A5064993921- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Hepatitis C virus research
- Immunotherapy and Immune Responses
- Celiac Disease Research and Management
- Helicobacter pylori-related gastroenterology studies
- T-cell and B-cell Immunology
- Viral-associated cancers and disorders
- Galectins and Cancer Biology
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- Wnt/β-catenin signaling in development and cancer
- Cancer Immunotherapy and Biomarkers
- Systemic Lupus Erythematosus Research
- Diabetes and associated disorders
- Microscopic Colitis
- CAR-T cell therapy research
- Digestive system and related health
- Immune Response and Inflammation
- HIV Research and Treatment
- Cytomegalovirus and herpesvirus research
- Reproductive System and Pregnancy
- Hepatitis B Virus Studies
Centro di Riferimento Oncologico
2013-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2007-2020
National Cancer Institute
2006-2007
University of Padua
1994
Background: Ocular adnexal lymphomas may be antigen-driven disorders; however, the source of putative antigen or antigens is still unknown. Hence, we assessed whether Chlamydiae infection associated with development ocular lymphomas. Methods: The presence Chlamydia psittaci, trachomatis, and pneumoniae DNA was investigated by polymerase chain reaction in 40 lymphoma samples, 20 nonneoplastic orbital biopsies, 26 reactive lymphadenopathy peripheral blood mononuclear cells (PBMCs) from 21...
Healthy lifestyles are associated with better health-related quality of life (HRQoL), favorable prognosis and lower mortality in breast cancer (BC) survivors. We investigated changes HRQoL after a 12-month lifestyle modification program 227 BC survivors participating DEDiCa trial (Mediterranean diet, exercise, vitamin D). was evaluated through validated questionnaires: EQ-5D-3L, EORTC-QLQ-C30 EORTC QLQ-BR23. Baseline were tested using analysis variance. Multiple regression analyses performed...
Background The variability in the association of host innate immune response to Hepatitis C virus (HCV) infection requires ruling out possible role KIR and HLA genotypes HCV-related disorders: therefore, we therefore explored relationships between KIR/HLA chronic HCV (CHC) as they relate risk hepatocarcinoma (HCC) or lymphoproliferative disease progression. Methods Findings We analyzed data from 396 HCV-positive patients with CHC (n = 125), HCC (118), diseases (153), 501 HCV-negative...
ABSTRACT T cells are exhausted and overexpress inhibitory molecules in chronic hepatitis C virus (HCV) infection. It is unclear whether this the cause or consequence of HCV persistence. By studying serial blood liver samples chimpanzees during acute infection, we demonstrate that early expression memory precursor marker CD127 on HCV-specific cells, but not those their ligands liver, predicts outcome
Objective To explore genes of the killer-cell immunoglobulin-like receptor (KIR) and HLA ligand their relationship with outcome metastatic colorectal cancer (mCRC) patients treated first-line 5-fluorouracil, leucovorin, irinotecan (FOLFIRI). Methods A total 224 mCRC were screened for KIR/HLA typing. The determination combinations was based upon gene content variants. Genetic associations complete response (CR), time to progression (TTP) overall survival (OS) evaluated by calculating odds...
INTRODUCTION: Chronic atrophic autoimmune gastritis (CAAG) can lead to the development of gastric neuroendocrine tumors (gNETs) and be accompanied by other diseases. This study aimed determine, in CAAG patients, association gNET development, prevalence diseases than CAAG, autoimmunity, with pepsinogen I, II, gastrin-17, Helicobacter pylori infection analysis. METHODS: We determined gNETs analyzed I gastrin-17 serum levels, H. all patients diagnosed at our hospital between 2013 2017. RESULTS:...
A positive family history is a strong and consistently reported risk factor for gastric cancer (GC). So far, it has been demonstrated that serum pepsinogens (PGs), gastrin 17 (G17) are useful screening individuals at elevated to develop atrophic gastritis but they suboptimal biomarkers screen GC. The main purpose of this study was investigate metabolomic profiles find additional could be integrated with PGs G17 improve the diagnosis GC selection first-degree relatives (FDR) higher...
Objective To screen and characterize germline variants for E-cadherin (CDH1) in non-hereditary gastric cancer (GC) patients subjects at risk of GC. Methods 59 GCs, first degree relatives (FDRs) GC, 20 autoimmune metaplastic atrophic gastritis (AMAGs) 52 blood donors (BDs) were analyzed CDH1 by direct sequencing, structural modelling bioinformatics. Functional impact on splicing was assessed intronic mutations. E-cadherin/β-catenin immunohistochemical staining mRNA quantification using RT-PCR...
Autoimmune atrophic gastritis (AAG) is associated with an increased risk of certain types gastric cancer (GC). Helicobacter pylori (H. pylori) infection may have a role in the induction and/or maintenance AAG and GC. Toll-like receptors (TLR) are essential for H. recognition subsequent innate adaptive immunity responses. This study therefore aimed to characterize TLR polymorphisms, features bacterial flagellin A samples from patients (n = 67), GC 114) healthy donors (HD; n 97). TLR5...
Two common mutations, 677 C-->T and a1298 A-->C, in the methylenetetrahydrofolate reductase gene (MTHFR) reduce activity of MTHFR folate metabolism. Familial aggregation a variable but significant proportion gastric cancer (GC) cases suggests importance genetic predisposition determining risk. In this study, we evaluate polymorphisms 57 patients with diagnosis GC, 37 history GC first-degree relatives (GC-relatives), 454 blood donors. Helicobacter pylori (HP) infection was also determined. An...
To explore the relationship between innate immunity and hepatitis C Virus (HCV) in determining risk of cirrhosis (CIR), hepatocellular carcinoma (HCC), mixed cryoglobulinemia syndrome (MCS) non-Hodgkin lymphoma (NHL), we investigated impact toll-like receptor-2 (TLR2) interleukin-28B (IL28B) genetic variants. TLR2 -174 del variant was associated with expression specific downstream molecules that drive different interleukins; rs12979860 Il28B important response to interferon-treatment...
Abstract Immunotherapy approaches targeting Epstein‐Barr virus (EBV)‐encoded antigens induce objective clinical responses only in a fraction of patients with undifferentiated nasopharyngeal carcinoma (UNPC). In the present study, we have characterized immunogenicity EBV‐encoded BARF1 oncogene aim to assess whether this protein could constitute new target antigen for immunotherapy setting. Spontaneous CD4+ and CD8+ T cell specific recombinant p29 were detected by IFN γ ‐ELISPOT both...
Despite the production of neutralizing antibodies to hepatitis C virus (HCV), many patients fail clear and instead develop chronic infection long-term complications. To understand how HCV perturbs antibody repertoire identify molecular features genes associated with either viral clearance or infection, we sequenced V(D)J region naïve memory B cells 6 persons who spontaneously resolved an (SR), 9 a newly diagnosed chronically evolving (CE), 7 healthy donors. In both cells, frequency use...
The mode of transmission human herpesvirus 8 (HHV8) was investigated in two seroepidemiological studies Swedish women who completed a questionnaire about sexual behavior. Seropositivity for HHV8 antibodies, measured using an indirect immunofluorescence assay, linked to high number (>10) partners (P < 0.004). It also correlated strongly with history other sexually transmitted diseases (STD; P 0.0001), particular Chlamydia trachomatis infection and condyloma acuminata. There appreciable...
This investigation was focused on the contribution of individual human leukocyte antigen (HLA)-DR and -DQ alleles to hepatitis C virus (HCV)+ non-Hodgkin's lymphoma (NHL), with without mixed cryoglobulinemia (MC), study whether HLA class II are expressed preferentially or equally in HCV-specific NHL. For this purpose, peripheral blood mononuclear cells were obtained from two groups patients HCV+ NHL MC (70 71 cases, respectively), 4575 donors. Eighty-three subjects HCV infection only, 118...
SUMMARY The kinetics and effects of in vivo spontaneous apoptosis activation-induced cell death (AICD) upon CD4+ CD8+ lymphocyte subsets CD4 naive numbers were studied HIV+ subjects with pretreatment values &gt; 200/mm3, who subsequently treated for 48 weeks HAART alone or combination six cycles subcutaneous IL-2. Irrespective the type treatment, patients showed a statistically significant increase counts after 4 weeks, although subset only increased significantly IL-2-treated at end...