A5101668918- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Radiation Detection and Scintillator Technologies
- Medical Imaging Techniques and Applications
- Head and Neck Cancer Studies
- Nuclear Physics and Applications
- Breast Cancer Treatment Studies
- Semiconductor materials and devices
- Radiation Effects in Electronics
- Management of metastatic bone disease
- Boron Compounds in Chemistry
- Health Systems, Economic Evaluations, Quality of Life
- Thin-Film Transistor Technologies
- Copper Interconnects and Reliability
- Advanced X-ray and CT Imaging
- Protein purification and stability
- melanin and skin pigmentation
- Polyamine Metabolism and Applications
- Effects of Radiation Exposure
- Wireless Power Transfer Systems
- Monoclonal and Polyclonal Antibodies Research
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Abdominal Trauma and Injuries
- Diet and metabolism studies
New York Proton Center
2022-2024
National Tsing Hua University
1988-2023
St. Jude Children's Research Hospital
2023
ProCure (United States)
2016-2020
Thomas Cole Historic House
2019
Taipei Medical University Hospital
2015
Columbia University
2012
Albert Einstein College of Medicine
2008-2011
Montefiore Medical Center
2009-2011
Yeshiva University
2010
Experimental measurements of two-dimensional (2D) dose rate distributions in proton pencil beam scanning (PBS) FLASH radiation therapy (RT) are currently lacking. In this study, we characterize a newly designed 2D strip-segmented ionization chamber array (SICA) with high spatial and temporal resolution demonstrate its applications modern PBS delivery system at both conventional ultrahigh rates.A dedicated research beamline the Varian ProBeam was employed to deliver 250-MeV nozzle currents up...
Melanin, a high-molecular weight pigment that is ubiquitous in nature, protects melanized microorganisms against high doses of ionizing radiation. However, the physics melanin interaction with radiation unknown.
The transmission proton FLASH technique delivers high doses to the normal tissue distal target, which is less conformal compared Bragg peak technique. To investigate radiotherapy (RT) planning using single-energy beams with a similar beam arrangement as clinical intensity-modulated therapy (IMPT) in liver stereotactic body radiation (SBRT) and characterize plan quality, dose sparing of organs-at-risk (OARs), rate percentage.An in-house platform was developed enable inverse IMPT-FLASH peaks....
PURPOSE: To determine the findings on ventilation-perfusion (V-P) scintigrams, computed tomographic (CT) scans, and chest radiographs correlate them with pulmonary function test results in patients lymphangioleiomyomatosis. MATERIALS AND METHODS: V-P scintigraphy, radiography, conventional thin-section CT, tests were performed 39 patients. The images graded a scale of 0 (normal) to 3 (severely abnormal). RESULTS: Imaging abnormalities found 92% ventilation perfusion 79% radiographs, 100% CT...
Abstract Background The potential reduction of normal tissue toxicities during FLASH radiotherapy (FLASH‐RT) has inspired many efforts to investigate its underlying mechanism and translate it into the clinic. Such investigations require experimental platforms FLASH‐RT capabilities. Purpose To commission characterize a 250 MeV proton research beamline with saturated nozzle monitor ionization chamber for small animal experiments. Methods A 2D strip array (SICA) high spatiotemporal resolution...
Abstract Objective . To investigate the effects of respiratory motion on delivered dose in context proton pencil beam scanning (PBS) transmission FLASH radiotherapy (FLASH-RT) by simulation and phantom measurements. Approach An in-house code was employed to perform silico 2D distributions for clinically relevant PBS FLASH-RT treatments. A moving grid introduced impacts various treatment delivery parameters dynamic delivery. strip-ionization chamber array detector an IROC platform were...
Abstract Background Several studies have shown pencil beam scanning (PBS) proton therapy is a feasible and safe modality to deliver conformal ultra‐high dose rate (UHDR) FLASH radiation therapy. However, it would be challenging burdensome conduct the quality assurance (QA) of along with conventional patient‐specific QA (psQA). Purpose To demonstrate novel measurement‐based psQA program for UHDR PBS transmission radiotherapy (FLASH‐RT) using high spatiotemporal resolution 2D strip ionization...
Purpose: Sharp dose fall off outside a tumor is essential for high single fraction stereotactic radiosurgery (SRS) plans. This study explores the relationship among inhomogeneity, conformity, and in normal tissues micromultileaf collimator (mMLC) linear accelerator (LINAC) based cranial SRS Methods: Between January 2007 July 2009, 65 patients with lesions were treated LINAC‐based SRS. Among them, tumors had maximum diameters : 31; between 20 30 mm: 21; 13. All 6 MV photons on Trilogy ®...
Our purpose was to evaluate the measurement properties of patient-reported outcome (PRO) measures used in ongoing RadComp pragmatic randomized clinical trial (PRCT).
The dose distributions from proton pencil beam scanning were calculated by FLUKA, GEANT4, MCNP, and PHITS, in order to investigate their applicability radiotherapy. first studied case was the integrated depth curves (IDDCs), respectively a 100 226-MeV impinging water phantom. IDDCs agree with each other as long code employs 75 eV for ionization potential of water. second considered similar condition but energies Gaussian distribution. comparison measurement indicates inter-code differences...
The spot characteristics for proton pencil beam scanning (PBS) were measured and analyzed over a 16 month period, which included one major site configuration update six cyclotron interventions. results provide reference to establish the quality assurance (QA) frequency tolerance scanning.A simple treatment plan was generated produce an asymmetric 9-spot pattern distributed throughout field of × 18 cm each energies (100.0-226.0 MeV). delivered fluence distribution in air using phosphor screen...
We investigate two margin-based schemes for optimization target volumes (OTV), both isotropic expansion (2 mm) and beam-specific OTV, to account uncertainties due the setup errors range in pancreatic stereotactic pencil beam scanning (PBS) proton therapy. Also, as 2-mm being one of extreme sizes margin, we also study whether plan quality uniform could be comparable other schemes.
Purpose: The study evaluates the efficacy of cone-beam computed tomography (CBCT)-based synthetic CTs (sCT) as a potential alternative to verification CT (vCT) for enhanced treatment monitoring and early adaptation in proton therapy. Methods: Seven common sites were studied. Two sets sCT per case generated: direct-deformed (DD) image-correction (IC) sCT. image qualities dosimetric impact compared same-day vCT. Results: agreed with vCT regions homogeneous tissues such brain breast; however,...
Abstract Background Quality assurance (QA) for ultra‐high dose rate (UHDR) irradiation is a crucial aspect in the emerging field of FLASH radiotherapy (FLASH‐RT). This innovative treatment approach delivers radiation at UHDR, demanding careful adoption QA protocols and procedures. A comprehensive understanding beam properties dosimetry consistency vital to ensure safe effective delivery FLASH‐RT. Purpose To develop pre‐treatment program cyclotron‐based proton pencil scanning (PBS) Establish...
A study was performed to verify that the prevalence of alcohol abuse and dependence in Formosan aborigines differs from Taiwanese (Chinese Han people), using analysis aldehyde dehydrogenase (ALDH) isozymes flush patterns on randomly sampled 70 Atayal, 66 Paiwan, 61 Yami 94 subjects were studied. The activity an isomer ALDH having a low Km (ALDH-I) hair roots analysed by isoelectric focusing assay. subjective experience flushing response after ingestion assessed. Results showed rate ALDH-I...
Electrical, magnetic and crystallographic measurements have been carried out for the pseudoquaternary ( Nd 1−x Pr x ) Ba 2 Cu 3 O 7−δ system. Orthorhombic phase persists from = 0.0 up to 0.7 transforms into tetragonal structure only ≥ 0.8. Superconducting transition temperature T c decreases linearly 92 K below 10 0.3 extrapolated 0 around 0.35. Magnetic susceptibility data indicates that valence of ion is close 4+. 4+ a very powerful oxidizing agent may distort or move oxygen away Cu-O...
A model based on the electromigration-induced resistance change was used to analyze noise characteristics of aluminum thin-film resistors, and 1/ f 2 power spectrum derived theoretically from rate equation change. Experiments were performed samples stressed with a current density 1 × 10 6 A/cm at 125°C for 50 hours. The measured indeed showed results analyzed quantitatively model.
This paper examines the importance of unit analysis selected for trip generation modelling when model estimation data are collected in a household travel survey. The reviews literature on arguments made use "individual" or "household" as production modelling, and then through statistical exposition it determines what should be appropriate analysis. An empirical test forecast performance household- person-trip models is conducted using household-travel-behaviour survey Greater Toronto Area...