A5010278889- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Meningioma and schwannoma management
- Prostate Cancer Treatment and Research
- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Pituitary Gland Disorders and Treatments
- Head and Neck Surgical Oncology
- Radiomics and Machine Learning in Medical Imaging
- TGF-β signaling in diseases
- Radiopharmaceutical Chemistry and Applications
- Radiation Therapy and Dosimetry
- Tracheal and airway disorders
- Cancer-related gene regulation
- Global Cancer Incidence and Screening
- Polyomavirus and related diseases
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Genital Health and Disease
Penn State Milton S. Hershey Medical Center
2022-2025
Pennsylvania State University
2023
Weill Cornell Medicine
2018-2023
Presbyterian Hospital
2017-2023
Cornell University
2017-2023
Memorial Sloan Kettering Cancer Center
2019-2022
Cancer Institute (WIA)
2022
New York Hospital Queens
2018-2021
NewYork–Presbyterian Hospital
2018-2021
Hofstra University
2017-2019
In inflammatory CNS conditions such as multiple sclerosis (MS), current options to treat clinical relapse are limited, and more selective agents needed. Disruption of the blood-brain barrier (BBB) is an early feature lesion formation that correlates with exacerbation, leading edema, excitotoxicity, entry serum proteins cells. Here, we identify astrocytic expression VEGF-A a key driver BBB permeability in mice. Inactivation Vegfa reduced breakdown, decreased lymphocyte infiltration...
Stereotactic body radiotherapy is a hypofractionated, cost-effective treatment option for localized prostate cancer.To characterize US national trends and the clinical socioeconomic factors associated with use of stereotactic in cancer.This retrospective cohort study used data collected by National Cancer Database to assess among 106 926 men diagnosed as having cancer from 2010 2015 who underwent definitive this therapy. The initial analysis was performed between January February 2018, final...
Abstract Background Brain metastases (BM) affect clinical management and prognosis but limited resources exist to estimate BM risk in newly diagnosed cancer patients. Additionally, guidelines for brain MRI screening are limited. We aimed develop validate models predict of at diagnosis the most common types that spread brain. Methods Breast cancer, melanoma, kidney colorectal (CRC), small cell lung (SCLC), non-small (NSCLC) data were extracted from National Cancer Database evaluate variables...
Meningiomas express high levels of somatostatin receptor 2 (SSTR2). SSTR2-targeted PET imaging with [68Ga]-DOTATATE can aid distinguishing residual meningioma from reactive changes in the postoperative setting. We present initial dosimetric analyses, acute events, and local control data utilizing PET/MRI-assisted target delineation for prospectively-treated intermediate-risk meningiomas.Twenty-nine patients underwent DOTATATE PET/MRI evaluation 2019. Eight 9 meningiomas met RTOG 0539...
Abstract Background A prior study reported that over half of patients with HNSCC initiated PORT after 6 weeks from surgery during 2006–2014. In 2022, the CoC released a quality metric for to initiate within weeks. This provides an update on time in recent years. Methods The NCDB and TriNetX Research Network were queried identify who received 2015–2019 2015–2021, respectively. Treatment delay was defined as initiating beyond surgery. Results NCDB, delayed 62% patients. Predictors included age...
While contrast-enhanced MR imaging is the criterion standard in meningioma diagnosis and treatment response assessment, gallium
In the embryonic CNS, development of myelin-forming oligodendrocytes is limited by bone morphogenetic proteins, which constitute one arm transforming growth factor-β (Tgfβ) family and signal canonically via Smads 1/5/8. Tgfβ ligands Activins comprise other 2/3, but their roles in oligodendrocyte are incompletely characterized. Here, we report that activin B (ActB) act concert mammalian spinal cord to promote generation myelination. mouse neural tube, newly specified progenitors (OLPs) first...
OBJECTIVE Publications on adjuvant stereotactic radiosurgery (SRS) are largely limited to patients completing SRS within a specified time frame. The authors assessed real-world local recurrence (LR) for all brain metastasis (BM) referred and identified predictors of timing. METHODS retrospectively BM undergoing resection between 2012 2018. Patients were categorized by SRS, as follows: 1) ≤ 4 weeks, 2) > 4–8 3) 8 4) never completed. relationships timing LR, LR-free survival (LRFS),...
Abstract Background Clinical trials evaluating immune checkpoint inhibition (ICI) in recurrent high‐grade gliomas (rHGG) report 7%–20% 6‐month progression‐free survival (PFS), while re‐irradiation demonstrates 28%–39% PFS. Aims We evaluate outcomes of patients treated with ICI and concurrent utilizing stereotactic body radiotherapy/fractionated radiosurgery (SBRT) compared to monotherapy. Methods Results Patients ≥18‐years‐old rHGG (WHO grade III IV) receiving + SBRT or monotherapy between...
Purpose/objective(s) In early-stage, node negative oral tongue cancer, there is limited data supporting tumor depth of invasion (DOI) as an indication for post-operative radiotherapy (PORT) to the primary site. The aim this study examine effect DOI and PORT on overall survival (OS). Materials methods National Cancer Database (NCDB) was used query patients with AJCC stage I II cancer (2006-2013). Patients were stratified by receipt PORT, elective neck dissection (ND), (≤4 mm or >4 mm)....
Abstract Purpose To investigate the impact of rectal spacing on inter‐fractional and bladder dose need for adaptive planning in prostate cancer patients undergoing SBRT with a 0.35 T MRI‐Linac. Materials Methods We evaluated compared plans from without spacer who underwent treatment Each group consisted 10 randomly selected that received to total 36.25 Gy five fractions. Dosimetric differences planned delivered number fractions violating OAR constraints were quantified. also assessed whether...
Stereotactic radiosurgery (SRS) is a minimally invasive, focal treatment option for brain metastases. Multiple studies support its use in various settings as an effective, comparable alternative to surgery and whole-brain radiation therapy (WBRT). Here, we present excellent outcomes 90-year-old patient who underwent SRS after initially presenting at age 84 with multiple metastases of unknown primary, well undergoing site tumor recurrence that was treated surgical resection intraoperative...