A5019249199- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Alzheimer's disease research and treatments
- Adrenal and Paraganglionic Tumors
- Head and Neck Surgical Oncology
- Radiopharmaceutical Chemistry and Applications
- Spine and Intervertebral Disc Pathology
- Medical Imaging Techniques and Applications
- Brain Metastases and Treatment
- S100 Proteins and Annexins
- Cerebrospinal fluid and hydrocephalus
- Cerebral Venous Sinus Thrombosis
- Neurofibromatosis and Schwannoma Cases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neurobiology of Language and Bilingualism
- Dementia and Cognitive Impairment Research
- Management of metastatic bone disease
- Spinal Hematomas and Complications
- Cholesterol and Lipid Metabolism
- Spinal Fractures and Fixation Techniques
Cornell University
2019-2025
Weill Cornell Medicine
2019-2025
Presbyterian Hospital
2019-2024
New York Hospital Queens
2019-2024
NewYork–Presbyterian Hospital
2019-2024
Creative Commons
2022
Icahn School of Medicine at Mount Sinai
2011-2015
Oklahoma City University
1988
University of Oklahoma
1988
Meningiomas are the most common primary intracranial tumors, typically treated with surgery and adjuvant radiation in cases of subtotal resection and/or higher histopathologic grade. Contrast-enhanced magnetic resonance imaging (MRI) is gold standard for postoperative assessment treatment planning. However, MRI can have limited accuracy particularly presence posttreatment change. [68Ga]-DOTATATE a Positron Emission Tomography (PET) radiotracer targeting somatostatin receptor 2A (SSTR2A)....
Abstract Background Our purpose was to determine the utility of [68Ga]-DOTATATE PET/MRI in meningioma response assessment following radiosurgery. Methods Patients with prospectively underwent postoperative DOTATATE PET/MRI. Co-registered PET and gadolinium-enhanced T1-weighted MRI were employed for radiosurgery planning. Follow-up performed at 6–12 months post-radiosurgery. Maximum absolute standardized uptake value (SUV) SUV ratio (SUVRSSS) referencing superior sagittal sinus (SSS) blood...
Meningiomas express high levels of somatostatin receptor 2 (SSTR2). SSTR2-targeted PET imaging with [68Ga]-DOTATATE can aid distinguishing residual meningioma from reactive changes in the postoperative setting. We present initial dosimetric analyses, acute events, and local control data utilizing PET/MRI-assisted target delineation for prospectively-treated intermediate-risk meningiomas.Twenty-nine patients underwent DOTATATE PET/MRI evaluation 2019. Eight 9 meningiomas met RTOG 0539...
Abstract Multiple approaches with [ 68 Ga]-DOTATATE, a somatostatin analog PET radiotracer, have demonstrated clinical utility in evaluation of meningioma but not been compared directly. Our purpose was to compare diagnostic performance different quantitative brain Ga]-DOTATATE PET/MRI analysis patients suspected recurrence and establish the optimal threshold for each method. Patients were imaged prospectively PET/MRI. Lesions classified as meningiomas post-treatment change (PTC), using...
<title>Abstract</title> Purpose To report incidence, typology and treatment outcomes of spinal CSF leaks in patients with spontaneous intracranial hypotension (SIH). Methods In this IRB approved study, SIH myelogram-confirmed leak location, who underwent between 2021–2023 at a single institution were retrospectively analyzed. The outcome variable was definitive SIH. Leak type classification was: Type 1 = ventral dural tear, 2 meningeal diverticulum leak, 3 CSF-venous fistula. Results 32...
While contrast-enhanced MR imaging is the criterion standard in meningioma diagnosis and treatment response assessment, gallium
Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare sinonasal neuroectodermal malignancy with slow onset of symptoms, favorable 5-year survival, and propensity for delayed locoregional recurrence. Current treatment options include resection, adjuvant radiotherapy, and/or chemotherapy; however, because its rarity location, determining the optimal ENB has been challenging.ENBs strongly express somatostatin receptors (SSTRs), particularly SSTR2, providing molecular...
A 77-year-old woman presented with headache and confusion. Computed tomography of the head demonstrated an acute left falcine tentorial subdural hemorrhage. Magnetic resonance imaging brain additionally showed sulcal hyperintensity on postcontrast T2-fluid attenuated inversion recovery images throughout posterior hemisphere associated leptomeningeal enhancement. 6 weeks later progression these radiologic changes, prompting biopsy, which confirmed cerebral amyloid angiopathy-related...
Coronavirus Disease 2019 (COVID-19) has posed incredible new challenges for radiology residency programs, including resident training under tenuous and uncertain conditions, barriers to communication, deployment-induced anxiety, social isolation. Chief residents program leadership play a critical role in guiding through these unprecedented times. Best practices creative approaches experienced single institution's located New York City are shared an effort encourage other programs struggling...
Purpose To evaluate dynamic gallium 68 (68Ga) tetraazacyclododecane tetraacetic acid octreotate (DOTATATE) brain PET/MRI as an adjunct modality in meningioma, enabling multiparametric standardized uptake value (SUV) and Patlak net binding rate constant (Ki) imaging, to optimize static acquisition period. Materials Methods In this prospective study (ClinicalTrials.gov no. NCT04081701, DOMINO-START), 68Ga-DOTATATE PET/MRI–derived time-activity curves (TACs) were measured 84 volumes of interest...
Meningiomas, the most common primary intracranial tumor, are vascular neoplasms that express somatostatin receptor-2 (SSTR2). The purpose of this investigation was to evaluate if a relationship exists between tumor vascularity and SSTR2 expression, which may play role in meningioma prognostication clinical management. Gallium-68-DOTATATE PET/MRI with dynamic contrast-enhanced (DCE) perfusion prospectively performed. Clinical demographic patient characteristics were recorded. Tumor volumes...
OBJECTIVE There is a need for advanced imaging biomarkers to improve radiation treatment planning and response assessment. T1-weighted dynamic contrast-enhanced perfusion MRI (DCE MRI) allows quantitative assessment of tissue blood-brain barrier dysfunction has entered clinical practice in the management primary secondary brain neoplasms. The authors sought retrospectively investigate DCE parameters meningiomas treated with resection adjuvant therapy using volumetric segmentation. METHODS A...
Cervical epidural steroid injections are commonly performed to manage pain from cervical spine disease. Cadaveric studies have demonstrated incomplete ligamentum flavum fusion in the central interlaminar region with resultant midline gaps. We an MR-based characterization of gaps improve understanding their prevalence and guide interventionalists procedural planning.Fifty patients were retrospectively reviewed following institutional review board approval. Axial T2-weighted spinecho sequences...