A5047238831- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Inflammatory Bowel Disease
- Histone Deacetylase Inhibitors Research
- Pharmacological Effects of Medicinal Plants
- Cancer Treatment and Pharmacology
- Chemotherapy-induced organ toxicity mitigation
- Mesenchymal stem cell research
- Silymarin and Mushroom Poisoning
- Bioactive Compounds and Antitumor Agents
- Genomics, phytochemicals, and oxidative stress
- Phytochemicals and Antioxidant Activities
- Barrier Structure and Function Studies
- DNA Repair Mechanisms
- RNA modifications and cancer
- Nanoparticle-Based Drug Delivery
- Free Radicals and Antioxidants
- Cancer therapeutics and mechanisms
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Biomedical Ethics and Regulation
- Cannabis and Cannabinoid Research
- Natural product bioactivities and synthesis
- Immune Cell Function and Interaction
- Tannin, Tannase and Anticancer Activities
Ospedale San Bortolo
2023-2025
University of Padua
2011-2024
International Renal Research Institute of Vicenza
2020-2022
Ospedale Maggiore
2020
University of Verona
2020
Pharmac
2016
Virgo
2016
CeMM Research Center for Molecular Medicine
2012
Cornell University
2002
Università Cattolica del Sacro Cuore
2001
Aminosalicylates, corticosteroids and immunosuppressants are currently the therapeutic choices in inflammatory bowel diseases (IBD), however, with limited remission often serious side effects. Meanwhile complementary alternative medicine (CAM) use is increasing, particularly herbal medicine. Boswellia serrata a traditional Ayurvedic remedy anti-inflammatory properties, of interest for its usefulness IBDs. The mechanism this pharmacological potential was investigated colonic epithelial cell...
// Daniela Catanzaro 1 , Edoardo Gaude 2 Genny Orso 3 Carla Giordano 4 Giulia Guzzo 5 Andrea Rasola Eugenio Ragazzi Laura Caparrotta Christian Frezza Monica Montopoli Department of Pharmaceutical and Pharmacological Sciences, University Padova, Italy MRC Cancer Unit, Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, UK IRCCS “E. Medea”, Conegliano, Radiological, Oncological Pathological Sapienza Rome, Roma, Correspondence to: Frezza, e-mail:...
Abstract Cisplatin (CDDP) is commonly used to treat a multitude of tumors including sarcomas, ovarian and cervical cancers. Despite recent investigations allowed improve chemotherapy effectiveness, the molecular mechanisms underlying development CDDP resistance remain major goal in cancer research. Here, we show that mitochondrial morphology autophagy are altered different resistant cell lines. In osteosarcoma carcinoma, mitochondria fragmented closely juxtaposed endoplasmic reticulum; rates...
Resistance to chemotherapeutic drugs is a major problem in cancer treatment. The search for new interventions able overcome this resistance may involve compounds of natural origin, such as flavonoids, ubiquitously present many foods. In the study, cytotoxic effects and cell cycle modulation flavonoid quercetin were investigated ovarian carcinoma (SKOV3) osteosarcoma (U2OS) human lines their cisplatin (CDDP)-resistant counterparts (SKOV3/CDDP U2OSPt cells, respectively). Quercetin (10-50 μM)...
The genetic and epigenetic factors underlying the variable penetrance of homoplasmic mitochondrial DNA mutations are poorly understood. We investigated a 16-year-old patient with hypertrophic cardiomyopathy harboring m.4277T>C mutation in mt-tRNA(Ile) (MTTI) gene. Skeletal muscle showed multiple respiratory chain enzyme abnormalities decreased steady-state level mutated mt-tRNA(Ile). Transmitochondrial cybrids grown on galactose medium demonstrated functional effect this cell viability,...
The relevance and incidence of intestinal bowel diseases (IBD) have been increasing over the last 50 years current therapies are characterized by severe side effects, making essential development new strategies that combine efficacy safety in management human IBD. Herbal products highly considered research aimed at discovering approaches for IBD therapy and, among others, Cannabis sativa L. has traditionally used centuries as an analgesic anti-inflammatory remedy also different...
Inflammatory bowel diseases, which consist of chronic inflammatory conditions the colon and small intestine, are considered a global disease our modern society. Recently, interest toward use herbal therapies for management diseases has increased because their effectiveness favourable safety profile, compared to conventional drugs. Boswellia serrata Roxb. Curcuma longa L. amongst most promising drugs, however, clinical in is limited little known on mechanism action. The aim this work was...
// Daniela Catanzaro 1, * , Silvia Nicolosi Veronica Cocetta 1 Marika Salvalaio Andrea Pagetta Eugenio Ragazzi Monica Montopoli 2 and Gianfranco Pasut 3 Department of Pharmaceutical Pharmacological Sciences, University Padua, Italy Venetian Institute Molecular Medicine, Padova, Veneto Oncology IOV, IRCCS, These authors have contributed equally to the work Correspondence to: Montopoli, email: monica.montopoli@unipd.it Pasut, gianfranco.pasut@unipd.it Keywords: Cisplatin; drug resistance;...
Inflammatory Bowel Diseases (IBD), are considered a growing global disease, with about ten million people being affected worldwide. Maintenance of intestinal barrier integrity is crucial for preventing IBD onset and exacerbations. Some recent patents regarding oily formulations containing probiotics (WO2010122107A1 WO2010103374A9) the use gastrointestinal complaints (US20110110905A1 US9057112B2) exist, or pending application.In this work, we studied effect fixed combination registered...
Fifteen plant polyphenols, including flavonoids, cinnamic acids, coumarins and capsaicin, were investigated for their capacity to suppress cell growth regulate the cycle of in vitro human ovarian carcinoma (2008 line) cervix squamous cells (A431), cisplatin (CDDP)-resistant subclones (C13 A431Pt, respectively). Evaluation cytotoxic effects polyphenols (0.01–100 μM) indicated that especially rhein quercetin almost equiactive wild type CDDP-resistant cells, indicating lack cross-resistance...
Skin is the essential barrier of human body which performs multiple functions. Endogenous factors, in concert with external assaults, continuously affect skin integrity, leading to distinct structural changes that influence not only appearance but also its various physiological Alterations functions lead an increased risk developing disease and side reactions, thus importance maintaining integrity epidermal slowing down aging process evident. Salvia haenkei (SH) has been recently identified...
The antiproliferative effect of the naturally occurring polyphenol chlorogenic acid (CGA) was evaluated in combination with either cisplatin or oxaliplatin human cervical carcinoma cell lines that were sensitive (A431) resistant to (A431Pt), order provide evidence overcome drug resistance. Cytotoxicity platinating drugs (IC50 - 10(-6) 10(-5) M) enhanced by 1-2 orders magnitude increasing incubation times (1, 4, and 24 hours) two lines. CGA treatment presented low cytotoxicity per se ~ 10(-4)...
Abstract Background During the coronavirus disease-2019 (COVID-19) pandemic, Italian hospitals faced most daunting challenges of their recent history, and only essential therapeutic interventions were feasible. From March to April 2020, Laboratory Advanced Cellular Therapies (Vicenza, Italy) received requests treat a patient with severe COVID-19 acute graft- versus -host disease umbilical cord-derived mesenchymal stromal cells (UC-MSCs). Access clinics was restricted due risk contagion....
Maintenance of intestinal barrier integrity is crucial for preventing inflammatory bowel diseases (IBDs) onset and exacerbations. In this work we study the effect a fixed combination Lactobacillus reuteri acidophilus herbal extracts in an vitro inflammation experimental model. Caco-2 cell monolayer was exposed to INF-γ+TNF-α or LPS; Trans Epithelial Electrical Resistance (TEER) paracellular permeability were investigated. ZO-1 occludin tight junctions (TJs) also...
Objective: Polycythemia Vera (PV) is a myeloproliferative neoplasm characterized by the overproduction of red blood cells. First-line therapies are directed at lowering hematocrit levels. After discovery mutation in Janus kinase 2 (JAK2V617F), JAK2 inhibitors have been tested as second-line therapies. Despite these approaches, there still need for major comprehension mechanisms involved PV erythrocytosis and more effective Angiotensin-converting enzyme (ACE) stimulates hematopoietic...
Abstract Background Glioblastoma is the most aggressive form of brain cancer, characterised by high proliferation rates and cell invasiveness. Despite advances in surgery radio-chemotherapy, patients continue to have poor prognoses, with a survival rate 14–15 months. Thus, new therapeutic strategies are needed. Non-ionising electromagnetic fields represent an emerging option given potential advantages safety, low toxicity possibility be combined other therapies. Methods Here, anticancer...