A5005109981- Neuroendocrine regulation and behavior
- Attention Deficit Hyperactivity Disorder
- Neuroscience and Neuropharmacology Research
- Erythrocyte Function and Pathophysiology
- Neurotransmitter Receptor Influence on Behavior
- Animal Ecology and Behavior Studies
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Herbal Medicine Research Studies
- Exercise and Physiological Responses
- Biochemical effects in animals
- Ion channel regulation and function
- Medicinal Plants and Neuroprotection
- Complementary and Alternative Medicine Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Phytochemicals and Medicinal Plants
- Cholinesterase and Neurodegenerative Diseases
- Olfactory and Sensory Function Studies
- Spaceflight effects on biology
- Botulinum Toxin and Related Neurological Disorders
- Chemical and Physical Studies
- 3D Printing in Biomedical Research
- Pain Mechanisms and Treatments
- Animal Behavior and Welfare Studies
Linköping University
2023-2024
Cadi Ayyad University
2017-2022
Inserm
2017-2021
Institut de Neurosciences des Systèmes
2017-2021
Many experimental approaches require housing rodents in individual cages, including epilepsy research. However, rats and mice are social animals; constitutes a stressful situation. The goal of the present study was to determine effects as compared conditions maintaining contact on stress markers epilepsy. Control male socially housed during pretest then transferred cages for six weeks displayed anhedonia, increased anxiety biological values or kept weeks. Pilocarpine (pilo)-treated together...
Anacyclus pyrethrum (L.) is a plant widely used in Moroccan traditional medicine to treat inflammatory and painful diseases. The objective of the present study was evaluate antinociceptive, anti-inflammatory antioxidant activities aqueous methanol extracts roots (AEAPR MEAPR). effect AEAPR MEAPR determined xylene-induced ear edema Complete Freund's Adjuvant (CFA)-induced paw edema. antinociceptive activity (125, 250, 500 mg/kg) administered by gavage examined mice using acetic acid-induced...
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental characterized by impaired attention, impulsivity and hyperactivity. The "neonatal 6-hydroxydopamine" (6-OHDA) lesion commonly used model of ADHD in rat. However, comprehensive assessment ADHD-like symptoms still missing, data mouse remain largely unavailable. Our aim was to analyse the neonatal 6-OHDA model. mice exhibited major symptoms, i.e. hyperactivity (open field), attention deficit (five-choice serial...
Clinical evidence suggests that pain hypersensitivity develops in patients with attention-deficit/hyperactivity disorder (ADHD). However, the mechanisms and neural circuits involved these interactions remain unknown because of paucity studies animal models. We previously validated a mouse model ADHD obtained by neonatal 6-hydroxydopamine (6-OHDA) injection. Here, we have demonstrated 6-OHDA mice exhibit marked sensitization to thermal mechanical stimuli, suggesting phenotypes associated...
Attention-deficit/hyperactivity disorder (ADHD) is a syndrome characterized by impaired attention, impulsivity and hyperactivity in children. These symptoms are often maintained adults. During adolescence, prefrontal cortex develops connectivity with other brain regions to engage executive functions such as, latent inhibition, attention inhibitory control. In our previous work, we demonstrated the validity of neonatal 6-Hydroxydopamine (6-OHDA) mouse model, classical neurodevelopmental model...
The PIEZO2 ion channel is critical for transducing light touch into neural signals but not considered necessary acute pain in humans. Here, we discovered an exception – a form of mechanical evoked by hair pulling. Based on observations rare group individuals with deficiency syndrome, demonstrated that hair‐pull dependent transduction. Studies control participants showed triggered distinct nocifensive response, including nociceptive reflex. Observations Aβ deafferented and nerve conduction...
Summary The PIEZO2 ion channel is critical for transducing light touch into neural signals but not considered necessary acute pain in humans. Here, we discovered an exception – a form of mechanical evoked by hair pulling. Based on observations rare group individuals with deficiency syndrome, demonstrated that hair-pull dependent transduction. Studies control participants showed triggered distinct nocifensive response, including nociceptive reflex. Observations Aβ deafferented and nerve...
Natural secondary metabolites have long served as sources of drugs against various health disorders, among them neurodegenerative diseases especially Alzheimer's disease (AD). Withanolides, isolated from Withania species, shown acetylcholinesterase inhibition activity and their neuroprotective effects may be beneficial in the treatment cholinergic system associated diseases, such AD. This study was undertaken to highlight withaferin A (WA), W. adpressa leaves, using a scopolamine-induced...
Abstract Objective Aqueous extract of Anacyclus pyrethrum (AEAPR) is used in traditional medicine to treat epilepsy, but whether it has antiseizure properties not been established. Because extracts the plant have antioxidant properties, we hypothesized that may be particularly potent conditions associated with oxidative stress, particular social isolation. Methods We addressed these objectives pilocarpine experimental model epilepsy using socially isolated rats maintaining contacts (handled)...
<title>Abstract</title> The diversity of mechanical pain sensations in humans cannot be explained based on our current understanding pain-sensing neural classes the skin. To begin to bridge this gap, we dissected basis a distinct form sensation evoked by hair pulling humans. Based observations rare group individuals with PIEZO2 deficiency syndrome, demonstrated that hair-pull is dependent transduction. Single-unit axonal recordings revealed specific class cooling-responsive, rapidly...
Abstract Recent clinical evidence suggest that pain hypersensitivity develops in subjects with attention deficit hyperactivity disorder (ADHD). However, the mechanisms and neural circuits involved these interactions remain unknown because of paucity studies animal models. In our previous work, we validated a mouse model obtained by neonatal 6-Hydroxydopamine (6-OHDA) injection, to mimic ADHD syndrome. Here, demonstrated 6-OHDA mice exhibited marked decrease withdrawal thresholds thermal...
ABSTRACT Many experimental approaches require housing rodents in individual cages, including epilepsy research. However, rats and mice are social animals; constitutes a stressful situation. The goal of the present study was to determine effects as compared conditions maintaining contact on stress markers epilepsy. Control male socially housed during pretest then transferred cages for six weeks displayed anhedonia, increased anxiety biological values or kept weeks. Pilocarpine-treated...