-CoV-2 and COVID-19 Research
- Virology and Viral Diseases
- Natural Language Processing Techniques
- Acute Myeloid Leukemia Research
- Protein Structure and Dynamics
- Genomics and Phylogenetic Studies
- Amino Acid Enzymes and Metabolism
- Educational Reforms and Innovations
- Innovative Educational Techniques
- Malaria Research and Control
- Single-cell and spatial transcriptomics
- Dengue and Mosquito Control Research
- Engineering Education and Curriculum Development
- Viral Infections and Immunology Research
- Advanced Text Analysis Techniques
Dali University
2024
Innovation Team (China)
2024
Institute of Biophysics
2020-2023
Chinese Academy of Sciences
2020-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2023
Zhejiang Normal University
2017-2020
National Health and Family Planning Commission
2020
National Institute for Viral Disease Control and Prevention
2018-2019
Chinese Center For Disease Control and Prevention
2018-2019
State Key Laboratory of Infectious Disease Prevention and Control
2018
Japanese encephalitis virus (JEV) is a representative of the JEV serogroup in genus Flavivirus, family Flaviviridae. mosquito-borne that causes (JE), one most severe viral diseases world. divided into five genotypes (G1–G5), and each genotype has its own distribution pattern. However, different changed markedly recent years. G1 replaced G3 as dominant traditional epidemic areas Asia, while spread from Asia to Europe Africa caused domestic JE cases Africa. G2 G5, which were endemic Malaysia,...
This study explores the impact of anthropogenic land use changes on macroinvertebrate community structure in streams Cangshan Mountains. Through field collections macroinvertebrates, measurement water environments, and delineation riparian zone eight streams, we analyzed relationship between types, stream diversities. The results demonstrate urban type temperature are key environmental factors driving differences communities up-, mid-, downstream. disturbed had lower aquatic biodiversity...
Human coronaviruses (HCoVs) HCoV-NL63, HCoV-229E, HCoV-HKU1 and HCoV-OC43 have been circulated in the human population worldwide, they are associated with a broad range of respiratory diseases varying severity. However, there neither effective therapeutic drugs nor licensed vaccines available for treatment prevention infections by four HCoVs. In this study, we collected nasopharyngeal aspirates children hospitalized tract infection China during 2014-2018 conducted next-generation sequencing....
Acute myeloid leukemia (AML) is a heterogeneous disease, and there are critical interests in detecting multiple biomarkers as single biomarker detection cannot reflect the exact phase of disease. Exosomes derived from different types AML cells contain respective combinations cluster differentiation (CD) markers that may be used to guide molecular typing clinic. Here, aiming build more precise AML, we demonstrate multiplex immuno-PCR (mI-PCR) assay for simultaneous surface CDs on exosomes via...
Recently, attempting to model texts as graph structure and introducing neural networks deal with it has become a trend in many NLP research areas. In this paper, we investigate whether the is necessary for textual multi-hop reasoning. Our analysis centered on HotpotQA. We construct strong baseline establish that, proper use of pre-trained models, may not be point out that both adjacency matrix are task-related prior knowledge, graph-attention can considered special case self-attention....
Human parainfluenza viruses (HPIV1–4) cause acute respiratory tract infections, thereby impacting human health worldwide. However, there are no current effective antivirals or licensed vaccines for infection prevention. Moreover, sequence information (HPIVs) circulating in China is inadequate. Therefore, to shed light on viral genetic diversity and evolution, we collected samples from patients infected with HPIV1–4 2012 2018 the viruses. We obtained 24 consensus sequences, comprising 1...
Abstract The diversity of protein functions is impacted in significant part by the chemical properties twenty amino acids, which are used as building blocks for nearly all proteins. ability to incorporate unnatural acids (UAA) into proteins a site specific manner can vastly expand repertoire and also allows detailed analysis function. In recent years UAAs have been incorporated site-specific number organisms. cases, amber codon sense an orthogonal tRNA/aminoacyl-tRNA synthetase (RS) pair...
Respiratory virus infections are one of the major causes acute respiratory disease or exacerbation chronic obstructive pulmonary (COPD). However, next-generation sequencing has not been used for routine viral detection in clinical samples owing to its sophisticated technology. Here, several pharyngeal with COPD were collected enrich particles using an optimized method (M3), which involved M1 centrifugation, filtration, and concentration, M2 (magnetic beads) combined mixed nuclease digestion,...
Kadipiro virus (KDV) belongs to the Reoviridae family, which consists of segmented, non-enveloped, double-stranded RNA viruses. It has previously been isolated from Culex, Anopheles, Armigeres and Aedes mosquitoes in Indonesia China. Here, we describe isolation characterization SDKL1625 Anopheles sinensis Shandong province, In this study, albopictus C6/36 cell culture complete genome sequencing was made by next generation sequencing. We characterized a 2016 Nucleotide amino acid homology...
We consider the importance of different utterances in context for selecting response usually depends on current query. In this paper, we propose model TripleNet to fully task with triple <context, query, response> instead previous works. The heart is a novel attention mechanism named relationships within at four levels. new updates representation each element based other two concurrently and symmetrically. match <C, Q, R> centered from char level prediction. Experimental results large-scale...
BACKGROUND: DNA methylation balance is an important regulatory mechanism for mammalian and plant development. The fruit ripening anthocyanin accumulation of Vaccinium corymbosum are complex developmental processes that involve numerous physiological, biochemical, structural alterations. OBJECTIVE: This study aimed to investigate the correlation balance, demethylation-related gene expression models during blueberry ripening. METHODS: contents V. ‘O’Neal’ development were evaluated....
Based on clinical samples collected in China, we detected and reported 22 types for the first time as well three Asia, their genetic characteristics diversity. We identified a novel type of Rhinovirus (RV), A110, highlighting its unique features. annotated genomic structure serotype all existing RV sequences database, four were diversity reported. Combined with sequence annotation, constructed complete VP1 data set conducted large-scale evolutionary dynamics analysis RV. high-quality set,...
Retrieving information from correlative paragraphs or documents to answer open-domain multi-hop questions is very challenging. To deal with this challenge, most of the existing works consider as nodes in a graph and propose graph-based methods retrieve them. However, paper, we point out intrinsic defect such methods. Instead, new architecture that models sequential data considers retrieval kind sequence labeling task. Specifically, design rewritable external memory model dependency among...
Acute myeloid leukaemia (AML) is characterised by the malignant accumulation of progenitors with a high recurrence rate after chemotherapy. Blasts (leukaemia cells) exhibit complete differentiation hierarchy hiding wide range temporal information from initial to mature clones, including genesis, phenotypic transformation, and cell fate decisions, which might contribute relapse in AML patients.Based on landscape surface antigens generated mass cytometry (CyTOF), we combined manifold analysis...