A5033796714- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Cholinesterase and Neurodegenerative Diseases
- Down syndrome and intellectual disability research
- Nicotinic Acetylcholine Receptors Study
- Congenital heart defects research
- Transgenic Plants and Applications
- Ion channel regulation and function
- Advanced Neuroimaging Techniques and Applications
- Biochemical Analysis and Sensing Techniques
- Signaling Pathways in Disease
- Memory and Neural Mechanisms
- Toxin Mechanisms and Immunotoxins
- Axon Guidance and Neuronal Signaling
Rush University Medical Center
2018-2024
University of Wisconsin–Madison
2024
University of Georgia
2020
United States Department of Energy
2020
Office of Science
2020
Rush University
2019
Salisbury University
2012-2017
Loyola University Chicago
2016
Significance A longstanding question in the field of neurobiology learning and memory is why some aged individuals perform comparably to young adults tasks, whereas others show impairments that resemble performance those with hippocampal damage. Answers this have been critical for advancing our understanding of, ability treat, aging-related cognitive impairments. Here, we exploited exquisite organization circuit reveal “unsuccessful” aging associated a breakdown adult-like organization,...
The innervation of taste buds is an excellent model system for studying the guidance axons during targeting because their discrete nature and high fidelity innervation. pregustatory epithelium fungiform papillae known to secrete diffusible axon cues such as BDNF Sema3A that attract repel, respectively, geniculate ganglion targeting, but factors alone are unlikely explain how terminals restricted territories within bud. Nondiffusible cell surface proteins Ephs ephrins can act receptors and/or...
Reactive oxygen species (ROS) produced in living organisms can generate oxidative stress, which contributes to cell damage associated with neurodegenerative diseases, such as Alzheimer's and Parkinson's. Studying responses stress model organisms, like the nematode worm Caenorhabditis elegans , may provide insight into basic underlying cellular mechanisms shared humans. MRCK‐1 (myotonic dystrophy kinase‐related Cdc42 binding kinase), a highly conserved intracellular kinase, is activated by...
MRCK‐1 (myotonic dystrophy kinase‐related Cdc42 binding kinase) acts downstream of the Rho GTPase CDC‐42 to determine cell polarity and is critical for C. elegans embryonic development. Given conserved GXXXXCGKTC redox‐sensitive motif in phosphoryl‐binding loop CDC‐42, a role cellular responses reactive oxygen species (ROS) being explored. An RNA interference (RNAi) construct 190 bp targeting exon 5 mrck‐1 gene on chromosome V was cloned into RNAi expression vector pL4440 enable production...
Alzheimer's disease (AD) is marked by the accumulation of Amyloid beta peptides, neuronal cell death, and synapse loss. However, dysregulation voltage gated ion channels may also contribute to AD progression. Our lab has shown that in dorsal hippocampus transgenic mouse models AD, CA1 pyramidal neurons exhibit a channelopathy which hyperpolarization-activated cyclic-nucleotide (HCN) are mislocalized. magnetic resonance imaging (MRI) studies have anterior hippocampus, corresponding ventral...
Alzheimer's disease (AD) is known to involve substantial synapse loss and cell death, especially during later stages. While these consistently observed changes occur in the grey matter (GM), diffusion-tensor imaging (DTI) studies have shown that AD patients also exhibit white (WM). However, little work has been done understand cellular basis of observations. It posited WM are merely caused by Wallerian degeneration, but more recent not supported this conclusion. A likely alternative...
Caldicellulosiruptor has the ability to digest complex plant biomass without pretreatment and have been engineered convert biomass, a sustainable, carbon neutral substrate, fuels. Their strategy for deconstructing cell walls relies on an interesting class of cellulases consisting multiple catalytic modules connected by linker regions carbohydrate binding modules. The best studied these enzymes, CelA, unique deconstruction mechanism. CelA is located in cluster genes that likely allows optimal...