A5064929789- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Advanced Sensor and Energy Harvesting Materials
- Epigenetics and DNA Methylation
- Cholinesterase and Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Respiratory viral infections research
- Psychosomatic Disorders and Their Treatments
- Genetic Syndromes and Imprinting
- Protein Degradation and Inhibitors
- Advances in Oncology and Radiotherapy
- Congenital Heart Disease Studies
- Tumors and Oncological Cases
- Ion channel regulation and function
- Genomic variations and chromosomal abnormalities
- Mental Health and Psychiatry
- Congenital heart defects research
- Advanced Memory and Neural Computing
- Influenza Virus Research Studies
- Hemoglobinopathies and Related Disorders
- Frailty in Older Adults
- Health Sciences Research and Education
- Innovations in Medical Education
- Neurogenetic and Muscular Disorders Research
Sapienza University of Rome
2018-2025
Istituto Neurologico Mediterraneo
2024-2025
Community Options (United States)
2023
Columbia University Irving Medical Center
2018
Columbia University
2017
After the recent limitations to prescribing valproate, many studies have highlighted challenging management of female patients reproductive age with idiopathic generalized epilepsy (IGE). However, no study, authors' knowledge, has addressed comparative effectiveness alternative antiseizure medications (ASMs) in these patients.
Abstract Objective Due to the high clinical heterogeneity of epilepsy, there is a critical need for novel metrics aimed at capturing its biological and phenotypic complexity. Frailty increasingly recognized in various medical disciplines as useful construct understand differences susceptibility adverse outcomes. Here, we develop frailty index (FI) patients with epilepsy (PwE) explore association demographic features. Methods In this cross‐sectional study, consecutively enrolled 153 PwE from...
Importance Women with idiopathic generalized epilepsy (IGE) face challenges in treatment due to limited options that are both effective and safe. Objective To evaluate the effectiveness safety of substitution monotherapy vs add-on therapy as second-line for women who might become pregnant IGE after failure first-line antiseizure medications (ASMs) other than valproic acid. Design, Setting, Participants Multicenter retrospective comparative cohort study at 18 primary, secondary, tertiary...
This real-world, retrospective, multicenter study aims to investigate the effectiveness of highly purified cannabidiol (CBD) in a large cohort patients with epilepsy genetic etiology due an identified monogenic cause. Additionally, we examine potential relationship between specific subgroups and treatment response. was conducted across 27 centers included epileptic disorders (pathogenic or likely pathogenic variants) who were treated CBD for at least 3 months. A total 266 (135 females,...
Parkinson's disease (PD) is a neurodegenerative disorder associated with widespread aggregation of α-synuclein and dopaminergic neuronal loss in the substantia nigra pars compacta. As result, striatal denervation leads to functional changes cortico-basal-ganglia-thalamo-cortical loop, which turn cause most parkinsonian signs symptoms. Despite tremendous advances field last two decades, overall management (i.e., diagnosis follow-up) patients PD remains largely based on clinical procedures....
Juvenile myoclonic epilepsy is an idiopathic generalized syndrome associated with photosensitivity in approximately 30-40% of cases. Microstates consist a brief period time during which the topography whole resting-state electroencephalography signal characterized by specific configuration. Previous neurophysiological and neuroimaging studies have suggested that Microstate B may represent activity within visual network. In this case-control study, we aimed to investigate whether anatomical...
Abstract Objective Lennox–Gastaut syndrome (LGS) is a severe form of epilepsy characterized by difficult‐to‐control seizures and cognitive dysfunction. Previous studies mainly focused on pediatric populations, little known about the long‐term outcome in adult patients with LGS. The objective this study was to investigate functional adaptive behavior Methods This cross‐sectional enrolled diagnosed LGS according recently published International League Against Epilepsy (ILAE) diagnostic...
Soluble forms of oligomeric beta-amyloid (Aβ) are thought to play a central role in Alzheimer's disease (AD). Transgenic manipulation methylation the serine/threonine protein phosphatase, PP2A, was recently shown alter sensitivity mice AD-related impairments resulting from acute exposure elevated levels Aβ. In addition, eicosanoyl-5-hydroxytryptamide (EHT), naturally occurring component coffee beans that modulates PP2A methylation, confer therapeutic benefits rodent models AD and Parkinson's...
Vaccine coverage of health care professionals against influenza is still low in Italy, as well other European countries.Between March and May 2018, this study was performed to collect the opinions Pediatric professionals, working emergency departments, regarding efficacy safety vaccine. An anonymous online survey employed evaluate socio-demographic professional characteristics, knowledges, beliefs attitudes.Five hundred four completed survey: 331 physicians, 140 nurses 33 are professionals....
Abstract Objective This study was undertaken to characterize the clinical and genetic features of patients with 22q11.2 deletion syndrome (22q11.2DS) generalized epilepsy compared 22q11.2DS individuals without epilepsy. Methods multicenter case–control included 28 22q11.2DS‐related their data 56 age‐matched controls Clinical electroencephalographic features, neuropsychiatric systemic comorbidities, family history epilepsy, findings were collected. Results Generalized tonic–clonic seizures...
<h3>Objectives</h3> Medical schools worldwide have increasingly included EBM principles in undergraduate curriculum either different courses or one specific course. In Italy complete and systematic data on teaching medical are lacking. Indirect information comes from a survey conducted by GIMBE Foundation more than 600 students who applied for scholarship to acquire Evidence-based Practice core curriculum. Most of respondents outlined that is mainly taught occasional lectures seminars,...