A5017924055- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Epilepsy research and treatment
- Neuroscience and Neural Engineering
- Neuroendocrine regulation and behavior
- Circadian rhythm and melatonin
- Photoreceptor and optogenetics research
- Mitochondrial Function and Pathology
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Fractal and DNA sequence analysis
- Genetic Neurodegenerative Diseases
- Birth, Development, and Health
- Diet and metabolism studies
- Cholinesterase and Neurodegenerative Diseases
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Conducting polymers and applications
- Nerve injury and regeneration
- Genetics and Neurodevelopmental Disorders
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Animal Ecology and Behavior Studies
Inserm
2015-2025
Institut de Neurosciences des Systèmes
2016-2025
Aix-Marseille Université
2015-2025
Centre de Recherche Jean Pierre Aubert
2009-2014
Institut de Neurobiologie de la Méditerranée
2012
Université Lille Nord de France
2012
Université de Lille
2003
In vivo electrophysiological recordings of neuronal circuits are necessary for diagnostic purposes and brain-machine interfaces. Organic electronic devices constitute a promising candidate because their mechanical flexibility biocompatibility. Here we demonstrate the engineering an organic electrochemical transistor embedded in ultrathin film designed to record signals on surface brain. The device, tested epileptiform discharges, displayed superior signal-to-noise ratio due local...
The autosomal dominant mutation causing myotonic dystrophy (DM1) is a CTG repeat expansion in the 3′-UTR of DM protein kinase (DMPK) gene. This multisystemic disorder includes myotonia, progressive weakness and wasting skeletal muscle extramuscular symptoms such as cataracts, testicular atrophy, endocrine cognitive dysfunction. mechanisms underlying its pathogenesis are complex. Recent reports have revealed that DMPK gene haploinsufficiency may account for cardiac conduction defects whereas...
Abstract Vaccination against human beta‐amyloid peptide (Aβ) has been shown to remove the amyloid burden produced in transgenic mice overexpressing mutated precursor protein (APP) gene. For beings, efficiency of this therapeutic strategy take into account specificities amyloid, especially at early stages ‘sporadic’ Alzheimer's disease (AD). Aβ 40/42 were previously quantified tissues from our well‐established brain bank, including non‐demented individuals with both mild and tau pathologies,...
Enduring, abnormal expression and function of the ion channel hyperpolarization-activated cyclic adenosine monophosphate gated type 1 (HCN1) occurs in temporal lobe epilepsy (TLE). We examined underlying mechanisms, investigated whether interfering with these mechanisms could modify disease course.Experimental TLE was provoked by kainic acid-induced status epilepticus (SE). HCN1 repression at mRNA, protein, functional levels. Chromatin immunoprecipitation employed to identify transcriptional...
Consumption of certain substances during pregnancy can interfere with brain development, leading to deleterious long-term neurological and cognitive impairments in offspring. To test whether modulators adenosine receptors affect neural we exposed mouse dams a subtype-selective type 2A receptor (A2AR) antagonist or caffeine, naturally occurring antagonist, lactation. We observed delayed migration insertion γ-aminobutyric acid (GABA) neurons into the hippocampal circuitry first postnatal week...
An implantable microfluidic ion pump prevents seizures in a mice by delivery of inhibitory neurotransmitters to the seizure source.
Many experimental approaches require housing rodents in individual cages, including epilepsy research. However, rats and mice are social animals; constitutes a stressful situation. The goal of the present study was to determine effects as compared conditions maintaining contact on stress markers epilepsy. Control male socially housed during pretest then transferred cages for six weeks displayed anhedonia, increased anxiety biological values or kept weeks. Pilocarpine (pilo)-treated together...
Gamma oscillations are involved in long-range coupling of distant regions that support various cognitive operations. Here we show adult male rats synchronized bursts gamma bind the hippocampus (HPC) and prefrontal cortex (mPFC) during slow slow-wave sleep, a brain state is central for consolidation memory traces. These entrained firing local HPC mPFC neuronal populations. Neurons nucleus reuniens (NR), which structural functional hub between mPFC, demonstrated specific increase their before...
The primary feature of dementia with Lewy bodies (DLB) is the aggregation alpha-synuclein into characteristic lesions: (LBs) and neurites. However, in most DLB cases, LBs are associated neurofibrillary tangles amyloid plaques (both Alzheimer disease [AD]-related lesions). We wanted to determine if this overlap lesions statistical, as a result late onset both diseases, or results from specific physiopathological synergy between synucleinopathy either tauopathy pathology. All patients our...
One cornerstone event during epileptogenesis is the occurrence of first spontaneous seizure (SZ1). It therefore important to identify biomarkers network alterations leading SZ1. In experimental models temporal lobe epilepsy (TLE), interictal-like activity (ILA) precedes SZ1 by several days. The goal this study was determine whether ILA dynamics bore electrophysiological features signaling impeding transition SZ1.Experimental TLE triggered pilocarpine- or kainic acid-induced status...
Accumulation of stressful events can render individuals susceptible to develop epilepsy and comorbidities. Whether such vulnerability be predicted reversed is not known. Here we show that social defeat, although producing depression by itself, produced in 50% rats reduced threshold for status epilepticus (SE), accelerated epileptogenesis, once was induced, depression-like profile cognitive deficits. Low serum brain-derived neurotrophic factor (BDNF) levels measured before SE identified this...
The cycling of hippocampal genes during the night and day cycle is altered in epilepsy.
Neural electrophysiology is often conducted with traditional, rigid depth probes. The mechanical mismatch between these probes and soft brain tissue unfavorable for interfacing. Making compliant can improve biocompatibility, but as a consequence, they become more difficult to insert into the brain. Therefore, new methods inserting neural must be developed.Here, we present bioresorbable shuttle based on hydrolytically degradable poly(vinyl alcohol) (PVA) poly(lactic-co-glycolic acid) (PLGA)....
Autoclaving, the most widely available sterilization method, is applied to poly(3,4-ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) electrophysiology devices. The process does not harm morphology or electrical properties, while it effectively kills E. coli intentionally cultured on This finding paves way widespread introduction of PEDOT:PSS devices clinic. As a service our authors and readers, this journal provides supporting information supplied by authors. Such...
In the adult brain, activity-dependent myelin plasticity is required for proper learning and memory consolidation. Myelin loss, alteration, or even subtle structural modifications can therefore compromise network activity, leading to functional impairment. multiple sclerosis, spontaneous repair process possible, but it heterogeneous among patients, sometimes recovery, often more visible at motor level than cognitive level. cuprizone-treated mouse model, massive brain demyelination followed...
The nucleus reuniens (NR) is an important anatomic and functional relay between the medial prefrontal cortex (mPFC) hippocampus (HPC). Whether NR controls neuronal assemblies, a hallmark of information exchange HPC mPFC for memory transfer/consolidation, not known. Using simultaneous local field potential unit recordings in NR, HPC, male rats during slow oscillations under anesthesia, we identified reliable sequential activation neurons at beginning UP states, which preceded ones. sequences...
Amyloid precursor protein (APP) dysfunction is a key aetiologic agent in Alzheimer's disease (AD). The processing of this transmembrane generates carboxy terminal fragments (CTFs) upstream beta-amyloid peptide (Abeta) production. physiologic significance APP-CTFs still poorly understood, as well the relationship that could link APP and tau pathology familial non-familial AD (non-FAD). In present study, we have investigated quantitative qualitative changes different brain areas non-demented...
Neuropixels probes have become a crucial tool for high-density electrophysiological recordings. Although most research involving these electrodes is in acute preparations, some scientific inquiries require long-term recordings freely moving animals. Recent reports presented prosthesis designs chronic recordings, but of them do not allow probe recovery, which desirable given their cost. Others appear to be fragile, as articles describe numerous broken implants. This fragility presents...
Neuropixels probes have become a crucial tool for high-density electrophysiological recordings. Although most research involving these is in acute preparations, some scientific inquiries require long-term recordings freely moving animals. Recent reports presented prosthesis designs chronic recordings, but of them do not allow probe recovery, which desirable given their cost. Others appear to be fragile, as articles describe numerous broken implants.Objective.This fragility presents challenge...