A5032246906- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neuroscience and Neural Engineering
- Tryptophan and brain disorders
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Photoreceptor and optogenetics research
- Zebrafish Biomedical Research Applications
- Olfactory and Sensory Function Studies
- Receptor Mechanisms and Signaling
- Spaceflight effects on biology
- Neonatal Respiratory Health Research
- Wireless Body Area Networks
Centre National de la Recherche Scientifique
2021-2024
Inserm
2020-2024
Collège de France
2021-2024
Centre Interdisciplinaire de Recherche en Biologie
2016-2024
Université Paris Sciences et Lettres
2021-2024
Aix-Marseille Université
2023-2024
Institut de Neurosciences des Systèmes
2022-2024
Institut de Psychiatrie et Neurosciences de Paris
2016-2022
Université Paris Cité
2021-2022
Abstract While miniature inertial sensors offer a promising means for precisely detecting, quantifying and classifying animal behaviors, versatile sensing devices adapted small, freely-moving laboratory animals are still lacking. We developed standalone cost-effective platform performing high-rate wireless measurements of head movements in rats. Our system is designed to enable real-time bidirectional communication between the headborne device third party systems, which can be used precise...
Neuropixels probes have become a crucial tool for high-density electrophysiological recordings. Although most research involving these electrodes is in acute preparations, some scientific inquiries require long-term recordings freely moving animals. Recent reports presented prosthesis designs chronic recordings, but of them do not allow probe recovery, which desirable given their cost. Others appear to be fragile, as articles describe numerous broken implants. This fragility presents...
While there is substantial evidence that the dorsal and ventral hippocampus play different roles during emotional learning, it unknown how these are implemented whether neural populations in hippocampal regions express distinct activity profiles. To study this, we simultaneously recorded multiple single units structures fear conditioning. We found a predominance of responses related to expression hippocampus, which was unexpected considering extensive published supporting role regulating...
Neuropixels probes have become a crucial tool for high-density electrophysiological recordings. Although most research involving these is in acute preparations, some scientific inquiries require long-term recordings freely moving animals. Recent reports presented prosthesis designs chronic recordings, but of them do not allow probe recovery, which desirable given their cost. Others appear to be fragile, as articles describe numerous broken implants.Objective.This fragility presents challenge...
Cell assemblies, i.e., concurrently active groups of neurons, likely underlie neural processing for higher brain functions. Recent technological progress has enabled large-scale recording neuronal activity, permitting the exploration and analysis cell assembly dynamics. This review aims to provide both conceptual insights practical knowledge pertaining principal methodologies used detecting assemblies in last fifteen years. The goal is assist readers selecting comparing various protocols...
Cell assemblies are considered fundamental units of brain activity, underlying diverse functions ranging from perception to memory and decision-making. have generally been studied in relation specific stimuli or actions, but this approach does not readily extend more abstract constructs. An alternative is assess cell without making reference external variables, instead focus on internal processes — by defining their endogenous ability effectively elicit responses downstream (‘reader’)...
In-vivo longitudinal recordings require reliable means to automatically discriminate between distinct behavioral states, in particular awake and sleep epochs. The typical approach is use some measure of motor activity together with extracellular electrophysiological signals, namely the relative contribution theta delta frequency bands Local Field Potential (LFP). However, these can partially overlap oscillations characterizing other behaviors such as 4 Hz accompanying rodent freezing. Here,...
Introduction Dopamine release in the forebrain by midbrain ventral tegmental nucleus (VTA) and substantia nigra pars compacta (SNc) neurons is implicated reward processing, goal-directed learning, decision-making. Rhythmic oscillations of neural excitability underlie coordination network have been reported these dopaminergic nuclei at several frequency bands. This paper provides a comparative characterization frequencies local field potential single unit activity, highlighting some...
Abstract In the canonical interpretation of phasic activation dopaminergic neurons during Pavlovian conditioning, initially cell firing is triggered by unexpected rewards. Upon learning, instead follows reward-predictive conditioned stimulus. When expected rewards are withheld, inhibited. Here, we recorded optogenetically identified ventral tegmental area (VTA) in mice training successive operant sensory discrimination tasks. A delay was imposed between nose-poke choices and trial outcome...
Abstract Dopamine release in the forebrain by midbrain ventral tegmental nucleus (VTA) and substantia nigra pars compacta (SNpc) neurons is implicated reward processing, goal-directed learning, decision-making. Rhythmic oscillations of neural excitability underlie coordination network have been reported these dopaminergic nuclei at several frequency bands. This paper provides a comparative characterization frequencies local field potential single unit activity, highlighting some behavioral...
Current treatments for trauma-related disorders remain ineffective many patients. Here, we modeled interindividual differences in post-therapy fear relapse with a novel ethologically relevant trauma recovery paradigm. After traumatic conditioning, male rats underwent extinction while foraging large enriched arena, permitting the expression of wide spectrum behaviors, assessed by an automated pipeline. This multidimensional behavioral assessment revealed that post-conditioning response...