A5057467681- Cystic Fibrosis Research Advances
- Blood Coagulation and Thrombosis Mechanisms
- Neonatal Respiratory Health Research
- Hemophilia Treatment and Research
- Folate and B Vitamins Research
- Autism Spectrum Disorder Research
- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Platelet Disorders and Treatments
- Epigenetics and DNA Methylation
- Cannabis and Cannabinoid Research
- Tracheal and airway disorders
- Cancer-related gene regulation
- Chronic Myeloid Leukemia Treatments
- Cerebrovascular and Carotid Artery Diseases
- Molecular Biology Techniques and Applications
- Acute Myocardial Infarction Research
- HIV/AIDS drug development and treatment
- Pancreatic and Hepatic Oncology Research
- Nerve injury and regeneration
- Asthma and respiratory diseases
- Educational and Social Studies
- Hormonal Regulation and Hypertension
- Advanced biosensing and bioanalysis techniques
- Trace Elements in Health
Ceinge Biotecnologie Avanzate (Italy)
2012-2024
University of Naples Federico II
1996-2024
University of Molise
2004-2018
Tecnologie Avanzate (Italy)
2007
Wake Forest University
2002-2003
Merck & Co., Inc., Rahway, NJ, USA (United States)
2003
Fatebenefratelli Hospital
2002
Centro di Riferimento Oncologico della Basilicata
2002
Interventi Geo Ambientali (Italy)
2002
National Cancer Institute
2002
<h3>Context</h3> Brain-derived neurotrophic factor (BDNF) plays a pivotal role in the pathophysiology of suicidal behavior and<i>BDNF</i>levels are decreased brain and plasma suicide subjects. So far, mechanisms leading to downregulation of<i>BDNF</i>expression poorly understood. <h3>Objectives</h3> To test hypothesis that alterations DNA methylation could be involved dysregulation of<i>BDNF</i>gene expression <h3>Design</h3> Three independent quantitative techniques were performed on...
Background and Purpose— The association between obesity atherosclerotic disease is controversial. In the present analysis, we evaluated whether common carotid intima-media thickness (IMT) area, 2 markers of preclinical atherosclerosis, were increased in obese subjects. Methods— More than 5000 middle-aged women (n=5062; age, 30 to 69 years) living area Naples, Southern Italy, recruited for a prospective, currently ongoing study on etiology cardiovascular cancer female population (the Progetto...
Cystic fibrosis (CF) is the most frequent lethal genetic disorder among Caucasians. It depends on alterations of a chloride channel expressed by epithelial cells and encoded CFTR gene. Also using scanning techniques to analyze whole coding regions gene, mutations are not identified in up 10% CF alleles, such figure increases CFTR-related disorders (CFTR-RD). Other gene may be site causing-disease mutations. We searched for variants 1500 bp 3′ untranslated region, typical target microRNA...
Butyrate acts as energy source for intestinal epithelial cells and key mediator of several immune processes, modulating gene expression mainly through histone deacetylation inhibition. Thanks to these effects, butyrate has been proposed the treatment many diseases. Aim this study was investigate effect on a large series target genes encoding proteins involved in pro-inflammatory pathways. We performed quantitative real-time-PCR analysis 86 bearing pathways, before after exposure, primary...
<h3>Background</h3> The effect of complex alleles in cystic fibrosis (CF) is poorly defined for the lack functional studies. <h3>Objectives</h3> To describe genotype–phenotype correlation and results either vitro ex vivo studies performed on nasal epithelial cells (NEC) a cohort patients with CF carrying <i>cystic transmembrane conductance regulator</i> (<i>CFTR</i>) alleles. <h3>Methods</h3> We studied 70 homozygous, compound heterozygous or <i>CFTR</i> mutations:...
Abstract Background: Noise-induced cochlear epithelium damage can cause hearing loss in industrial workers. In experimental systems, noise induces the release of free radicals and may sensorial epithelium. Therefore, genes involved regulating reactive oxygen species manganese-superoxide dismutase (SOD2) antioxidant paraoxonase (PON) could influence cochlea vulnerability to noise. We evaluated whether susceptibility noise-induced (NIHL) is associated with SOD2, PON1, PON2 polymorphisms...
The last ten years have been characterized by an enormous step forward in the therapy and management of patients with Cystic Fibrosis (CF), thanks to development combination Transmembrane Receptor (CFTR) correctors potentiators. Specifically, approved triple elexacaftor/tezacaftor/ivacaftor has demonstrated improve lung function CF both homozygous Phe508del Phe508del/minimal genotypes. Here we assessed effect carrying genotype (n = 20) after one year treatments on liver nutrient absorption a...
Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared similarly aged men. Prothrombotic gene variants could play role as risk factors for AMI at age.We studied Factor V Leiden, FII G20210A, MTHFR C677T and beta-fibrinogen -455G>A by real-time PCR 955 (362 females) 698 (245 patients. The data were to those obtained 909 unrelated subjects (458 from the general population of same geographical area (southern Italy).In females,...
A clinical heterogeneity was reported in patients with Cystic Fibrosis (CF) the same CFTR genotype and between siblings CF.We investigated all aspects a cohort of 101 pairs CF (including 6 triplets) followed since diagnosis.Severe lung disease had 22.2% concordance sib-pairs, occurred early FEV1% at 12 years predictive severity adulthood. Similarly, liver (median: 15 years) showed 27.8% sib-pairs suggesting scarce contribution genetic factors; fact, only 2/15 discordant deficiency...
Cystic Fibrosis (CF) is one of the most common life shortening conditions in Caucasians. CF caused by mutations Transmembrane Conductance Regulator (CFTR) gene which result reduced or altered CFTR functionality. Several microRNAs (miRNAs) downregulate expression CFTR, thus causing exacerbating symptoms CF. In this context, design anti-miRNA agents represents a valid functional tool, but its translation to clinic might lead unpredictable side effects because interference with other genes...
Cluster headache (CH) is characterized by severe, recurrent, unilateral attacks of extreme intensity and brief duration. Variants in a myriad genes were studied sporadic CH patients, often with conflicting results.We gene mutations some candidate genes, hypocretin receptor 2, Clock, alcohol dehydrogenase 4 (ADH4), 54 unrelated patients 200 controls 8 kindreds/families that included more affected nonaffected cases. Furthermore, we performed the whole-genome scanning comparative genomic...
Recurrent (RP) and chronic pancreatitis (CP) may complicate Cystic Fibrosis (CF). It is still unknown if mutations in genes involved the intrapancreatic activation of trypsin (IPAT) or pancreatic secretion pathway (PSP) enhance risk for RP/CP patients with CF. We enrolled: 48 affected by CF complicated and, as controls 35 without 80 unrelated healthy subjects. tested a panel 8 IPAT, i.e. PRSS1, PRSS2, SPINK1, CTRC, CASR, CFTR, CTSB KRT8 23 additional implicated PSP. found 14/48 (29.2%) IPAT...
Cystic fibrosis (CF) is a genetic disease characterized by progressive decline of lung function and chronic airway inflammation. Adipose tissue, through adiponectin leptin, exerts several effects on energy metabolism inflammatory processes. This study evaluated the levels leptin in adult healthy subjects, patients with CF their correlation long-term physical activity. were divided into two groups (sedentary versus active) based regular activity over 3 years. Anthropometric serum biochemical...
Abstract Objective Cystic fibrosis (CF) is the most common inherited, life limiting condition among Caucasians. No healing therapy currently available for patients with CF. The aim of study was to define clinical, anthropometric and biochemical effects regular, supervised physical exercise in a large cohort Materials Methods Fifty‐nine adult CF that performed regularly last 3 years comparison 59 sex age matched sedentary were included study. Results Physical had significantly beneficial on:...