A5073561377- Pulmonary Hypertension Research and Treatments
- Angiogenesis and VEGF in Cancer
- Glutathione Transferases and Polymorphisms
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Nitric Oxide and Endothelin Effects
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Ultrasound and Hyperthermia Applications
- Mesenchymal stem cell research
- Pelvic floor disorders treatments
- Cardiac Ischemia and Reperfusion
- Eicosanoids and Hypertension Pharmacology
- Ginseng Biological Effects and Applications
- Genomics, phytochemicals, and oxidative stress
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Kruppel-like factors research
- Chemotherapy-induced cardiotoxicity and mitigation
- Neuropeptides and Animal Physiology
- Sirtuins and Resveratrol in Medicine
- Microbial Natural Products and Biosynthesis
- Phytochemical compounds biological activities
Shuguang Hospital
2025
Shanghai University of Traditional Chinese Medicine
2023-2025
Harbin Medical University
2014-2025
Shenzhen University
2024
China Geological Survey
2023
Nanchang University
2020-2022
Daqing City People's Hospital
2017-2022
Shenzhen Second People's Hospital
2022
First Affiliated Hospital of Jiangxi Medical College
2020
Shandong University of Traditional Chinese Medicine
2020
Background Anal fistula surgery often leads to postoperative pain, which can hinder recovery and negatively impact patients’ quality of life. This prospective, randomised, controlled trial (RCT) aims investigate the efficacy acupuncture in alleviating pain reducing usage analgesic medications following anal surgery. Methods single-centre, patient-blinded, assessor-blinded, placebo-controlled randomised will be conducted at a tertiary referral hospital. A total 66 patients with low simple 1:1...
Background: In the clinical setting, individuals with neurogenic bladder dysfunction commonly utilize indwelling urinary catheters for management. The comparative efficacy of catheter clamping versus continuous free drainage in this patient population is yet to be established. This meta-analysis aims explore and safety natural patients bladder, provide evidence support treatment nursing care these patients. Methods: Two researchers conducted a literature search Clinicaltrials et al....
ABSTRACT The function of super‐enhancers (SEs) in pulmonary hypertension (PH), especially the proliferation artery smooth muscle cells (PASMCs), is currently unknown. We identified SEs‐targeted genes PASMCs with chromatin immunoprecipitation (ChIP)‐sequence by H3K27ac antibody and proved that CBP/p300‐interacting transactivator Glu/Asp‐rich C‐terminal domain, 2 (CITED2) an gene through bioinformatics prediction, ChIP‐PCR, dual‐luciferase reporter assays other experimental methods. also found...
The polyphenol resveratrol (Rev) has been found to exhibit various beneficial effects including prevention of pulmonary arterial hypertension (PAH). present study was designed investigate the action and potential mechanism Rev on PAH, focusing role SIRT1 (Silent Information Regulator 1) in apoptosis artery smooth muscle cells (PASMCs).PAH rats were established by exposure hypoxia for 21 days. SRT1720 (a selective activator) used reverse PAH gavaging rats. PASMCs confronted with 24 h or 48...
Glutathione-S transferases (GSTs) comprise a series of critical enzymes involved in detoxification endogenous or xenobiotic compounds. Among several GSTs, Glutathione S-transferases mu (GSTM) has been implicated number cancer types. However, the prognostic value and potential functions GSTM family genes have not investigated lung adenocarcinoma (LUAD).We examined expression GSTM5 LUAD identified associations among expression, clinicopathological features, survival data from Cancer Genome...
Stromal cell–derived factor 1 (CXCL12) and its receptor CXC chemokine 4 (CXCR4) are known to modulate hypoxia-induced pulmonary hypertension (PH) vascular remodeling by mobilization recruitment of progenitor cells the vasculature. However, little is about CXCL12/CXCR4 regulating proliferation cell cycle progression arterial smooth muscle (PASMCs). To determine whether regulates PASMC cycle, immunohistochemistry, Western blot, bromodeoxyuridine incorporation analysis were preformed in this...
Qiangxin recipe (QXF) is a well-known Chinese herbal medicine commonly used in Asia for thousands of years to treat cardiovascular diseases, but its underlying mechanism remains unclear.This study aimed illustrate whether Recipe induce glucose metabolism and inhibit cardiomyocyte apoptosis by promoting the activation transcription factor Krüppel like 5 (KLF5).In vitro experiments, we constructed an H9C2 injury model using doxorubicin RNA-seq data analysis detect QXF. In vivo C57 BL/6 mice...
Gastrodin, one of the major components extracted from Chinese herb Gastrodia elata Bl., has been widely used as an anticonvulsant, sedative, analgesic and hypotensive. In our study, we aimed to investigate effects possible mechanisms gastrodin on vascular KATP channels. Tension experiments were rat mesenteric artery rings without endothelium. Patch clamp executed influences membrane current in smooth muscle cells. Gastrodin induced vasorelaxation a concentration dependent manner when...
Enhancing glucagon-like peptide 1 (GLP-1) signaling with a dipeptidyl peptidase IV (DPP-4) inhibitor might exert protective effects on Alzheimer's disease (AD). We found that intragastric administration of Gramcyclin A (10, 20 and 40 mg/kg), novel DPP-4 inhibitor, for 3 months significantly reversed cognitive decline in APP/PS1/tau triple transgenic mice dose-dependent manner. treatment markedly reduced Aβ plaques as well the insoluble soluble forms Aβ40 Aβ42 hippocampus mice. Treatment...
Targeting the PPARγ might be a potential therapeutic strategy for diabetes-associated cognitive decline (DACD). In this study, Gypenoside LXXV (GP-75), dammarane-type triterpene compound isolated from Gynostemma pentaphyllum, was found to novel agonist using dual-luciferase reporter assay system. However, whether GP-75 has protective effects against DACD remains unknown. Interestingly, intragastric administration of (40 mg/kg/day) 12 weeks significantly attenuated deficit in db/db mice....
Angiogenesis plays a critical role in the progression of cardiovascular disease, retinal ischemia, or tumorigenesis. The imbalance endothelial cell proliferation and apoptosis disturbs establishment vasculogenesis, which is affected by several arachidonic acid metabolites. 15-Hydroxyeicosatetraenoic (15-HETE) one However, underlying mechanisms angiogenesis induced 15-HETE human umbilical vascular cells (HUVECs) are still poorly understood. Since extracellular signal-regulated kinase (ERK)...
Introduction: Due to its highly aggressiveness and malignancy, glioblastoma (GBM) urgently requires a safe effective treatment strategy. Zeylenone, natural polyoxygenated cyclohexenes compound isolated from Uvaria grandiflora , has exhibited potential biological activities in various human diseases, including tumors. Methods: We designed synthesized series of (+)-Zeylenone analogues evaluated their anti-GBM roles through structural-activity analysis. Cell Counting Kit-8, TUNEL, transwell...
Abstract We have previously reported that Gypenoside LXXV (GP‐75), a novel natural PPARγ agonist isolated from Gynostemma pentaphyllum , ameliorated cognitive deficits in db/db mice. In this study, we further investigated the beneficial effects on impairment APP/PS1 mice and mouse model of diabetic AD (APP/PS1xdb/db mice). Interestingly, intragastric administration GP‐75 (40 mg/kg/day) for 3 months significantly attenuated APP/PS1xdb/db treatment markedly reduced levels glucose, HbA1c...
The present study aimed to investigate the mechanism underlying protective effect of 2-deoxy-D-glucose (2-DG) on cytotoxicity cyclosporin A (CsA) in vitro using NRK-52E cells. Staining with Hoechst 33342/propidium iodide prior flow cytometric analysis was performed assess rate cellular apoptosis and necrosis induced by CsA. expression levels lactate dehydrogenase (LDH), caspase 3, receptor-interacting protein kinase 3 (RIP3), reactive oxygen species (ROS), glutathione (GSH) malondialdehyde...