A5089115150- Electrolyte and hormonal disorders
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Biochemical effects in animals
- Restless Legs Syndrome Research
- Anesthesia and Neurotoxicity Research
- Diet, Metabolism, and Disease
- Sleep and Wakefulness Research
- Organ Transplantation Techniques and Outcomes
- Tryptophan and brain disorders
- Hemoglobinopathies and Related Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion Transport and Channel Regulation
- Parkinson's Disease Mechanisms and Treatments
- Blood disorders and treatments
- Adenosine and Purinergic Signaling
- Mitochondrial Function and Pathology
- Neonatal and fetal brain pathology
- Antioxidant Activity and Oxidative Stress
- Fatty Acid Research and Health
- Renal Diseases and Glomerulopathies
- Magnesium in Health and Disease
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cholesterol and Lipid Metabolism
- Liver Disease Diagnosis and Treatment
University of Coimbra
2020-2023
Washington University in St. Louis
2021
Instituto Português de Oncologia Francisco Gentil
2004
Adenosine receptors mainly control synaptic function, and excessive activation of adenosine may worsen the onset many neurological disorders. Accordingly, regular intake moderate doses caffeine antagonizes affords robust neuroprotection. Although alters brain functional connectivity multi-omics analyses indicate that modifies metabolic processes, it is unclear how affects behavior, plasticity its modulation by adenosine. We now report male mice drinking caffeinated water (0.3 g/L) for 2...
Brain iron deficiency (BID) constitutes a primary pathophysiological mechanism in restless legs syndrome (RLS). BID rodents has been widely used as an animal model of RLS, since it recapitulates key neurochemical changes reported RLS patients and shows RLS-like behavioral phenotype. Previous studies with the BID-rodent demonstrated increased sensitivity cortical pyramidal cells to release glutamate from their striatal nerve terminals driving circuits, correlative finding motor...
Alzheimer's disease (AD), which predominantly affects women, involves at its onset a metabolic deregulation associated with synaptic failure. Here, we performed behavioral, neurophysiological and neurochemical characterization of 9-month-old female APPswe/PS1dE9 (APP/PS1) mice as model early AD. These animals showed learning memory deficits in the Morris water maze, increased thigmotaxis anxiety-like behavior signs fear generalization. Long-term potentiation (LTP) was decreased prefrontal...
Diabetes during pregnancy has been shown to affect the central nervous system (CNS) of offspring, resulting in short- and long-term adverse effects. Children diabetic mothers are more likely develop cognitive impairment, also having increased susceptibility psychiatric disorders. Microglia, immune cells CNS, work as sensors environmental changes, namely metabolic challenges, early intrauterine period. During this period, microglia is actively involved processes neurogenesis, synaptic pruning...
The endocannabinoid system is implicated in a plethora of neuropsychiatric disorders. However, it technically challenging to assess the turnover 2-arachidonoyl glycerol (2-AG), principal molecule brain. Two recent studies showed that diacylglycerol lipase α (DAGLα), an enzyme chiefly responsible for cerebral production 2-AG, also accepts surrogate chromogenic substrate 4-nitrophenyl butyrate (4-NPB). Here, we aimed optimize this spectrophotometric assay ex vivo brain tissue, particular, rat...
Ferreira, T.; Torres, M.; Valença, D.; Rodrigues, Nascimento, S.; Nogueira Neto, J.; Argolo, Lima, C.; Guedes, Sanjuliani, A. Author Information
Nogueira, L.; Knibel, M.; Valença, D.; Rodrigues, Nogueira Neto, J.; Argolo, S.; Torres, Guedes, Lima, C.; Sanjuliani, A. Author Information
Maluly, V.1; Rodrigues, M.1; Valença, D.1; Torres, Argolo, S.2; Nogueira Neto, J.3; Sanjuliani, A.1 Author Information
: Wednesday, June 16, 2004: POSTER SESSIONS: Poster Session 53: Genetics and Molecular Biology
Rodrigues, M.1; Sampaio-Maia, B.1; Henriques-Coelho, T.2; Leite-Moreira, A.2; Pestana, M.1,3 Author Information
1Institute of Pharmacology and Therapeutics, Faculty Medicine, Porto, Portugal 2Dep. Nephrology,