A5033407848- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Bacterial Identification and Susceptibility Testing
- Infectious Diseases and Mycology
- Antibiotic Resistance in Bacteria
- Cardiac Valve Diseases and Treatments
- Antibiotic Use and Resistance
- Neutropenia and Cancer Infections
- Iron Metabolism and Disorders
- Infective Endocarditis Diagnosis and Management
- Parasitic Infections and Diagnostics
- Hemoglobinopathies and Related Disorders
- Streptococcal Infections and Treatments
- Bladder and Urothelial Cancer Treatments
- Plant Pathogens and Fungal Diseases
- Neuroscience and Neural Engineering
- Healthcare cost, quality, practices
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmacological Effects and Toxicity Studies
- Urinary Tract Infections Management
- Memory and Neural Mechanisms
- Bipolar Disorder and Treatment
- Neuroscience and Neuropharmacology Research
- Clostridium difficile and Clostridium perfringens research
- Patient Satisfaction in Healthcare
University of Arizona
2020-2024
Banner - University Medical Center Tucson
2022-2024
University of Alabama at Birmingham
2017-2019
Pediatrics and Genetics
2019
Louisiana State University Health Sciences Center New Orleans
2009
Queen Elizabeth II Hospital
2000
University of Hertfordshire
2000
Abstract Background Invasive fungal disease caused by dimorphic fungi is associated with significant morbidity and mortality. Super-bioavailability itraconazole (SUBA-itra) a novel antifungal agent pharmacokinetic advantages over currently available formulations. In this prospective comparative study, we report the outcomes of patients endemic infections (histoplasmosis, blastomycosis, coccidioidomycosis, sporotrichosis). Methods This open-label randomized trial evaluated efficacy, safety,...
Abstract Coccidioidomycosis poses a significant cost and morbidity burden in the United States. Additionally, coccidioidomycosis requires constant decision-making related to prevention, diagnosis, management. Delays diagnosis lead consequences, including unnecessary diagnostic workup antibacterial therapy. Antifungal stewardship considerations regarding empiric, prophylactic, targeted management of are also complex. In this review, problems facing antimicrobial programs (ASPs) endemic region...
Abstract Objective: This study aimed to examine the clinical risk factors for cephalosporin resistance in patients with Gram-negative bacteremia caused by Escherichia coli (EC), Klebsiella pneumoniae (KP), Enterobacter cloacae (ENC), and Pseudomonas aeruginosa (PS). Methods: retrospective cohort included 400 adults bacteremia. The goal was review 100 cases involving each species approximately half resistant susceptible first-line cephalosporins, ceftriaxone (EC or KP), cefepime (ENC PS)....
Abstract Background C-ITC is a drug of choice for non-life-threatening, non-CNS histoplasmosis, blastomycosis, sporotrichosis, coccidioidomycosis and other EM. Oral problematic due to inconsistent absorption often leading sub-therapeutic serum levels. SUBA-ITC an FDA approved formulation which utilizes nanotechnology provide more consistent when compared C-ITC. We performed open-label RCT comparing non-life-threatening EM, the first US based examining SUBA-ITC. Herein we report PK during 6...
Candidemia is a common hospital-acquired infection that associated with high mortality. Diagnosis via blood cultures (BC) limited by poor sensitivity (50%) and slow turnaround time (2–5 days). T2Candida (T2C) newly available rapid test using magnetic resonance can detect 5 species of Candida from whole in < 6 hours 91.1%. We performed retrospective analysis all cases candidemia detected BC and/or T2C during 2016 at UAB Medical Center. The was targeted to ICU patients who had higher risk...
Antimicrobial stewardship has traditionally focused on the optimal use of antibacterial agents. Much less attention is antifungal therapy (AFT). The high mortality and emergence resistance in invasive infections due to Candida presents a critical opportunity for AFT stewardship. T2Candida (T2C) panel rapid diagnostic test using magnetic resonance detect 5 different species whole blood. T2C sensitivity 91%, specificity 99%, negative predictive value generates results <6 hours. We conducted...
Clostridium difficile infection (CDI) Laboratory identified events are reportable to CMS through the CDC's NHSN. Diagnostic stewardship has been shown decrease incidence by decreasing false-positive incidence. Bowel management systems (BMS) have associated with transient loss of tone anal sphincter muscles that result in diarrhea. These episodes diarrhea may be misdiagnosed as CDI due a test result. The objective this study was determine whether use BMS resulted Lab ID events. We performed...
Abstract Background Fluconazole (fluc) is a common antifungal used at hospitals and an important target for antimicrobial stewardship (AS). Fluc also management of coccidioidomycosis (C). The objective our study was to describe fluc prescribing patterns two academic centers in Arizona. Methods We conducted retrospective analysis usage adult patients. One month from each quarter one-year period (November 2017-November 2018) selected (4 months total). All patients that received Hospital A B...
Background: Stroke is one of the most devastating complications sickle cell anemia (SCA). The STOP (Stroke Prevention Trial in Sickle Cell Anemia) protocol was adopted 2014 by National Heart Lung and Blood Institute (NHLBI) guidelines for stroke‐risk screening using transcranial Doppler ultrasound (TCD) prevention with chronic red transfusion therapy (CRCT) 1 . Despite high‐level evidence supporting use TCD (and CRCT initiation) stroke 2,3 , wide scale implementation has not been achieved 4...