A5090186962- Nitric Oxide and Endothelin Effects
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Antioxidant Activity and Oxidative Stress
- Free Radicals and Antioxidants
- Photoreceptor and optogenetics research
- Traumatic Brain Injury and Neurovascular Disturbances
- Biochemical effects in animals
- Electron Spin Resonance Studies
- Electrochemical sensors and biosensors
- Phytochemicals and Antioxidant Activities
- Gut microbiota and health
- Neurological Disease Mechanisms and Treatments
- Eicosanoids and Hypertension Pharmacology
- Neuroscience of respiration and sleep
- Electrochemical Analysis and Applications
- Neuroscience and Neural Engineering
- Anesthesia and Neurotoxicity Research
- Redox biology and oxidative stress
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Conducting polymers and applications
- Porphyrin and Phthalocyanine Chemistry
- Alzheimer's disease research and treatments
University of Coimbra
2015-2024
Hospital Braga
2024
Centro de Neurociências e Biologia Celular
2012-2022
Hospital Pedro Hispano
2020
Universidade do Porto
2008
University of Kentucky
2005
University of Southern California
2005
Center for Neurosciences
2005
Luteolin efficiently fights intestinal inflammation. The inhibition of the JAK/STAT pathway by luteolin is a key mechanism.
Red wine polyphenols protect the intestinal barrier against inflammatory stimuli by modulating gene expression of key tight junction proteins.
Nitric oxide (NO) is a small molecule with distinct roles in diverse physiological functions biological systems, among them the control of apoptotic signalling cascade. By combining proteomic, genetic and biochemical approaches we demonstrate that NO glyceraldehyde-3-phosphate dehydrogenase (GAPDH) are crucial mediators yeast apoptosis. Using indirect methodologies NO-selective electrode, present results showing H2O2-induced cells synthesize associated to nitric synthase (NOS)-like activity...
Hydrogen peroxide is a major redox signaling molecule underlying novel paradigm of cell function and communication. A role for H2O2 as an intercellular neuromodulator in the brain has become increasingly apparent, with evidence showing this biological oxidant to regulate neuronal polarity, connectivity, synaptic transmission tuning networks. This notion supported by its ability diffuse extracellular space, from source production target. It is, thus, crucial understand concentration dynamics...
Nitric oxide ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} \begin{equation*}^{{\cdot}}{\mathrm{N}}{\mathrm{O}}\end{equation*}\end{document} ) production in response to stimulation of the NMDA glutamate receptor is implicated not only synaptic plasticity hippocampus but may also participate excitotoxic cell death. Using -selective...
The development of new therapeutic approaches, combining efficacy and safety against intestinal inflammation, notably inflammatory bowel disease (IBD), has emerged as an important goal due to the significant side effects lack effectiveness standard current therapies. Recently, several studies described health-promoting red wine, including anti-inflammatory properties, but molecular mechanisms underlying its beneficial role remain largely unknown. Red wine is rich in phenolic compounds it...
Oxidized low density lipoproteins (LDL) are toxic to cultured endothelial cells. Mildly oxidized LDL, characterized by relatively levels of TBARS and only minor modifications apoB, were obtained using 2 experimental model systems oxidation, namely oxidation u.v. radiation or ferrylmyoglobin (a two electron product from the reaction metmyoglobin with H O ). Toxic concentrations mildly LDL induce apoptosis (programmed cell death) cells, as shown typical morphological features, in situ TUNEL...