A5006711197- Pharmaceutical Practices and Patient Outcomes
- Medication Adherence and Compliance
- Blood Pressure and Hypertension Studies
- Epilepsy research and treatment
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical studies and practices
- Diabetes Management and Research
- Nitric Oxide and Endothelin Effects
- Pharmacological Effects and Toxicity Studies
- Public Health in Brazil
- Advanced Drug Delivery Systems
- Microbial metabolism and enzyme function
- Natural Antidiabetic Agents Studies
- Healthcare Regulation
- Analytical Methods in Pharmaceuticals
- Neuroscience and Neuropharmacology Research
- Pancreatic function and diabetes
- Inflammatory mediators and NSAID effects
- Patient Safety and Medication Errors
- Healthcare during COVID-19 Pandemic
- Diabetes and associated disorders
- Pharmacology and Obesity Treatment
- Diet and metabolism studies
University of Coimbra
2016-2025
Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão
2024
Universidade Estadual do Maranhão
2024
Association for Innovation and Biomedical Research on Light and Image
2015-2024
Faculdade Metropolitana de Manaus
2024
Centro de Neurociências e Biologia Celular
2017
Rede de Química e Tecnologia
2015
Universidade Estadual do Ceará
2012
Estácio (Brazil)
2012
Cooperativa de Ensino Superior Politécnico e Universitário
2007
The choice of appropriate animal models for the initial in vivo testing potential anticonvulsant compounds is one most important steps successful search new antiepileptic drugs. purpose this paper to describe aspects take into account when performing maximal electroshock seizure (MES) test routine laboratory screening antiepileptics: conventional and threshold MES experimental procedures, factors affecting data (laboratory conditions, administration vehicles drug formulations, time after...
Despite the actual therapeutic approaches for inflammatory bowel disease (IBD), efficient and secure alternative options remain a research focus. In this context, anthocyanins seem promising natural anti-inflammatory agents, but their action mechanisms efficacy as compared with established drugs still require more clarification. The main aim of study was to compare chemically characterized anthocyanin-rich fraction (ARF), obtained from Portuguese blueberries (Vaccinium corymbosum L.), that...
Cymbopogon citratus is one of the most common herbs used in folk medicine due to its anti-inflammatory and antioxidant properties.Taking into account these properties showed on vitro assays, aim this study was evaluate analgesic activities C. leaves infusion (CcE) flavonoid-rich (CcF) tannin-rich (CcT) fractions.The evaluation activity performed carrageenan-induced rat paw oedema model.Both central peripheral were evaluated mice through hot plate test acetic acid-induced writhing test,...
Agrimony ( Agrimonia eupatoria L.) (Ae) is used in traditional medicine to treat inflammatory and oxidative related diseases. Therefore, this study focuses on the anti‐inflammatory analgesic potential of Ae infusion (AeI). Phenolic compounds characterization was achieved by HPLC‐PDA‐ESI/MS n . To evaluate antioxidant potential, 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), superoxide anion, hydroxyl radical, SNAP assays were used. In vitro activity AeI investigated LPS‐stimulated macrophages...
Symptomatic control is essential in palliative care, particularly end-of-life, which the pathophysiological changes that characterize this last phase of life strengthen need to carry out an early therapeutic review. Hence, we aim evaluate prescribing pattern at a care unit two different time points: on admission and day patient's death.Quantitative, analytic, longitudinal, retrospective observational study. Participants were adult patients who admitted died unit, Portugal. Sociodemographic,...
Latex from Calotropis procera is widely used in folk medicine as a rich source of biologically active compounds capable promoting diverse benefits such control dermal fungal infections, antimicrobial activities and pain relief among other useful properties. The aim this work was to characterize the anti-inflammatory effect non-dialysable protein fraction recovered rubber-free latex using three different experimental models when administrated intravenously. In vivo neutrophil migration...
Breast cancer is one of the most common cancers worldwide, which makes it a very impactful malignancy in society. can be classified through different systems based on main tumor features and gene, protein, cell receptors expression, will determine advisable therapeutic course expected outcomes. Multiple options have already been proposed implemented for breast treatment. Nonetheless, their use efficacy still greatly depend classification, treatments are commonly associated with invasiveness,...
The global impact of cancer emphasizes the importance developing innovative, effective and minimally invasive therapies. In context superficial cancers, development a multifunctional nanoparticle-based system its in vitro vivo safety efficacy characterization are, herein, proposed as proof-of-concept. This consists gold nanoparticles coated with hyaluronic oleic acids, functionalized epidermal growth factor for greater specificity towards cutaneous melanoma cells. nanoparticle is activated...
A B S T R C TAmong the organisms used as biomonitors, oysters stand out due to large amounts of contaminants that accumulate in their tissues. The objective this research was determine physicochemical parameters estuarine system at three points São José Bay, Maranhão - Brazil, perform biometry oysters, and quantify nitrites (NO2-) intravalvular fluid oysters. brackish water showed dissolved oxygen presented values below levels recommended by Brazilian legislation. pH temperature remained...
Background: A correct selection of drugs prescribed, but also the choice appropriate inhaler device, is crucial for control respiratory diseases. Objective: To evaluate technique and identify potential errors patients when treated with inhalers by testing a routinary procedure to be implemented in any community pharmacy. Methods: Adults asthma/COPD under inhalation therapy were invited demonstrate how they use their inhalers. After direct observation it was registered whether all sequential...
Currently, insulin can only be administered through the subcutaneous route. Due to flaws associated with this route, it is of interest orally deliver drug. However, delivered has several barriers overcome as degraded by stomach's low pH, enzymatic content, and poor absorption in gastrointestinal tract. Polymers marine source like chitosan are commonly used nanotechnology drug delivery due their biocompatibility special features. This work focuses on preparation characterization mucoadhesive...
Subacute toxicological assessment on diabetic rats was conducted after 15 days of daily oral administration nanoparticulate insulin. Haematological and biochemical analyses were blood urine, biopsies performed organs tissues, histology analysed by optical microscopy. Insulin-loaded nanoparticles alone did not change liver or kidney functions. The increase some hepatic parameters attributed to diabetes physiopathology chemical inducement the nanoparticle composition since controls showed same...
Abstract Eslicarbazepine acetate (BIA 2‐093) is a novel central nervous system drug undergoing clinical phase III trials for epilepsy and II bipolar disorder. A simple reliable chiral reversed‐phase HPLC‐UV method was developed validated the simultaneous determination of eslicarbazepine acetate, oxcarbazepine, S‐ licarbazepine R ‐licarbazepine in human plasma. The analytes internal standard were extracted from plasma by solid‐phase extraction using Waters Oasis ® HLB cartridges....
Monoamine oxidase (MAO, type A and B) semicarbazide-sensitive amine (SSAO) metabolize biogenic amines, however, the impact of these enzymes in arteries from patients with 2 diabetes remains poorly understood. We investigated kinetic parameters to establish putative correlations noradrenaline (NA) content patient age human mesenteric diabetic patients. The were evaluated by radiochemical assay NA high-performance liquid chromatography (HPLC). activity MAO-A SSAO vascular tissues was...
Background: Using nanoparticles to improve non-steroidal anti-inflammatory drugs therapeutic profile is an interesting approach, especially concerning their gastric toxicity. Objective: The aim of this work was present a proof concept for nanoparticulate formulation composed biodegradable polymer poly (DL-lactic acid) (PLA) meant oral delivery ibuprofen (IBU) systemic circulation with reduced toxicity. Materials and methods: IBU-loaded PLA poloxamer 188 were prepared by...
Parvifloron D is a natural diterpene with broad and not selective cytotoxicity toward human tumor cells. In order to develop targeted antimelanoma drug delivery platform for D, hybrid nanoparticles were prepared biopolymers functionalized α-melanocyte stimulating hormone. Results/methodology: Nanoparticles produced according solvent displacement method the physicochemical properties assessed. It was shown that cytotoxic can induce, both as free encapsulated drug, cell death in melanoma cells...