A5028882117- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Mycology
- Antibiotic Use and Resistance
- HIV/AIDS oral health manifestations
- Plant Pathogens and Fungal Diseases
- Neutropenia and Cancer Infections
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Infections and bacterial resistance
- Tuberculosis Research and Epidemiology
- COVID-19 Clinical Research Studies
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- HIV Research and Treatment
- Drug-Induced Adverse Reactions
- Streptococcal Infections and Treatments
- HIV/AIDS drug development and treatment
- Social Media in Health Education
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Mycobacterium research and diagnosis
Washington University in St. Louis
2016-2025
Association Clinique et Thérapeutique Infantile du Val de Marne
2023-2024
Office of Infectious Diseases
2019
Jewish Hospital
2018
Barnes-Jewish Hospital
2016-2018
Rush University Medical Center
2011-2016
Loyola University Chicago
2005-2016
University of Illinois Chicago
2009
Abstract Background The dimorphic mycoses (DMs) of the United States—Histoplasma, Coccidioides, and Blastomyces—commonly known as endemic North America (in addition to Paracoccidioides) are increasingly being diagnosed outside their historical areas endemicity. Despite this trend, maps outlining geographic distributions have not been updated in more than half a century using large, nationwide database containing individual-patient–level data. Methods This was retrospective analysis...
Despite appropriate therapy, Candida bloodstream infections are associated with a mortality rate of approximately 40%. In animal models, impaired immunity due to T cell exhaustion has been implicated in fungal sepsis mortality. The purpose this study was determine potential mechanisms fungal-induced immunosuppression via immunophenotyping circulating lymphocytes from patients microbiologically documented infections.Patients blood cultures positive for any species were studied. Non-septic...
In this population-based study in the contemporary era United States, proportion of human immunodeficiency virus (HIV)-negative patients with cryptococcosis approaches that HIV-infected patients. Cryptococcosis is associated higher mortality rates HIV-negative (including organ transplant recipients).
Coronavirus disease 2019 (COVID-19) can become complicated by secondary invasive fungal infections (IFIs), stemming primarily from severe lung damage and immunologic deficits associated with the virus or immunomodulatory therapy. Other risk factors include poorly controlled diabetes, structural and/or other comorbidities, colonization. Opportunistic IFI following respiratory viral illness has been increasingly recognized, most notably influenza. There have many reports of COVID-19, initially...
Cryptococcosis is increasingly recognized in people without human immunodeficiency virus (HIV).A multicenter, prospective cohort study was performed 25 US centers. Consenting patients were prospectively followed for ≤2 years. Neurological morbidities assessed with longitudinal event depiction and functional scores (Montreal Cognitive Assessment [MoCA]). Risks of death analyzed using Cox regression.One hundred forty-five subjects enrolled. Most male (95; 65.5%) had immunosuppression (120;...
To evaluate the safety and efficacy of two dosing regimens oral ibrexafungerp (formerly SCY-078), a novel orally bioavailable β-glucan synthase inhibitor, in subjects with invasive candidiasis versus standard care (SOC) to identify dose achieve target exposure (15.4 μM·h) >80% intended population.In multinational, open-label study, patients documented were randomized receive step-down therapy one three treatment arms: or SOC following initial echinocandin therapy. Plasma samples collected by...
Background. The epidemic of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has had a disproportionate impact on patients with human immunodeficiency virus (HIV). Methods. We evaluated CA-MRSA colonization burden (number colonized sites per total number sampled) among HIV-infected and HIV-negative inpatients within 72 hours hospitalization. From March 2011 through April 2012, we obtained cultures from nasal extranasal (throat, axilla, inguinal, perirectal, chronic...
Abstract Background This study quantifies the mortality attributable to Candida bloodstream infections (BSI) in modern era of echinocandins. Methods We conducted a retrospective cohort adult patients admitted Barnes Jewish Hospital, 1368-bed tertiary care academic hospital, Saint Louis, Missouri, from 1 February 2012 30 April 2019. identified 626 with BSI that were frequency-matched 6269 control had similar risk-factors. The 90-day all-cause was calculated using three methods—propensity...
Abstract Invasive fungal infections continue to increase as at-risk populations expand. The high associated morbidity and mortality with diseases mandate the continued investigation of novel antifungal agents diagnostic strategies that include surrogate biomarkers. Biologic markers disease are useful prognostic indicators during clinical care, their use in place traditional survival end points may allow for more rapid conduct trials requiring fewer participants, decreased trial expense,...
Abstract Background Histoplasmosis is a major AIDS-defining illness in Latin America. Liposomal amphotericin B (L-AmB) the drug of choice for treatment, but access restricted due to high and hospitalization costs conventional long regimens. Methods Prospective randomized multicenter open-label trial 1- or 2-dose induction therapy with L-AmB versus control disseminated histoplasmosis AIDS, followed by oral itraconazole therapy. We subjects to: (i) single dose 10 mg/kg L-AmB; (ii) on D1, 5 D3;...
Abstract Coccidioidomycosis, histoplasmosis, and blastomycosis are underrecognized frequently misdiagnosed fungal infections that can clinically resemble bacterial viral community-acquired pneumonia. This guidance is intended to help outpatient clinicians test for these diseases in patients with pneumonia reduce misdiagnoses, unnecessary antibacterial use, poor outcomes.
Abstract Background Invasive fungal disease caused by dimorphic fungi is associated with significant morbidity and mortality. Super-bioavailability itraconazole (SUBA-itra) a novel antifungal agent pharmacokinetic advantages over currently available formulations. In this prospective comparative study, we report the outcomes of patients endemic infections (histoplasmosis, blastomycosis, coccidioidomycosis, sporotrichosis). Methods This open-label randomized trial evaluated efficacy, safety,...