A5068048791- Cancer therapeutics and mechanisms
- Colorectal Cancer Treatments and Studies
- Pharmacogenetics and Drug Metabolism
- Cancer Treatment and Pharmacology
- Drug Transport and Resistance Mechanisms
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Neutropenia and Cancer Infections
- Nanoparticle-Based Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Advanced biosensing and bioanalysis techniques
- Genetic factors in colorectal cancer
- Chronic Lymphocytic Leukemia Research
- Folate and B Vitamins Research
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
- RNA Interference and Gene Delivery
- Antibiotics Pharmacokinetics and Efficacy
- Colorectal Cancer Surgical Treatments
- Advanced Breast Cancer Therapies
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Acute Lymphoblastic Leukemia research
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
Centro di Riferimento Oncologico
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
National Cancer Institute
2002-2023
University of Trieste
1994-2021
University of Modena and Reggio Emilia
2020
Sorbonne Université
2019
Hôpital Charles-Foix
2019
Assistance Publique – Hôpitaux de Paris
2019
Azienda Ospedaliera Santa Maria Degli Angeli
1998-2017
Fondazione Italiana Fegato
2017
The high affinity folate binding protein (FBP) is overexpressed in ovarian cancers. However, its role the pathogenesis and biological behaviour of these neoplasms not clearly understood. Using monoclonal antibody (MAb) MOv 18 cytofluorimetric analysis, we investigated FBP expression frozen neoplastic tissues from 136 patients diagnosed with epithelial cancer. values were compared clinico-pathological characteristics (age, stage, histologic grade, type, DNA ploidy, percentage S-phase cells,...
Purpose UGT1A1*28 polymorphism has been associated with decreased glucuronidation of SN38, the active metabolite irinotecan. This could increase toxicity this agent. Patients and Methods In a prospective study, 250 metastatic colorectal cancer patients were treated irinotecan, fluorouracil, leucovorin as first-line treatment. was investigated respect to distribution hematologic nonhematologic toxicity, objective response rate, survival. Pharmacokinetics in subgroup (71 250) who had analyzed...
Despite scientific and clinical advances in the field of pharmacogenomics (PGx), application into routine care remains limited. Opportunely, several implementation studies programs have been initiated over recent years. This article presents an overview these identifies current research gaps. Importantly, one such gap is undetermined collective utility implementing a panel PGx-markers care, because evidence base currently limited to specific, individual drug-gene pairs. The Ubiquitous...
To demonstrate that exosomes (exo) could increase the therapeutic index of doxorubicin (DOX).Exosomes were characterized by nanoparticle tracking analysis and western blot. Tissue toxicity was evaluated histopathological drug efficacy measuring tumor volume. DOX biodistribution analyzed MS.Exosomal (exoDOX) avoids heart partially limiting crossing through myocardial endothelial cells. For this reason, mice can be treated with higher concentration exoDOX thus increasing as demonstrated in...
Purpose UGT1A1 ★ 28 is considered the main pharmacogenetic predictor of toxicity outcome irinotecan-treated patients. We evaluated effect other UGT1A variants and haplotypes involved in 7-ethyl-10-hydroxycamptothecin (SN-38) glucuronidation on severe efficacy fluorouracil, leucovorin, irinotecan (FOLFIRI). Patients Methods In addition to 28, 60, 93, UGT1A7 3, UGT1A9 22 were genotyped 250 metastatic colorectal cancer patients, associations with hematologic nonhematologic toxicity, objective...
PURPOSE We aimed to identify the maximum-tolerated dose (MTD) of irinotecan in patients with cancer UGT1A1*1/*1 and *1/*28 genotypes. hypothesize that without *28/*28 genotype tolerate higher doses irinotecan. PATIENTS AND METHODS Patients undergoing first-line treatment for metastatic colorectal (CRC) eligible plus infusional fluorouracil/leucovorin (FOLFIRI) were screened UGT1A1*28/*28 excluded from study. Fifty-nine white either *1/*1 or escalation The starting biweekly was 215 mg/m(2)...
To test the efficacy and toxicity of exosomal doxorubicin (exoDOX) compared with free doxorubicin.The cytotoxic effects exoDOX were tested in vitro nude mice by measuring tumor volume. The toxic evaluated bodyweight through histopathologic analyses. biodistribution DOX was assessed MS.In vivo studies showed that exosomes did not decrease DOX. Surprisingly, no cardiotoxicity as observed DOX-treated MS confirmed accumulation heart reduced approximately 40%.We demonstrated less than its altered...
There is the need for reproducible, simple, high-yielding synthetic protocols aimed at obtaining carbon dots (CDs) with controlled fluorescence, photothermal and photochemical behavior, surface properties, biocompatibility, tumor targeting ability, drug absorption biodistribution, uptake. This Letter describes a systematic study on effect of glucose, fructose, ascorbic acid as starting materials preparation highly luminescent CDs, characterized by blue emission. Their composition morphology...
Among the several delivery materials available so far, polysaccharides represent very attractive molecules as they can undergo a wide range of chemical modifications, are biocompatible, biodegradable, and have low immunogenic properties. Thus, contribute to significantly overcome limitation in use many types drugs, including anti-cancer drugs. The conventional drugs is hampered by their high toxicity, mostly depending on indiscriminate targeting both cancer normal cells. Additionally, for...
A novel human ferritin-based nanocarrier, composed of 24 modified monomers able to auto-assemble into a protein cage, was produced and used as selective carrier anti-tumor payloads. Each monomer derives from the genetic fusion two distinct modules, namely heavy chain ferritin (HFt) stabilizing/protective PAS polypeptide sequence rich in proline (P), serine (S), alanine (A) residues. Two genetically fused constructs containing polymers with 40- 75-residue lengths, respectively, were compared....
Abstract Cisplatin (CDDP) is commonly used to treat a multitude of tumors including sarcomas, ovarian and cervical cancers. Despite recent investigations allowed improve chemotherapy effectiveness, the molecular mechanisms underlying development CDDP resistance remain major goal in cancer research. Here, we show that mitochondrial morphology autophagy are altered different resistant cell lines. In osteosarcoma carcinoma, mitochondria fragmented closely juxtaposed endoplasmic reticulum; rates...
Overexpression of the folate binding protein (FBP) is a common feature in epithelial ovarian cancer, but its prognostic significance not clearly understood. We investigated whether FBP cancer specimens predictor response to chemotherapy and survival. Between 1990 1995, 99 patients with underwent primary surgery were treated chemotherapeutic regimens including platinum derivatives. First-line was performed 58 residual disease 41 without after laparotomy. expression level determined frozen by...
MTHFR is a critical enzyme that regulates the metabolism of folate and methionine, both which are important factors in DNA methylation synthesis. Subjects with 677C-->T variant have impaired remethylation Hcy to methionine could determine hyperhomocysteinemia. Remethylation into also affected by MTX treatment. Thus, combined effect between reduced activity polymorphism occur, leading toxicity. In clinical trial, 43 ovarian cancer patients were treated low doses MTX. During therapy, 12...