A5080097039- Adenosine and Purinergic Signaling
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Gastrointestinal motility and disorders
- Tryptophan and brain disorders
- Vagus Nerve Stimulation Research
- Pharmacology and Obesity Treatment
- Neuroscience of respiration and sleep
- Neuropeptides and Animal Physiology
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Retinal Development and Disorders
- Pesticide Exposure and Toxicity
- Nicotinic Acetylcholine Receptors Study
- Eating Disorders and Behaviors
- Receptor Mechanisms and Signaling
- Salivary Gland Disorders and Functions
- Coffee research and impacts
- Neuroscience and Neural Engineering
University of Coimbra
2013-2024
Instituto Gulbenkian de Ciência
2016
Eötvös Loránd University
2014
Semmelweis University
2013
Consumption of certain substances during pregnancy can interfere with brain development, leading to deleterious long-term neurological and cognitive impairments in offspring. To test whether modulators adenosine receptors affect neural we exposed mouse dams a subtype-selective type 2A receptor (A2AR) antagonist or caffeine, naturally occurring antagonist, lactation. We observed delayed migration insertion γ-aminobutyric acid (GABA) neurons into the hippocampal circuitry first postnatal week...
During development, neural circuit formation requires the stabilization of active γ-aminobutyric acid–mediated (GABAergic) synapses and elimination inactive ones. Here, we demonstrate that, although activation postsynaptic GABA type A receptors (GABAARs) adenosine A2A (A2ARs) stabilizes GABAergic synapses, only A2AR is sufficient. Both GABAAR- A2AR-dependent signaling pathways act synergistically to produce 3′,5′-monophosphate through recruitment calcium–calmodulin–adenylyl cyclase pathway....
Transient retinal ischemia is a major complication of degenerative diseases and contributes to visual impairment blindness. Evidences indicate that microglia-mediated neuroinflammation has key role in the neurodegenerative process, prompting hypothesis control microglia reactivity may afford neuroprotection retina against damage induced by ischemia-reperfusion (I-R). The available therapeutic strategies for have limited potential, but blockade adenosine A2A receptor (A2AR) emerges as...
Adenosine receptors mainly control synaptic function, and excessive activation of adenosine may worsen the onset many neurological disorders. Accordingly, regular intake moderate doses caffeine antagonizes affords robust neuroprotection. Although alters brain functional connectivity multi-omics analyses indicate that modifies metabolic processes, it is unclear how affects behavior, plasticity its modulation by adenosine. We now report male mice drinking caffeinated water (0.3 g/L) for 2...
Background and Purpose Pre‐synaptic nicotinic ACh receptors ( nAChRs ) adenosine A 2A Rs are involved in the control of dopamine release putative therapeutic targets P arkinson's disease addiction. Since have been reported to interact with , here we aimed at mapping possible functional interaction between rat striatal dopaminergic terminals. Experimental Approach We pharmacologically characterized defined localization nAChR subunits nerve terminals vitro carried out locomotor behavioural...
Abstract Persistent forms of plasticity, such as long-term depression (LTD), are dependent on the interplay between activity-dependent synaptic tags and capture plasticity-related proteins. We propose that tag represents a structural alteration turns synapses permissive to change. found modulation actin dynamics has different roles in induction maintenance LTD. Inhibition either depolymerisation or polymerization blocks LTD whereas only inhibition maintenance. Interestingly, we CaMKII...
Coffee intake is increasingly recognized as a life-style factor associated with the preservation of health, but there still debate on relative effects caffeinated and decaffeinated coffee. We now tested how regular drinking coffee for 3 weeks impacted behavior male female adult mice. Males displayed statistically significant lower weight gain, increased sensorimotor coordination, greater motivation in splash test, more struggling forced swimming faster onset nest building, marble burying...
Esfenvalerate belongs to the pyrethroid group of insecticides which display significant selective toxicity against insects compared mammalian species, nevertheless, they may pose health risks, especially in case accidental exposure. The aim present study was model effect acute, relatively high-dose exposure esfenvalerate-containing formulation Sumi-Alpha?. Eventual functional alterations central nervous system and gastrointestinal tract were studied on vitro tissue preparations at different...
Introduction: Both imidazoline receptors and endogenous ligands have been identified throughout the gastrointestinal (GI) tract, but their physiological role remains uncertain. On other hand, functional GI disorders accompanied by motility disturbances (e.g. dyspepsia idiopathic gastroparesis) are common clinical problems new targets for drug development needed. The present study was undertaken to clarify, whether endogeous system takes part in modulation of gastric motility. Methods:...