A5101503865- Neuroscience and Neuropharmacology Research
- Postharvest Quality and Shelf Life Management
- Ion channel regulation and function
- Plant Physiology and Cultivation Studies
- Polysaccharides and Plant Cell Walls
- Tryptophan and brain disorders
- Nuclear Receptors and Signaling
- Plant Surface Properties and Treatments
- Horticultural and Viticultural Research
- Neuroscience and Neural Engineering
- Epilepsy research and treatment
- Nicotinic Acetylcholine Receptors Study
- Pharmacological Receptor Mechanisms and Effects
- Treatment of Major Depression
- Plant Gene Expression Analysis
- Receptor Mechanisms and Signaling
- Parkinson's Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Photoreceptor and optogenetics research
- Phytochemicals and Antioxidant Activities
- Cardiac electrophysiology and arrhythmias
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Plant Disease Management Techniques
- Plant Stress Responses and Tolerance
Vanderbilt University Medical Center
2019-2024
Gansu Agricultural University
2023
Northwestern University
2011-2019
Northwest A&F University
2014-2018
Shandong Jiaotong Hospital
2015
Konkuk University Medical Center
2010
Konkuk University
2007
Rosalind Franklin University of Medicine and Science
2001
Abstract Fruit softening is mainly associated with cell wall structural modifications, and members of the xyloglucan endotransglucosylase/hydrolase (XTH) family are key enzymes involved in cleaving re-joining wall. In this work, we isolated a new XTH gene, DkXTH8 , from persimmon fruit. Transcriptional profiling revealed that peaked during dramatic fruit softening, expression was stimulated by propylene abscisic acid but suppressed gibberellic 1-MCP. Transient assays onion epidermal cells...
Ion channel trafficking and gating are often influenced by interactions with auxiliary subunits. Tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) is an subunit for neuronal hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. TRIP8b interacts directly two distinct sites of HCN pore-forming subunits to control gating. Here we use mutagenesis combined electrophysiological studies define distinguish the functional importance HCN/TRIP8b interaction sites....
Fruit cell wall modification is the primary factor affecting fruit softening. Xyloglucan endotransglycosylase/hydrolase (XTH), a wall-modifying enzyme, involved in In this study, two novel XTH genes (DkXTH6 and DkXTH7) were identified from persimmon fruit. Transcriptional profiles of both analyzed different tissues persimmon, response to multiple hormonal environmental treatments (gibberellic acid (GA3), abscisic (ABA), propylene, low temperature). Expression DkXTH6 was positively...
Temporal lobe epilepsy (TLE) is a prevalent neurological disorder with many patients experiencing poor seizure control existing anti-epileptic drugs. Thus, novel insights into the mechanisms of epileptogenesis and identification new drug targets can be transformative. Changes in ion channel function have been shown to play role generating aberrant neuronal activity observed TLE. Previous work demonstrates that hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate...
Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels function in the brain to limit neuronal excitability. Limiting activity of these has been proposed as a therapy for major depressive disorder, but critical role HCN cardiac pacemaking limited efforts develop therapies directed at channel. Previous studies indicated that is tightly regulated by its auxiliary subunit, tetratricopeptide repeat–containing Rab8b interacting protein (TRIP8b), which not expressed heart. To target...
Tetratricopeptide repeat (TPR) domains are ubiquitous structural motifs that mediate protein–protein interactions. For example, the TPR in peroxisomal import receptor PEX5 enable binding to a range of type 1 targeting signal motifs. A homolog PEX5, tetratricopeptide repeat–containing Rab8b-interacting protein (TRIP8b), binds and functions as an auxiliary subunit hyperpolarization-activated cyclic nucleotide (HCN)–gated channels. Given similarity between TRIP8b this difference function raises...