A5032158313- Radiology practices and education
- Neurosurgical Procedures and Complications
- Innovations in Medical Education
- Neurological Complications and Syndromes
- Diversity and Career in Medicine
- Intracerebral and Subarachnoid Hemorrhage Research
- Moyamoya disease diagnosis and treatment
- Radiation Dose and Imaging
- Glioma Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Cerebrovascular and Carotid Artery Diseases
- Pharmacological Effects and Toxicity Studies
- Alzheimer's disease research and treatments
- Cardiovascular Health and Disease Prevention
- Head and Neck Surgical Oncology
- Healthcare professionals’ stress and burnout
- Cerebrospinal fluid and hydrocephalus
- Retinal and Optic Conditions
- Traumatic Brain Injury and Neurovascular Disturbances
- Radiomics and Machine Learning in Medical Imaging
- Effects of Radiation Exposure
- Neurological disorders and treatments
- Radiopharmaceutical Chemistry and Applications
- Pregnancy and preeclampsia studies
New York Hospital Queens
2012-2024
Cornell University
2015-2024
NewYork–Presbyterian Hospital
2012-2024
Presbyterian Hospital
2012-2024
Weill Cornell Medicine
2016-2024
Indiana State University
2023
Memorial Sloan Kettering Cancer Center
2014
Albert Schweitzer Klinik
2013
Howard Hughes Medical Institute
2008-2012
Icahn School of Medicine at Mount Sinai
2007-2012
Background Melanin pigments are ubiquitous in nature. Melanized microorganisms often the dominating species certain extreme environments, such as soils contaminated with radionuclides, suggesting that presence of melanin is beneficial their life cycle. We hypothesized ionizing radiation could change electronic properties and might enhance growth melanized microorganisms. Methodology/Principal Findings Ionizing irradiation changed electron spin resonance (ESR) signal melanin, consistent...
Summary Melanized microorganisms are often found in environments with very high background radiation levels such as nuclear reactor cooling pools and the destroyed Chernobyl. These findings laboratory observations of resistance melanized fungi to ionizing suggest a role for this pigment radioprotection. We hypothesized that radioprotective properties melanin result from combination physical shielding quenching cytotoxic free radicals. have investigated by subjecting human pathogenic...
To assess quantitative susceptibility mapping (QSM) in the depiction of subthalamic nucleus (STN) by using 3-T magnetic resonance (MR) imaging.This study was HIPAA compliant and institutional review board approved. Ten healthy subjects (five men, five women; mean age, 24 years ± 3 [standard deviation]; age range, 21-33 years) eight patients with Parkinson disease three 57 14; 25-69 who were referred neurologists for preoperative navigation MR imaging prior to deep brain stimulator placement...
The diagnosis of amyotrophic lateral sclerosis (ALS) and primary (PLS) is often difficult because a lack disease biomarkers. purpose this study was to investigate quantitative susceptibility mapping (QSM) the motor cortex as potential biomarker for ALS PLS.From retrospective database, QSM images 16 patients with upper neuron (nine men [56%], seven women; mean age, 56.3 years; 12 ALS, four PLS) 23 control (13 10 56.6 years) were reviewed. Two neuroradiologists, blinded diagnosis,...
Melanin, a high-molecular weight pigment that is ubiquitous in nature, protects melanized microorganisms against high doses of ionizing radiation. However, the physics melanin interaction with radiation unknown.
<h3>SUMMARY:</h3> CSF-venous fistula is an important treatable cause of spontaneous intracranial hypotension that often difficult to detect using traditional imaging techniques. Herein, we describe the technical aspects and diagnostic performance MR myelography when used for identifying fistulas. We report 3 cases in which was occult on CT but readily detected myelography.
Melanoma is a cancer with rising incidence, and metastatic disease almost always lethal. We investigated the feasibility of targeting melanin, an intracellular melanocyte pigment, to deliver cytotoxic radiation human melanoma cells in vivo by using melanin-binding mAb (6D2). Nude mice bearing MNT1 pigmented tumors were treated 6D2 labeled 1.5 mCi (1 Ci = 37 GBq) β-emitter 188-Rhenium ( 188 Re) manifested inhibition tumor growth prolonged survival. bound melanin demonstrated no...
There is a need for radioprotectors that protect normal tissues from ionizing radiation in patients receiving high doses of and during nuclear emergencies. We investigated the possibility creating an efficient oral radioprotector based on natural pigment melanin would act as internal shield via Compton scattering followed by free radical scavenging. CD-1 mice were fed melanin-containing black edible mushrooms Auricularia auricila-judae before 9 Gy total body irradiation. The location...
Epidermal growth factor receptor amplification is a common molecular event in glioblastomas. The purpose of this study was to examine the potential usefulness morphologic and diffusion MR imaging signs prediction epidermal gene status patients with glioblastoma.We analyzed pretreatment scans from 147 consecutive newly diagnosed glioblastoma correlated features tumor status. following were qualitatively assessed: 1) border sharpness, 2) cystic/necrotic change, 3) hemorrhage, 4) T2-isointense...
A 77-year-old woman presented with headache and confusion. Computed tomography of the head demonstrated an acute left falcine tentorial subdural hemorrhage. Magnetic resonance imaging brain additionally showed sulcal hyperintensity on postcontrast T2-fluid attenuated inversion recovery images throughout posterior hemisphere associated leptomeningeal enhancement. 6 weeks later progression these radiologic changes, prompting biopsy, which confirmed cerebral amyloid angiopathy-related...
Despite being declared a public health crisis and receiving much attention in recent years, physician burnout continues to worsen (1–5). A unique work-related syndrome defined by the 11th revision of International Classification Diseases, is characterized feelings energy depletion, increased mental distance from one's job or cynicism, reduced professional efficacy, it has been noted have negative personal, professional, institutional, patient-care-related outcomes (6).
The incidence of melanoma is rising, and therapeutic options for metastatic are limited. We report the results experimental therapy with 188-Rhenium-labeled melanin-binding decapeptide (188RE-HYNIC-4B4) a comprehensive safety evaluation this treatment. 188RE-HYNIC- 4B4 bound only to nonviable eumelanotic MNT1 pheomelanotic SK-28-MEL human cells in vitro, as determined by immunofluorescence, which consistent inaccessibility intracellular melanin live cells, suggests specificity tumors...