A5070246671- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Multiple Sclerosis Research Studies
- Muscle activation and electromyography studies
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Motor Control and Adaptation
- Genetic Neurodegenerative Diseases
- Vestibular and auditory disorders
- Neuroscience and Neural Engineering
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Peripheral Neuropathies and Disorders
- Neural and Behavioral Psychology Studies
- Hereditary Neurological Disorders
- Long-Term Effects of COVID-19
- Autoimmune and Inflammatory Disorders Research
- Epilepsy research and treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cerebral Palsy and Movement Disorders
- Effects of Vibration on Health
- Hallucinations in medical conditions
- Neurosurgical Procedures and Complications
Istituto Neurologico Mediterraneo
2018-2025
Sapienza University of Rome
2016-2025
Istituto Superiore di Sanità
2024
Fondazione Santa Lucia
2024
Zero to Three
2024
National Institutes of Health
2017-2024
Hudson Institute
2023
National Institute of Neurological Disorders and Stroke
2017-2022
Freezing of gait (FOG) is a leading cause falls and fractures in Parkinson's disease (PD). The episodic rather unpredictable occurrence FOG, coupled with the variable response to L-Dopa this disorder, makes objective evaluation FOG severity major clinical challenge therapeutic management patients PD. aim study was examine compare gait, clinically objectively, PD, without by means new wearable system. We also assessed effect on specific spatio-temporal parameters FOG. To purpose, we recruited...
Motor impairment in Parkinson's disease (PD) reflects changes the basal ganglia-thalamocortical circuit converging on primary motor cortex (M1) and supplementary area (SMA). Previous studies assessed M1 excitability PD using transcranial magnetic stimulation (TMS)-evoked electromyographic activity. TMS-evoked electroencephalographic activity may unveil broader cortical network PD.The aim was to assess PD.We compared potentials (TEPs) from pre-SMA between 20 patients tested off medication 19...
Abstract Background Parkinson's disease patients may show a tremor that appears after variable delay while the arms are kept outstretched (re‐emergent tremor). The objectives of this study were to investigate re‐emergent pathophysiology by studying role primary motor cortex in and making comparison with rest tremor. Methods We enrolled 10 both Tremor was assessed spectral analysis, corticomuscular coherence tremor‐resetting produced transcranial magnetic stimulation over cortex. also...
To investigate molecular biomarkers of a-synuclein and tau aggregation, autophagy, inflammation in the saliva de novo Parkinson's disease (PD) patients comparison to healthy subjects (HS), correlate data with clinical features PD patients, order establish whether abnormalities these parameters are associated specific clusters their potential diagnostic power differentiating from HS.We measured total oligomeric a-synuclein, total-tau phosphorylated-tau, microtubule-associated protein light...
Motor fatigue is one of the most common symptoms in multiple sclerosis (MS) patients. Previous studies suggested that increased motor MS may arise at central nervous system level. However, mechanisms underlying are still unclear. This paper investigated whether reflects impaired corticospinal transmission or suboptimal primary cortex (M1) output (supraspinal fatigue). Furthermore, we sought to identify associated with abnormal M1 excitability and connectivity within sensorimotor network....
Short-latency intracortical inhibition (SICI) and motor surround (mSI) are cortical phenomena that have been investigated with transcranial magnetic stimulation (TMS). mSI is believed to be necessary for the execution of fine finger movements, SICI may participate in genesis, however, mechanisms underlying both not entirely clear.We explored physiology healthy subjects by TMS-evoked potentials (TEPs).Single (sp) paired-pulse (pp) TMS were delivered on ADM muscle hotspot while recording EEG...
Humans have a distinguishing ability for fine motor control that is subserved by highly evolved cortico-motor neuronal network. The acquisition of particular skill involves long series practice movements, trial and error, adjustment refinement. At the cortical level, this begins in parieto-temporal sensory regions subsequently consolidated stratified premotor-motor cortex. Task-specific dystonia can be viewed as corruption or loss confined to single skill. Using multimodal experimental...
Studies using transcranial magnetic stimulation (TMS) have demonstrated the importance of direction and intensity applied current when primary motor cortex (M1) is targeted. By varying these, it possible to stimulate different subsets neural elements, as by modulation evoked potentials (MEPs) behaviour. The latter involves premotor areas well, among them, presupplementary area (pre–SMA) has recently received significant attention in study inhibition. It that, similar M1, neuronal populations...