A5045368557- Vagus Nerve Stimulation Research
- Pain Management and Placebo Effect
- EEG and Brain-Computer Interfaces
- Sexual function and dysfunction studies
- Heart Rate Variability and Autonomic Control
- Erythrocyte Function and Pathophysiology
- Neurological disorders and treatments
- Pain Mechanisms and Treatments
- Urinary Bladder and Prostate Research
- Empathy and Medical Education
- Evolutionary Psychology and Human Behavior
- Ion channel regulation and function
- Functional Brain Connectivity Studies
- Botulinum Toxin and Related Neurological Disorders
- Pelvic floor disorders treatments
- Marine Invertebrate Physiology and Ecology
- Psychosomatic Disorders and Their Treatments
- Psychological Treatments and Assessments
- Neuroscience and Neural Engineering
- Chemical and Physical Studies
- Action Observation and Synchronization
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Motor Control and Adaptation
- Meta-analysis and systematic reviews
- Vascular anomalies and interventions
National Center for Complementary and Integrative Health
2017-2024
National Institutes of Health
2017-2023
Government of the United States of America
2023
Rutgers, The State University of New Jersey
2011-2020
Medical University of South Carolina
2020
Despite the potential importance of genital mechanosensation for sexual reproduction, little is known about how perineal touch influences mating. We explored affords exquisite awareness genitals and controls reproduction in mice humans. Using genetic strategies vivo functional imaging, we demonstrated that mechanosensitive ion channel PIEZO2 (piezo-type component 2) necessary behavioral sensitivity to touch. function needed triggering a touch-evoked erection reflex successful mating both...
Differences in fMRI resting-state connectivity of the default mode network (DMN) seen chronic pain patients are often interpreted as brain reorganization due to condition. Nevertheless, patients' at time might influence DMN because pain, like cognitive stimuli, engages attentional mechanisms and engagement is known alter activity. Here, we aimed dissociate condition (trait) from current experience (state) on with fibromyalgia (FM). We performed scans test FM matched healthy controls two...
Abstract The sensation of pressure allows us to feel sustained compression and body strain. While our understanding cutaneous touch has grown significantly in recent years, how deep tissue sensations are detected remains less clear. Here, we use quantitative sensory evaluations patients with rare disorders, as well nerve blocks typical individuals, probe the neural genetic mechanisms for detecting non-painful pressure. We show that ability perceive innocuous pressures is lost when myelinated...
During the course of a previous study, our laboratory made serendipitous finding that just thinking about genital stimulation resulted in brain activations overlapped with, and differed from, those generated by physical stimulation.This study extends findings further characterizing how differentially processes 'touch' 'imagined' stimulation.Eleven healthy women (age range 29-74) participated an fMRI response to imagined or actual tactile nipple clitoris. Two additional conditions - dildo...
Humans have a distinguishing ability for fine motor control that is subserved by highly evolved cortico-motor neuronal network. The acquisition of particular skill involves long series practice movements, trial and error, adjustment refinement. At the cortical level, this begins in parieto-temporal sensory regions subsequently consolidated stratified premotor-motor cortex. Task-specific dystonia can be viewed as corruption or loss confined to single skill. Using multimodal experimental...
There is preclinical and clinical evidence that vagus nerve stimulation modulates both pain mood state. Mechanistic studies show brainstem circuitry involved in modulation by stimulation, but little known about possible indirect descending effects of altered state on perception. This possibility important, since previous have shown affects pain, particularly the affective dimension (pain unpleasantness). To date, human investigating perception not reliably measured psychological factors to...
The PIEZO2 ion channel is critical for transducing light touch into neural signals but not considered necessary acute pain in humans. Here, we discovered an exception – a form of mechanical evoked by hair pulling. Based on observations rare group individuals with deficiency syndrome, demonstrated that hair‐pull dependent transduction. Studies control participants showed triggered distinct nocifensive response, including nociceptive reflex. Observations Aβ deafferented and nerve conduction...
Recently a role for the vagus nerve in conditioning food preferences was established rodents. In prospective controlled clinical trial humans, invasive stimulation shifted choice toward lower fat content. Here we explored whether hedonic aspects of an orally sampled stimulus can be modulated by non-invasive transcutaneous (tVNS) humans. healthy participants (n = 10, five women, 20-32 years old, no obesity) tested liking and wanting ratings samples with varying or sugar content without tVNS...
Summary The PIEZO2 ion channel is critical for transducing light touch into neural signals but not considered necessary acute pain in humans. Here, we discovered an exception – a form of mechanical evoked by hair pulling. Based on observations rare group individuals with deficiency syndrome, demonstrated that hair-pull dependent transduction. Studies control participants showed triggered distinct nocifensive response, including nociceptive reflex. Observations Aβ deafferented and nerve...
Placebo analgesia is hypothesized to involve top-down engagement of prefrontal regions that access endogenous pain inhibiting opioid pathways. Fibromyalgia (FM) patients have neuroanatomical and neurochemical alterations in pathways relevant placebo analgesia. Thus, it remains unclear whether analgesic mechanisms would differ FM compared healthy controls (HCs). Here, using placebo-analgesia-inducing paradigms included verbal suggestions conditioning manipulations, we examined behavioral...
Little is known about the perceptions and attitudes of participants who volunteer in studies involving authorized deception. Thus, this cross-sectional pilot study measured, for first time, participation an authorized-deception placebo analgesia chronic pain patients with fibromyalgia assessed whether their differed from healthy controls.An anonymous survey questions trust research willingness to participate future deception was mailed both groups after completion parent study. Statistical...