A5080922855- Neuroscience and Neuropharmacology Research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Genetics and Neurodevelopmental Disorders
- Peroxisome Proliferator-Activated Receptors
- Amino Acid Enzymes and Metabolism
- Epilepsy research and treatment
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Circadian rhythm and melatonin
- Mitochondrial Function and Pathology
- Genomics and Chromatin Dynamics
- Congenital heart defects research
Polish Academy of Sciences
2017-2025
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2017-2025
Institute of Experimental Physics of the Slovak Academy of Sciences
2023
Abstract Epilepsy frequently develops as a result of brain insult; however, there are no tools allowing to predict which patients suffering from trauma will eventually develop epilepsy. microRNAs interesting candidates for biomarkers, several them have been described change their levels in the brains, and plasma epileptic subjects. This study was conducted evaluate usefulness miRNAs epileptogenesis/epilepsy biomarkers. In our studies, we used rat model temporal lobe An epileptogenic insult...
VPS10P domain receptors emerge as central regulators of intracellular protein sorting in neurons with relevance for various brain pathologies. Here, we identified a role the family member SorCS2 protection from oxidative stress and epilepsy-induced cell death. We show that acts receptor sustains surface expression neuronal amino acid transporter EAAT3 to facilitate import cysteine, required synthesis reactive oxygen species scavenger glutathione. Lack causes depletion plasma membrane impairs...
The present study performed a detailed analysis of behavior in rat model epilepsy using both established and novel methodologies to identify behavioral impairments that may differentiate between animals with short versus long latency spontaneous seizures low high number seizures. Temporal lobe was induced by electrical stimulation the amygdala. Rats were stimulated for 25 min 100-ms trains 1-ms biphasic square-wave pluses delivered every 0.5 s. Electroencephalographic recordings classify...
Abstract Epilepsy frequently develops as a result of brain insult, for example, injury or stroke. Currently, there are no tools allowing us to predict which trauma patients will eventually develop epilepsy. There is evidence that microRNAs levels altered in the blood, making them attractive candidates peripheral biomarkers We analyzed white blood cell subpopulations containing miR-155-5p and miR-674-3p, control stimulated animals symptomatic asymptomatic amygdala stimulation model. The first...
Abstract Our previous in silico data indicated an overrepresentation of the ZF5 motif promoters genes which circadian oscillations are altered ventral hippocampus pilocarpine model temporal lobe epilepsy mice. In this study, we test hypothesis that Zbtb14 protein oscillates a manner and oscillation is disrupted by epilepsy. We found immunostaining present cytoplasm cell nuclei. Western blot indicate cytoplasmic nuclear levels oscillate, but phase shifted. The densities Zbtb14-immunopositive...
Abstract Background Epilepsy frequently develops as a result of brain insult, e.g., injury or stroke; however, currently, there are no tools allowing us to predict which patients suffering from trauma will eventually develop epilepsy. microRNAs interesting candidates for biomarkers, several them have been described change their levels in the brains epileptic subjects. There is evidence suggesting that microRNA also altered plasma during This study was conducted evaluate usefulness miRNAs...
Abstract Methyl CpG binding domain 3 (Mbd3) protein belongs to the MBD family of proteins and is responsible for reading DNA methylation pattern. Our previous study showed increased levels NuRD complex proteins, including Mbd3 protein, in brains epileptic animals. The present investigated whether determines seizure threshold. An increase was demonstrated entorhinal cortex/amygdala rat’s brain 4 hours after pentylenetetrazole (PTZ)-induced seizures. Reduction level using shRNA coding AAV...
SUMMARY The family of VPS10P domain receptors emerges as central regulator intracellular protein sorting in neurons with relevance for various brain pathologies. Here, we identified a unique role the member SorCS2 protection from oxidative stress and epilepsy-induced cell death. We show that acts receptor targets neuronal amino acid transporter EAAT3 to plasma membrane facilitate import cysteine, required synthesis reactive oxygen species scavenger glutathione. Absence activity causes...
Abstract Tweety-homolog 1 protein ( Ttyh1 ) is abundantly expressed in neurons the healthy brain, and its expression induced under pathological conditions. In hippocampal vitro, was implicated regulation of primary neuron morphology. However, mechanisms that underlie transcriptional gene remain elusive. The present study sought to identify promoter functionally characterize cis -regulatory elements are potentially involved rat dissociated vitro. We cloned a 592 bp sequence designed deletion...