A5101918146- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Cytokine Signaling Pathways and Interactions
- Maternal and Perinatal Health Interventions
- Bacterial Infections and Vaccines
- Lung Cancer Treatments and Mutations
- TGF-β signaling in diseases
- Tuberculosis Research and Epidemiology
- Global Public Health Policies and Epidemiology
- Prostate Cancer Treatment and Research
- Pregnancy-related medical research
- Traditional Chinese Medicine Analysis
- Climate Change and Health Impacts
- Electroconvulsive Therapy Studies
- MicroRNA in disease regulation
- Global Maternal and Child Health
- Circular RNAs in diseases
- Treatment of Major Depression
- Global Health Care Issues
- Maternal and fetal healthcare
- Cholinesterase and Neurodegenerative Diseases
- Kruppel-like factors research
- Lung Cancer Research Studies
- Obesity, Physical Activity, Diet
Huizhou Central People's Hospital
2022-2025
Harbin Medical University
2023-2025
Daqing City People's Hospital
2023-2025
Jiaxing University
2025
Zhejiang Sci-Tech University
2025
Dongyang People's Hospital
2025
Wenzhou Medical University
2025
Xi'an Jiaotong University
2022-2024
Fourth Hospital of Hebei Medical University
2023-2024
Hebei Medical University
2023-2024
Laquinimod (LAQ) is a new oral immunomodulatory compound that reduces relapse rate, brain atrophy and disability progression in multiple sclerosis (MS). LAQ has well-documented effects on inflammation the periphery, but little known about its direct activity within central nervous system (CNS). To elucidate impact of CNS-intrinsic inflammation, we investigated cuprizone-induced demyelination mice vivo primary CNS cells vitro. Demyelination, axonal damage glial pathology were evaluated...
Maternal separation in early life has a detrimental effect on the physiological and biochemical functions of brains offspring can lead to anxiety- depression-like behaviors later life. Resveratrol possesses variety pharmacological properties, including anti-inflammatory, anxiolytic, anti-depressive effects. In rodents, resveratrol attenuate induced by chronic unpredictable mild stress, estrogen deficiency, lipopolysaccharide. However, whether administration during adolescence counteract...
Nasopharyngeal carcinoma (NPC) is an uncommon and aggressive malignant head neck cancer, which highly prevalent in southern southwestern provinces China. The aim of this study was to examine the disease burden risk factors nasopharyngeal China from 1990 2019 predict incidence trends 2020 2049. All data were extracted Global Burden Disease (GBD) study. Joinpoint regression age-period-cohort (APC) models chosen analyze prevalence trends. temporal age distribution also analyzed descriptively....
There have been obstacles for internal migrants in China accessing local public health services some time. This study aimed to estimate the utilization of and its determinants among migrants. Data were from 2014 2015 nationally representative cross-sectional survey China. Multivariate logistic regressions used relationship between socioeconomic, migration, demographic characteristics utilization. Our results showed that more developed eastern regions less services. Those with higher...
Breast cancer is a widespread disease in women worldwide.We aimed to explore the global epidemiological trends of female breast (FBC) between 1990 and 2044.Disease burden, population, socio-demographic index (SDI) data were obtained from Global Health Data Exchange (GHDx) database. We analyzed temporal trends, age differences, risk factors, geographic patterns FBC burden globally explored association age-standardized incidence rate (ASIR) SDI. Bayesian age-period-cohort model was also...
The incidence of depression is increasing in adolescents, who are at a stage education and therefore more concerned about their cognitive changes. We tried to preserve the rapid relief depressive symptoms electroconvulsive therapy (ECT) while causing less impairment, thus designing hybrid-ECT (HECT), modified ECT therapy. Here, we report case study 14-year-old male student with major disorder (MDD) suffering from severe suicidality significant impairment social functioning achieved effective...
ABSTRACT The function of super‐enhancers (SEs) in pulmonary hypertension (PH), especially the proliferation artery smooth muscle cells (PASMCs), is currently unknown. We identified SEs‐targeted genes PASMCs with chromatin immunoprecipitation (ChIP)‐sequence by H3K27ac antibody and proved that CBP/p300‐interacting transactivator Glu/Asp‐rich C‐terminal domain, 2 (CITED2) an gene through bioinformatics prediction, ChIP‐PCR, dual‐luciferase reporter assays other experimental methods. also found...
ABSTRACT Low temperature plasma jet (LTPJ) treatment can promote skin wound healing, but the underlying molecular mechanisms remain poorly understood. In present study, we verified effect of LTPJ in accelerating healing and investigated its mechanism. With mouse model, two full‐thickness dermal wounds were created each ( n = 8). One underwent for 10 min, while other without served as a control. The percentage closure collagen content epidermis increased significantly, which indicated that...
The reality shock experienced by nursing students in clinical practice has attracted considerable attention. However, existing studies largely focus on quantitative analysis and overlook the depth of individual experiences. This study adopts a qualitative research method utilizes hermeneutic phenomenology to examine faced during practice, demonstrate its impact development professional behavior provide empirical evidence improve education. A was adopted involving 30 completing 32-week...
This study measured occupational status from the perspectives of socioeconomic status, employment relationship, and class level, aiming to examine effect on depression among middle-aged elderly people in China determine whether being a state functionary plays moderating role. Panel data Family Studies (n = 28 645) were used year fixed-effects model was adopted. The 2-way interaction terms "state × (the International Socioeconomic Index Occupational Status [ISEI], Standard Prestige Scale...
Rho-associated coiled-coil kinase (ROCK)2 targeting down-regulates autoimmune responses in animal models and patients, however the underlying molecular mechanism is still an enigma. We report that ROCK2 binds phosphorylated-STAT3 its activity controls formation of ROCK2/STAT3/JAK2 complex optimal STAT3 phosphorylation human CD4+ T cells during helper 17 (TH17)-skewing. Moreover, chromatin-immunoprecipitation sequencing (ChIP-seq) analysis revealed that, genome-wide, about 70% peaks...
Growth factors of the gp130 family promote oligodendrocyte differentiation, and viability, myelination, but their mechanisms action are incompletely understood. Here, we show that these effects coordinated, in part, by transcriptional activator Krüppel-like factor-6 (Klf6). Klf6 is rapidly induced progenitors (OLP) factors, promotes differentiation. Conversely, mice with lineage-selective inactivation, OLP undergo maturation arrest followed apoptosis, CNS myelination fails. Overlapping...
Background Aberrant expression of circular RNAs (circRNAs) contributes to the initiation and progression pulmonary hypertension (PH). Hypoxia‐inducible factor (HIF) is a well‐known modulator hypoxia‐induced PH. The role underlying mechanism circRNAs in regulation HIF remains elusive. Methods Results We profiled artery transcriptomes using RNA sequencing screened associated with hypoxia treatment. novel circRNA, circ_chr11_67292179–67294612 (circ‐myh8), was increased by time‐dependent manner....
Musculoskeletal disorders are one of the three major disabling diseases in world. However, current disease burden China is not well-known. This study aimed to explore and risk factors musculoskeletal from 1990 2019, predicting incidence trend 2020 2044. All data were extracted Global Burden Disease Study 2019 (GBD 2019). Joinpoint regression age–period–cohort (APC) models selected analyze epidemic trend, descriptive analyses time trends age distributions performed. The Bayesian APC model was...
In the embryonic CNS, development of myelin-forming oligodendrocytes is limited by bone morphogenetic proteins, which constitute one arm transforming growth factor-β (Tgfβ) family and signal canonically via Smads 1/5/8. Tgfβ ligands Activins comprise other 2/3, but their roles in oligodendrocyte are incompletely characterized. Here, we report that activin B (ActB) act concert mammalian spinal cord to promote generation myelination. mouse neural tube, newly specified progenitors (OLPs) first...
Clinical research data show that gefitinib greatly improves the progression-free survival of patients, so it is used in advanced non-small cell lung cancer patients with EGFR mutation. However, some sensitive mutations do not have good effects on initial treatment, and this mechanism rarely studied. METTL3, a part N6-adenosine-methyltransferase, has been reported to play an important role variety tumours. In study, we found METTL3 up-regulated gefitinib-resistant tissues compared...
Recent studies have implicated long non-coding RNA, AC079767.4, as a highly susceptible gene in tuberculosis. The aim of the study was to preliminarily explore possible association single nucleotide polymorphisms (SNPs) AC079767.4 with clinical phenotypes and TB susceptibility Western Chinese Han population. improved multiplex ligation detection reaction (iMLDR) method employed genotype 4 SNPs 554 tuberculosis patients 561 healthy individuals. In subgroup analysis, only C allele for...
Pancreatic cancer (PC) is the fourth most common cause of cancer‑related mortality worldwide and characterized by high invasiveness early metastasis. To identify novel diagnostic markers, present study aimed to understand mechanism underlying PC progression. The demonstrated that exosomes derived from highly metastatic Panc‑1 cell line were internalized a low line, resulting in increased migration latter. Proteomics analysis further revealed receptor tyrosine kinase Eph A2 (EphA2) was...