A5033788578- Psychosomatic Disorders and Their Treatments
- Obsessive-Compulsive Spectrum Disorders
- Mitochondrial Function and Pathology
- Visual perception and processing mechanisms
- Genetic Neurodegenerative Diseases
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Optical Imaging and Spectroscopy Techniques
- Transcranial Magnetic Stimulation Studies
- Pain Management and Placebo Effect
- Color perception and design
- Motor Control and Adaptation
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Spatial Neglect and Hemispheric Dysfunction
- Gaze Tracking and Assistive Technology
- Neurological and metabolic disorders
- Neurological disorders and treatments
- Action Observation and Synchronization
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
University of Pennsylvania
2024-2025
National Institute of Neurological Disorders and Stroke
2019-2022
National Institutes of Health
2019-2022
New York University
2019-2020
Aberrant interoceptive processing has been hypothesized to contribute the pathophysiology of functional neurological disorder, although findings have inconsistent. Here, we utilized magnetic resonance imaging (fMRI) examine neural correlates attention - conscious focus and awareness bodily sensations in movement disorder (FMD). We used voxelwise analyses compare blood oxygenation level-dependent responses between 13 adults with hyperkinetic FMD healthy controls (HCs) during a task requiring...
Humans have a distinguishing ability for fine motor control that is subserved by highly evolved cortico-motor neuronal network. The acquisition of particular skill involves long series practice movements, trial and error, adjustment refinement. At the cortical level, this begins in parieto-temporal sensory regions subsequently consolidated stratified premotor-motor cortex. Task-specific dystonia can be viewed as corruption or loss confined to single skill. Using multimodal experimental...
Neuroimaging studies suggest that corticolimbic dysfunctions, including increased amygdala reactivity to emotional stimuli and heightened fronto-amygdala coupling, play a central role in the pathophysiology of functional movement disorders (FMD). Transcranial magnetic stimulation (TMS) has potential probe modulate brain networks implicated neuropsychiatric disorders, FMD. Therefore, objective this proof-of-concept study was investigate safety, tolerability preliminary efficacy...
Abstract Pupil size is an easily accessible, noninvasive online indicator of various perceptual and cognitive processes. measurements have the potential to reveal continuous processing dynamics throughout experimental trial, including anticipatory responses. However, relatively sluggish (∼2 s) response pupil dilation make it challenging connect changes in events occurring close together time. Researchers used models link specific trial events, but such methods not been systematically...
Functional movement disorder (FMD) is a type of functional neurological characterized by abnormal movements that patients do not perceive as self-generated. Prior imaging studies show complex pattern altered activity, linking regions the brain involved in emotional responses, motor control, and agency. This study aimed to better characterize these relationships building classifier using support vector machine accurately distinguish between 61 FMD 59 healthy controls features derived from...
Spinocerebellar Ataxia type 7 (SCA7) is a neurodegenerative disease characterized by progressive cerebellar ataxia and retinal degeneration. Increasing loss of visual function complicates the use clinical scales to track progression motor symptoms, hampering our ability develop accurate biomarkers progression, thus test efficacy potential treatments. We aimed identify imaging measures neurodegeneration, which may more accurately reflect SCA7 severity progression. While common structural MRI...
Abstract Background Aberrant interoceptive processing has been hypothesized to contribute the pathophysiology of functional neurological disorder, although findings have inconsistent. Here, we utilized magnetic resonance imaging (fMRI) examine neural correlates attention – conscious focus and awareness bodily sensations in movement disorder (FMD). Methods We used voxelwise analyses compare blood oxygenation level-dependent responses between 13 adults with hyperkinetic FMD healthy controls...
Goal: Pupil size is an easily accessible, noninvasive online indicator of various cognitive processes. measurements can reveal continuous processing dynamics throughout experimental trial, including anticipatory responses. However, the relatively sluggish (~1 s) response pupil dilation makes it challenging to connect changes in events occurring close together time. Researchers have begun use models link specific trial events, but such methods not been systematically evaluated. Here we...
May 5, 2019April 9, 2019Free AccessStructural Magnetic Resonance Imaging Correlates of Neurodegeneration in a Spinocerebellar Ataxia Type 7 Cohort (P1.8-009)Jacob Parker, Silvina Horovitz, Sanaz Attaripour, Shabbir Hussain Merchant, Patrick McGurrin, and Mark HallettAuthors Info & AffiliationsApril 2019 issue92 (15_supplement)https://doi.org/10.1212/WNL.92.15_supplement.P1.8-009 Letters to the Editor
Abstract Spinocerebellar Ataxia type 7 (SCA7) is a neurodegenerative disease characterized by progressive cerebellar ataxia and retinal degeneration. Increasing loss of visual function complicates the use clinical scales to track progression motor symptoms, hampering our ability develop accurate biomarkers progression, thus test efficacy potential treatments. In this cross-sectional study, we aimed identify imaging measures neurodegeneration, which may more accurately reflect SCA7 severity...
Abstract Background Neuroimaging studies suggest that corticolimbic dysfunctions, including increased amygdala reactivity to emotional stimuli and heightened fronto-amygdala coupling, play a central role in the pathophysiology of functional movement disorders (FMD), although there is no direct causal evidence this relationship. Transcranial magnetic stimulation (TMS) has potential probe modulate brain networks implicated neuropsychiatric disorders, FMD. Therefore, proof-of-concept study, we...
Abstract Functional movement disorder (FMD) is a type of functional neurological characterized by abnormal movements that patients do not recognize as self-generated. Prior imaging studies show complex pattern altered activity, linking regions the brain involved in emotional responses, motor control, and agency. This study aimed to better characterize these relationships building classifier via support vector machine (SVM) accurately classify 61 FMD from 59 healthy controls using features...