A5007002387- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Ion channel regulation and function
- Pharmacology and Obesity Treatment
- Neuroendocrine regulation and behavior
- Musculoskeletal pain and rehabilitation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Acupuncture Treatment Research Studies
- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Neuroscience and Neuropharmacology Research
- Anesthesia and Pain Management
- Neuropeptides and Animal Physiology
- Spine and Intervertebral Disc Pathology
- Pain Management and Opioid Use
- Automotive and Human Injury Biomechanics
- AI in cancer detection
- Exercise and Physiological Responses
- Mindfulness and Compassion Interventions
- Anesthesia and Neurotoxicity Research
- Receptor Mechanisms and Signaling
- Transportation Safety and Impact Analysis
- Marine Invertebrate Physiology and Ecology
- Health, psychology, and well-being
- Health disparities and outcomes
National Center for Complementary and Integrative Health
2015-2024
National Institutes of Health
2015-2024
University of Bridgeport
2022
Sahlgrenska University Hospital
2016
McGill University
2004-2012
The multidimensional nature of chronic pain is not reflected by definitions based solely on duration, resulting in high prevalence estimates limiting effective policy development. newly proposed concept high-impact (HICP) incorporates both disability and duration to identify a more severely impacted portion the population yet remains uncharacterized at level. As such, we used 2011 National Health Interview Survey (N = 15,670) 1) assess likelihood overall population, 2) estimate HICP, 3)...
The opioid system plays a critical role in both the experience and management of pain. Although acute activation can lead to pain relief, effects chronic on remain opaque. Cross-sectional positron emission tomography (PET) studies show reduced availability brain receptors patients with but are unable (1) determine whether these changes due itself or preexisting medication-induced differences endogenous system, (2) identify neurobiological substrate receptor availability. We investigated...
Chronic pain occurs when normally protective acute becomes pathologically persistent. We examined here whether an isoform of protein kinase C (PKC), PKMζ, that underlies long-term memory storage in various brain regions, also sustains nociceptive plasticity spinal cord dorsal horn (SCDH) mediating persistent pain.
Significance Distinct cellular stresses converge on the translation initiation factor, eukaryotic factor 2α (eIF2α) to modulate rate of protein synthesis. Increased phosphorylation eIF2α has been described in peripheral neurons from neuropathic and diabetic rats. However, role pain not reported. Here we show that controls thermal, but mechanical, sensation via modulation activity a major heat transducer, transient receptor potential vanilloid 1. We also find chronic inflammation-induced...
Activation of the mechanistic/mammalian target rapamycin (mTOR) kinase in models acute and chronic pain is strongly implicated mediating enhanced translation hyperalgesia. However, molecular mechanisms by which mTOR regulates nociception remain unclear. Here we show that deletion eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), a major downstream effector, represses eIF4E activity cap-dependent translation, leads to mechanical, but not thermal hypersensitivity. Mice lacking 4E-BP1...
Abstract With the increased interest in longitudinal brain imaging of awake rodents, it is important to understand both short-term and long-term effects restraint on sensory emotional processing brain. To repeated pain behaviors stress responses, we modeled a protocol similar those used habituate rodents for magnetic resonance scanning, studied sensitivity hormone responses over 5 days. uncover lasting training, also looked at formalin test 2 weeks later. We found that while causes acute...
Abstract The sensation of pressure allows us to feel sustained compression and body strain. While our understanding cutaneous touch has grown significantly in recent years, how deep tissue sensations are detected remains less clear. Here, we use quantitative sensory evaluations patients with rare disorders, as well nerve blocks typical individuals, probe the neural genetic mechanisms for detecting non-painful pressure. We show that ability perceive innocuous pressures is lost when myelinated...
Background: The Na + , K 2Cl − type I cotransporter (NKCC1) and TRPV1 receptors, at the level of dorsal horn, have been implicated in mediating allodynia response to an inflammatory insult. NKCC1 regulates intracellular [Cl ] thus magnitude polarity GABA A receptor responses neurons. receptors transduce diverse chemical natural stimuli nociceptors are critical for hyperalgesia. Results: Here we tested role spinal cotransporters referred a model visceral hyperalgesia mice. Intrathecal (IT)...
Aerobic exercise improves outcomes in a variety of chronic health conditions, yet the support for exercise-induced effects on pain humans is mixed. Although many rodent studies have examined persistent hypersensitivity, most used forced paradigms that are known to be highly stressful. Because stress can also produce analgesic effects, we studied how voluntary exercise, reduce healthy subjects, alters stress, and swelling rat model hind paw inflammation. Our data indicate rapidly effectively...
Abstract Inflammatory pain is thought to induce functional plasticity of spinal dorsal horn neurons and may produce changes in glutamate receptor expression. Plasticity group I metabotropic receptors (mGluR1 mGluR5) important various neuronal systems, these are also known modulate nociceptive neurotransmission the horn. The present study aimed at determining whether persistent inflammatory produces alterations intracellular plasma membrane‐associated mGluR1α mGluR5 cord Persistent...
The Na(+), K(+), 2Cl(-) co-transporter type 1 (NKCC1) plays a pivotal role in hyperalgesia associated with inflammatory stimuli. NKCC1 contributes to maintain high [Cl(-)](i) dorsal root ganglia (DRG) neurons which cause primary afferent depolarization (PAD) when GABA(A) receptors are activated. Enhanced GABA-induced depolarization, through increased activity, has been hypothesized produce orthodromic spike activity of sufficient intensity account for touch-induced pain. In the present...
Abstract Complementary and integrative health approaches can improve well‐being, as well play an important role in disease prevention. The concept of whole person builds on these concepts by empowering individuals, families, communities, populations to their multiple interconnected domains: biological, behavioural, social, environmental. Research involves studies biological systems complex prevention treatment. Some may involve methods diagnosis therapy that differ from those used...
We assessed effectiveness of Fascial Manipulation (FM) in reducing densification thickness and associated acute pain normal humans. densifications were identified using palpation measured with diagnostic ultrasound within self-reported painful somatic regions. Pain intensity ratings obtained response to deep the region before after a brief FM intervention. Brief resulted reduced as well intensity. Sex differences found neither nor at any time point. However, statistically significant...
Visceral pain has a greater emotional component than somatic pain. To determine if the stress-induced analgesic response is differentially expressed in visceral versus states, we studied effects of mild social stressor either acute or states mice. We show that presence an unfamiliar conspecific mouse (stranger) adjacent cubicle standard transparent observation box produced elevated plasma corticosterone levels compared with mice tested alone, suggesting mere stranger stressful. then observed...
Background: Our conventional approach to health care tends separate patients’ by body system, treating each independently and “efficiently”—e.g., minimal time with a provider, reliance on medications, little investment support behavioral lifestyle improvements. Meanwhile, the United States has most expensive in world, some of worse outcomes. Purpose In this paper, we make case for transforming from disease-centric “whole person” model. Research Design: We provide detailed utilization...
Urine from pro-œstrus female rodents evokes increased levels of sexually-motivated behaviors in males, including sniffing and scent marking the urine spot as well activation brain reward regions. Stressors such social defeat can adversely impact behavior male rodents, an effect that be mitigated with anti-depressant drugs. Persistent pain is also known to a potent stressor, producing elevated plasma corticosterone reduced sucrose preference interaction. However, persistent on unknown. Here,...