A5023879979- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
- Lipid Membrane Structure and Behavior
- Free Radicals and Antioxidants
- Genomics, phytochemicals, and oxidative stress
- Sirtuins and Resveratrol in Medicine
- Porphyrin and Phthalocyanine Chemistry
- Surfactants and Colloidal Systems
- Vitamin C and Antioxidants Research
- Electron Spin Resonance Studies
- Photodynamic Therapy Research Studies
- Essential Oils and Antimicrobial Activity
- Ion channel regulation and function
- Nitric Oxide and Endothelin Effects
- Natural Antidiabetic Agents Studies
- Protein Interaction Studies and Fluorescence Analysis
- Biochemical Analysis and Sensing Techniques
- Mitochondrial Function and Pathology
- Neurological Disease Mechanisms and Treatments
- Redox biology and oxidative stress
- Gut microbiota and health
- Analytical Chemistry and Chromatography
- Biochemical effects in animals
- Organoselenium and organotellurium chemistry
- Medicinal Plants and Bioactive Compounds
University of Coimbra
2013-2022
Centro de Neurociências e Biologia Celular
2017-2021
Laboratoire de Biochimie
2008
Institute of Pharmacology
2005
Universidade Federal de São Carlos
2003
Rede de Química e Tecnologia
1991-2003
Universidade de São Paulo
2003
Universidade Estadual Paulista (Unesp)
2003
Max Planck Institute for Biophysical Chemistry
1984
The potential use of polyphenols in the prevention and treatment chronic inflammatory diseases has been extensively investigated although mechanisms involved cellular signaling need to be further elucidated. Cyanidin-3-glucoside is a typical anthocyanin many pigmented fruits vegetables widespread human diet. In present study, protection afforded by cyanidin-3-glucoside against cytokine-triggered response was evaluated intestinal HT-29 cell line, comparison with 5-aminosalicylic acid,...
Luteolin efficiently fights intestinal inflammation. The inhibition of the JAK/STAT pathway by luteolin is a key mechanism.
Red wine polyphenols protect the intestinal barrier against inflammatory stimuli by modulating gene expression of key tight junction proteins.
Despite the actual therapeutic approaches for inflammatory bowel disease (IBD), efficient and secure alternative options remain a research focus. In this context, anthocyanins seem promising natural anti-inflammatory agents, but their action mechanisms efficacy as compared with established drugs still require more clarification. The main aim of study was to compare chemically characterized anthocyanin-rich fraction (ARF), obtained from Portuguese blueberries (Vaccinium corymbosum L.), that...
Oxidized low-density lipoproteins (ox-LDL) play a role in the genesis of atherosclerosis. OxLDL are able to induce apoptosis vascular cells, which is potentially involved formation necrotic center atherosclerotic lesions, plaque rupture, and subsequent thrombotic events. Because oxLDL may structural modifications cell protein altered proteins impair viability, present work aimed evaluate extent alterations, degradation modified through ubiquitin-proteasome system (a major degradative pathway...
Resveratrol (3,4',5-trihydroxystilbene) is a natural phytoalexin synthesized in response to injury or fungal attack, found the grape skin and wine, specially red wine. A large number of studies have demonstrated that resveratrol regulates many biological activities, namely protection against atherosclerosis by set pharmacological properties, including antioxidant activity. In this study, we explored capacity protecting low density lipoproteins (LDL) either ferrylmyoglobin-...
The development of new therapeutic approaches, combining efficacy and safety against intestinal inflammation, notably inflammatory bowel disease (IBD), has emerged as an important goal due to the significant side effects lack effectiveness standard current therapies. Recently, several studies described health-promoting red wine, including anti-inflammatory properties, but molecular mechanisms underlying its beneficial role remain largely unknown. Red wine is rich in phenolic compounds it...
Excess production of superoxide (O2−) and nitric oxide (NO) in blood vessel walls may occur early atherogenesis leading to the formation peroxynitrite, a strong oxidant nitrating agent. This study was designed determine effect diphenyl diselenide (PhSe)2, synthetic organoselenium compound, comparison with ebselen, on peroxynitrite-mediated endothelial damage. Experimental results showed that pre-incubation BAEC (24 h) low concentrations (PhSe)2 (0.5 1 μM) protected cells from...
Background Many advances have been recently made focused on the valuable help of dietary polyphenols in chronic inflammatory diseases. On other hand, current treatment options for intestinal bowel disease patients are unsatisfying and, this reason, it is estimated that many use supplements to achieve extra benefits. Aim The aim work was analyze under a mechanistic perspective anti-inflammatory potential resveratrol, natural polyphenolic compound, and compare with pharmaceutical agent,...