Leonor M. Almeida

ORCID: 0000-0002-7769-4712
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About
Contact & Profiles
Research Areas
  • Antioxidant Activity and Oxidative Stress
  • Phytochemicals and Antioxidant Activities
  • Lipid Membrane Structure and Behavior
  • Free Radicals and Antioxidants
  • Genomics, phytochemicals, and oxidative stress
  • Sirtuins and Resveratrol in Medicine
  • Porphyrin and Phthalocyanine Chemistry
  • Surfactants and Colloidal Systems
  • Vitamin C and Antioxidants Research
  • Electron Spin Resonance Studies
  • Photodynamic Therapy Research Studies
  • Essential Oils and Antimicrobial Activity
  • Ion channel regulation and function
  • Nitric Oxide and Endothelin Effects
  • Natural Antidiabetic Agents Studies
  • Protein Interaction Studies and Fluorescence Analysis
  • Biochemical Analysis and Sensing Techniques
  • Mitochondrial Function and Pathology
  • Neurological Disease Mechanisms and Treatments
  • Redox biology and oxidative stress
  • Gut microbiota and health
  • Analytical Chemistry and Chromatography
  • Biochemical effects in animals
  • Organoselenium and organotellurium chemistry
  • Medicinal Plants and Bioactive Compounds

University of Coimbra
2013-2022

Centro de Neurociências e Biologia Celular
2017-2021

Laboratoire de Biochimie
2008

Institute of Pharmacology
2005

Universidade Federal de São Carlos
2003

Rede de Química e Tecnologia
1991-2003

Universidade de São Paulo
2003

Universidade Estadual Paulista (Unesp)
2003

Max Planck Institute for Biophysical Chemistry
1984

The potential use of polyphenols in the prevention and treatment chronic inflammatory diseases has been extensively investigated although mechanisms involved cellular signaling need to be further elucidated. Cyanidin-3-glucoside is a typical anthocyanin many pigmented fruits vegetables widespread human diet. In present study, protection afforded by cyanidin-3-glucoside against cytokine-triggered response was evaluated intestinal HT-29 cell line, comparison with 5-aminosalicylic acid,...

10.1371/journal.pone.0073001 article EN cc-by PLoS ONE 2013-09-06

Luteolin efficiently fights intestinal inflammation. The inhibition of the JAK/STAT pathway by luteolin is a key mechanism.

10.1039/c6fo01529h article EN Food & Function 2016-12-14

Red wine polyphenols protect the intestinal barrier against inflammatory stimuli by modulating gene expression of key tight junction proteins.

10.1039/c8fo02469c article EN Food & Function 2019-01-01

Despite the actual therapeutic approaches for inflammatory bowel disease (IBD), efficient and secure alternative options remain a research focus. In this context, anthocyanins seem promising natural anti-inflammatory agents, but their action mechanisms efficacy as compared with established drugs still require more clarification. The main aim of study was to compare chemically characterized anthocyanin-rich fraction (ARF), obtained from Portuguese blueberries (Vaccinium corymbosum L.), that...

10.1371/journal.pone.0174116 article EN cc-by PLoS ONE 2017-03-22

Oxidized low-density lipoproteins (ox-LDL) play a role in the genesis of atherosclerosis. OxLDL are able to induce apoptosis vascular cells, which is potentially involved formation necrotic center atherosclerotic lesions, plaque rupture, and subsequent thrombotic events. Because oxLDL may structural modifications cell protein altered proteins impair viability, present work aimed evaluate extent alterations, degradation modified through ubiquitin-proteasome system (a major degradative pathway...

10.1096/fasebj.14.3.532 article EN The FASEB Journal 2000-03-01

Resveratrol (3,4',5-trihydroxystilbene) is a natural phytoalexin synthesized in response to injury or fungal attack, found the grape skin and wine, specially red wine. A large number of studies have demonstrated that resveratrol regulates many biological activities, namely protection against atherosclerosis by set pharmacological properties, including antioxidant activity. In this study, we explored capacity protecting low density lipoproteins (LDL) either ferrylmyoglobin-...

10.1080/10715760290029083 article EN Free Radical Research 2002-01-01

The development of new therapeutic approaches, combining efficacy and safety against intestinal inflammation, notably inflammatory bowel disease (IBD), has emerged as an important goal due to the significant side effects lack effectiveness standard current therapies. Recently, several studies described health-promoting red wine, including anti-inflammatory properties, but molecular mechanisms underlying its beneficial role remain largely unknown. Red wine is rich in phenolic compounds it...

10.1039/c2fo30233k article EN Food & Function 2012-11-21

Excess production of superoxide (O2−) and nitric oxide (NO) in blood vessel walls may occur early atherogenesis leading to the formation peroxynitrite, a strong oxidant nitrating agent. This study was designed determine effect diphenyl diselenide (PhSe)2, synthetic organoselenium compound, comparison with ebselen, on peroxynitrite-mediated endothelial damage. Experimental results showed that pre-incubation BAEC (24 h) low concentrations (PhSe)2 (0.5 1 μM) protected cells from...

10.1016/j.niox.2013.03.003 article EN publisher-specific-oa Nitric Oxide 2013-03-18

Background Many advances have been recently made focused on the valuable help of dietary polyphenols in chronic inflammatory diseases. On other hand, current treatment options for intestinal bowel disease patients are unsatisfying and, this reason, it is estimated that many use supplements to achieve extra benefits. Aim The aim work was analyze under a mechanistic perspective anti-inflammatory potential resveratrol, natural polyphenolic compound, and compare with pharmaceutical agent,...

10.1371/journal.pone.0109048 article EN cc-by PLoS ONE 2014-10-01
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