A5021763099- Nutritional Studies and Diet
- Cardiovascular Health and Disease Prevention
- Diet and metabolism studies
- Cutaneous Melanoma Detection and Management
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Blood Pressure and Hypertension Studies
- Cancer Risks and Factors
- Antioxidant Activity and Oxidative Stress
- Cancer Immunotherapy and Biomarkers
- Cerebrovascular and Carotid Artery Diseases
- Consumer Attitudes and Food Labeling
- Childhood Cancer Survivors' Quality of Life
- Estrogen and related hormone effects
- Immunotherapy and Immune Responses
- Lipoproteins and Cardiovascular Health
- Acute Lymphoblastic Leukemia research
- Cardiovascular Disease and Adiposity
- Metabolism, Diabetes, and Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Cancer survivorship and care
- Ovarian function and disorders
- SARS-CoV-2 and COVID-19 Research
- Blood Coagulation and Thrombosis Mechanisms
- Diabetes, Cardiovascular Risks, and Lipoproteins
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2002-2024
Cambridge University Press
2021
New York University Press
2021
Centro di Riferimento Oncologico
2021
Istituti di Ricovero e Cura a Carattere Scientifico
1995-2020
Tumori Foundation
2003-2020
Regione Campania
2014-2017
Onze Lieve Vrouwziekenhuis Hospital
2013
National Institutes of Health
2006
Tumour Institute of Tuscany
2000-2006
One of the aims EPIC study is to produce accurate descriptions dietary habits participants recruited in 27 centers 10 European countries. To do this, different assessment instruments were developed and applied capture wide range diets characterizing populations. Three food frequency questionnaires for Italy: one Varese, Turin Florence, Ragusa Naples. These inquired about eating over previous year completed by 46,839 Italian participants. Specially software analyzed responses linked them...
Background and Purpose— The association between obesity atherosclerotic disease is controversial. In the present analysis, we evaluated whether common carotid intima-media thickness (IMT) area, 2 markers of preclinical atherosclerosis, were increased in obese subjects. Methods— More than 5000 middle-aged women (n=5062; age, 30 to 69 years) living area Naples, Southern Italy, recruited for a prospective, currently ongoing study on etiology cardiovascular cancer female population (the Progetto...
Background The inflammatory pathology observed in severe COVID-19 disease caused by the 2019 novel acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized elevated serum levels of C reactive protein (CRP) and cytokines, including interferon gamma, interleukin 8 (IL-8), 6 (IL-6). Initial reports from outbreak Italy, China USA have provided anecdotal evidence improved outcomes with administration anti-IL-6 agents, large-scale trials evaluating these therapies are ongoing. Study...
Healthy lifestyles are associated with better health-related quality of life (HRQoL), favorable prognosis and lower mortality in breast cancer (BC) survivors. We investigated changes HRQoL after a 12-month lifestyle modification program 227 BC survivors participating DEDiCa trial (Mediterranean diet, exercise, vitamin D). was evaluated through validated questionnaires: EQ-5D-3L, EORTC-QLQ-C30 EORTC QLQ-BR23. Baseline were tested using analysis variance. Multiple regression analyses performed...
EPIC-Italy is the Italian section of a larger project known as EPIC (European Prospective Investigation into Cancer and Nutrition), prospective study on diet cancer carried out in 10 European countries. In period 1993-1998, completed recruitment 47,749 volunteers (15,171 men, 32,578 women, aged 35-65 years) 4 different areas covered by registries: Varese (12,083 volunteers) Turin (10,604) Northern part country; Florence (13,597) Ragusa (6,403) Central Southern Italy, respectively. An...
Objective: To determine whether an increase in dietary potassium intake from natural foods reduces the need for antihypertensive medication patients with essential hypertension. Design: Randomized, controlled trial 1-year follow-up. Setting: Hypertension outpatient clinic of a university hospital. Patients: Fifty-four well-controlled hypertension, 47 whom completed 1 year Intervention: Patients were randomly assigned to one two groups and given advice aimed at selectively increasing (group...
Abstract bjective: The aim of this study was to compare the quantities alcohol and types alcoholic beverages consumed, timing consumption, in centres participating European Prospective Investigation into Cancer Nutrition (EPIC). These centres, 10 countries, are characterised by widely differing drinking habits frequencies alcohol-related diseases. Methods: We collected a single standardised 24-hour dietary recall per subject from random sample EPIC cohort (36 900 persons initially 35 955...
Background: Several studies have shown that healthy lifestyles prevent the risk of breast cancer (BC) and are associated with better prognosis. It was hypothesized lifestyle strategies induce microRNA (miRNA) modulation that, in turn, may lead to important epigenetic modifications. The identification miRNAs BC, diet, physical activity give further insights into role played by interventions their efficacy for BC patients. To predict which be modulated diet patients, analyses different miRNA...
Evidence suggests a beneficial role of the Mediterranean Diet (MedDiet) on health-related quality life (HRQoL) in healthy subjects. HRQoL is relevant cancer therapy and disease outcomes, therefore we investigated association between adherence to MedDiet breast survivors participating multicentre trial DEDiCa. were assessed at baseline subgroup 309 women enrolled within 12 months diagnosis without metastasis (stages I-III, mean age 52±1 yrs, BMI 27±7 kg/m2). The 14-item PREDIMED questionnaire...
Abstract Background: In addition to their possible direct biological effects, plasma carotenoids can be used as biochemical markers of fruit and vegetable consumption for identifying diet–disease associations in epidemiological studies. Few studies have compared levels these between countries Europe. Objective: Our aim was assess the variability carotenoid within cohort European Prospective Investigation into Cancer Nutrition (EPIC). Methods: Plasma six – α-carotene, β-carotene,...
Abstract A link between unsaturated fatty acids or phytonutrients and reduced risk of colorectal cancer has been suggested. However, the effects higher intake dietary sources these nutrients, such as nuts seeds food group, are less clear. The objective this study was to determine nut seed on within European Prospective Investigation into Cancer Nutrition study, a large prospective cohort involving 10 countries. Total determined from country-specific questionnaires. data set included 478,040...
We evaluated 106 subjects with and 109 without a history of ischemic stroke. All were attending metabolic ward. The two groups compared for major risk factors events. A positive family complications atherosclerosis was more common in stroke than those without; moreover, plasma levels plasminogen activator inhibitor-1 (PAI-1) tissue-type (TPA) higher patients documented previous strong significant correlation found between TPA PAI-1 levels, an interaction age observed when the sample...
<h3>Aim</h3> In the context of Italian Multicentric Epidemiological Study on Risk Factors for Childhood Leukaemia and Non-Hodgkin9s Lymphoma (SETIL), risk childhood cancer was investigated in relation to parental occupational exposures. <h3>Methods</h3> All cases leukaemia non-Hodgkin9s lymphoma (NHL) children aged 0–10 years were identified. Controls chosen at random from local population each region. Parents interviewed using a structured questionnaire. The collected data blindly reviewed...
SARS-CoV-2 infection can impact the physical, cognitive, mental health of patients, especially in those recovered intensive care units. Moreover, it was proved that effects virus may persist for weeks or months. The term long-COVID post-COVID syndrome is commonly used indicating a variety physical and psychological symptoms continue after resolution acute phase. This narrative review aimed at providing an updated overview disorders COVID-19 survivors, by summarizing data already published...
COVID-19 is an unprecedented global pandemic. On 12 March 2020, a lockdown order was issued in Italy attempt to contain the health crisis. The study aimed assess impact of on diet, physical activity, sleep quality, and distress Italian cohort. An online anonymous interview, which included validated questionnaires created compare lifestyle habits pre- during lockdown. Data analysis from 604 subjects with mean age 29.8 years carried out using multivariate analysis. Compared pre-COVID-19 times,...
Abstract We evaluated the genotypes of angiotensin-converting enzyme (ACE) gene in 101 subjects with and 109 without a history ischemic stroke. All were attending metabolic ward. The two groups compared for major risk factors events. Genotypes determined by polymerase chain reaction oligonucleotide primers flanking polymorphic region intron 16 ACE gene. Deletion polymorphism (DD genotype) was shown to be more common stroke than those (relative risk, 1.76; confidence intervals, 1.02 3.05). A...
In this analysis of the data from a longitudinal study on coronary heart disease risk factors, it was found that participants screened few weeks after major disaster (earthquake) had higher rate, serum cholesterol levels, and triglyceride levels than matched were shortly before catastrophic event. The two groups did not differ with regard to their characteristics at baseline examination carried out 5 years previously. lack difference in blood pressure between exposed nonexposed could be...
The inflammatory potential of the diet decreased significantly after one-year nutrition counselling on Mediterranean and low glycemic index in women with breast cancer living Italy.
Obesity and metabolic disorders have been associated with poor outcomes in non-Mediterranean breast cancer (BC) patients. The purpose of this study was to investigate the prognostic potential anthropometric variables patients early BC living Southern Mediterranean region Italy. We enrolled 955 consecutive treated hospitals Naples between 2009 2013 (median follow-up 11.8-year ending 15/09/2022). Body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) syndrome (MetS) were...
Plasminogen activator inhibitor 1 (PAI-1) is a determinant of vascular events. Subjects in metabolic wards are at high risk for these The renin-angiotensin system modulates plasma PAI-1 levels. An insertion (4G)/deletion (5G) polymorphism involved the regulation circulating levels PAI-1. We have evaluated 208 individuals from our ward and correlated with 4G/5G genotype as well (homozygosity deletion polymorphism, DD genotype) angiotensin-converting enzyme (ACE) gene. Homozygosity (5G/5G) was...