Roberto De Simone

ORCID: 0000-0002-0954-8668
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About
Contact & Profiles
Research Areas
  • Migraine and Headache Studies
  • Cerebral Venous Sinus Thrombosis
  • Trigeminal Neuralgia and Treatments
  • Neurosurgical Procedures and Complications
  • Sympathectomy and Hyperhidrosis Treatments
  • Ophthalmology and Eye Disorders
  • Epilepsy research and treatment
  • Psychosomatic Disorders and Their Treatments
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Cardiovascular Syncope and Autonomic Disorders
  • Glaucoma and retinal disorders
  • Cerebrospinal fluid and hydrocephalus
  • Pharmacological Effects and Toxicity Studies
  • Ocular Diseases and Behçet’s Syndrome
  • Neurological Complications and Syndromes
  • Botulinum Toxin and Related Neurological Disorders
  • Sinusitis and nasal conditions
  • Vestibular and auditory disorders
  • Legal and Labor Studies
  • Acute Ischemic Stroke Management
  • Cardiovascular Function and Risk Factors
  • Neuroscience of respiration and sleep
  • Diverse academic and cultural studies
  • Italian Literature and Culture
  • Historical and Environmental Studies

Federico II University Hospital
2011-2024

University of Naples Federico II
2014-2024

Community Options (United States)
2023

Istituto Neurologico Mediterraneo
2020

Astronomical Observatory of Capodimonte
2020

Naples Anesthesia & Physician Associates
2014-2019

University of L'Aquila
2009

Cambridge University Press
2009

New York University Press
2009

St. Eugenio Hospital
2003-2008

An 8-month, double-blind, placebo-controlled, crossover trial of flunarizine in the prophylaxis migraine has been performed 70 children. After 4 weeks medication-free base-line observation, 35 children (group A) received (5 mg/day) and B) placebo over a 12-week period. 4-week washout they crossed treatments for another 12 weeks. Sixty-three patients completed trial. In both groups significantly reduced frequency average duration headache attacks. group A efficacy was maintained after last...

10.1046/j.1468-2982.1988.0801001.x article EN Cephalalgia 1988-03-01

Vestibular migraine is considered the most common cause of recurrent vertigo for which specific treatments are missing. Monoclonal antibodies against calcitonin gene-related peptide,, effective in preventing migraine. Since CGRP also detected human cochlear and vestibular organs it may play a role physiology.This prospective observational cohort study, aiming at evaluating efficacy erenumab, fremanezumab or galcanezumab treatment fifty patients. We assessed mean monthly days with headache...

10.1177/03331024231161809 article EN cc-by-nc Cephalalgia 2023-03-22

The aim of this study was to asses the clinical features, pattern healthcare and drug utilization migraine patients attending 10 Italian headache centres (HC). Migraine is underdiagnosed undertreated everywhere throughout world, despite its considerable burden. sufferers often deal with their problem alone using self-prescribing drugs, whereas triptans are used by a small proportion patients. All for first time HCs over 3-month period were screened migraine. underwent structured direct...

10.1111/j.1468-2982.2009.01874.x article EN Cephalalgia 2009-05-11

The objective of this paper was to assess prevalence and characteristics anxiety depression in migraine without aura tension-type headache, either isolated or combination. Although the association between headache psychiatric disorders is undisputed, patients with and/or have been frequently investigated different settings using tests, which prevents meaningful comparisons. Psychiatric comorbidity tested through structured interview MINI inventory 158 adults 216 persons plus headache. 49...

10.1007/s10194-010-0187-2 article EN cc-by-nc The Journal of Headache and Pain 2010-01-26

To assess the prevalence and possible pathogenetic involvement of raised intracranial pressure in patients presenting with unresponsive chronic migraine (CM), we evaluated opening (OP) clinical outcome a single cerebrospinal fluid withdrawal by lumbar puncture 44 consecutive diagnosed chronic/transformed evidence sinus stenosis at magnetic resonance venography. The large majority complained daily or near-daily headache. Thirty-eight (86.4 %) had an OP >200 mmH2O. Lumbar puncture-induced...

10.1007/s00415-014-7355-2 article EN cc-by Journal of Neurology 2014-04-29

To compare the effectiveness and safety of galcanezumab, fremanezumab, erenumab for treatment chronic episodic migraine, through real-world data.Monoclonal antibodies (mAbs) targeting calcitonin gene-related peptide (CGRP) pathway have been tested extensively in several clinical trials both showing high effectiveness, safety, tolerability; however, there are no prospective studies intending to their efficacy safety.This is a observational cohort study comparing profiles migraine. We enrolled...

10.1111/head.14528 article EN cc-by-nc-nd Headache The Journal of Head and Face Pain 2023-05-31

Cluster headache (CH) is characterized by severe, recurrent, unilateral attacks of extreme intensity and brief duration. Variants in a myriad genes were studied sporadic CH patients, often with conflicting results.We gene mutations some candidate genes, hypocretin receptor 2, Clock, alcohol dehydrogenase 4 (ADH4), 54 unrelated patients 200 controls 8 kindreds/families that included more affected nonaffected cases. Furthermore, we performed the whole-genome scanning comparative genomic...

10.1097/ajp.0000000000000075 article EN Clinical Journal of Pain 2014-01-27

Introduction The functional neuroimaging of headache patients has revolutionized our understanding the pathophysiology primary headaches, providing unique insights into these syndromes. Indeed, studies have shown activation specific brain structures, brainstem in migraine and posterior hypothalamus cluster (CH), as well other trigeminal autonomic cephalalgias. We describe findings a patient suffering from CH headache, investigated with magnetic resonance imaging (fMRI) during typical pain...

10.1177/0333102412474505 article EN Cephalalgia 2013-01-28
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