A5010571894- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Metal complexes synthesis and properties
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer therapeutics and mechanisms
- Pancreatic and Hepatic Oncology Research
- Lymphoma Diagnosis and Treatment
- Trace Elements in Health
- Acute Lymphoblastic Leukemia research
- Drug Transport and Resistance Mechanisms
- Cancer Immunotherapy and Biomarkers
- DNA Repair Mechanisms
- Ferrocene Chemistry and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal and Anal Carcinomas
- Nanoplatforms for cancer theranostics
- Biochemical and Molecular Research
- PARP inhibition in cancer therapy
- Surgical site infection prevention
University of Florence
2015-2024
University of Chieti-Pescara
2021-2024
ASST Fatebenefratelli Sacco
2018-2021
Queen's University Belfast
2018
National Health Service
2018
Ospedale San Giuseppe
2016
Institute of Cancer Research
2016
AC Camargo Hospital
2016
Istituto Oncologico Veneto
2009
Ca' Foncello Hospital
2009
High-resolution melting analysis (HRMA) provides a valid approach to efficiently detect DNA genetic and somatic mutations. In this study, HRMA was used for the screening of 116 colorectal cancers (CRCs) hot-spot mutations in KRAS BRAF oncogenes. Mutational hot spots on PIK3CA gene, exons 9 20, were also screened. Direct sequencing confirm characterize results. revealed abnormal profiles 65 CRCs (56.0%), 16 them harboring 2 different genes simultaneously. The frequency 17.2% (11.2% exon 6.0%...
PURPOSE We aimed to identify the maximum-tolerated dose (MTD) of irinotecan in patients with cancer UGT1A1*1/*1 and *1/*28 genotypes. hypothesize that without *28/*28 genotype tolerate higher doses irinotecan. PATIENTS AND METHODS Patients undergoing first-line treatment for metastatic colorectal (CRC) eligible plus infusional fluorouracil/leucovorin (FOLFIRI) were screened UGT1A1*28/*28 excluded from study. Fifty-nine white either *1/*1 or escalation The starting biweekly was 215 mg/m(2)...
Two novel gold carbene compounds, namely, chlorido (1-butyl-3-methyl-imidazole-2-ylidene) gold(I) (1) and bis(1-butyl-3-methyl-imidazole-2-ylidene) (2), were prepared characterized as prospective anticancer drug candidates. These compounds consist of a center linearly coordinated either to one N-heterocyclic (NHC) chloride ligand or two identical NHC ligands (2). Crystal structures solved for both the resulting structural data being in good agreement with expectations. We wondered whether...
Pre-therapeutic DPYD pharmacogenetic test to prevent fluoropyrimidines (FL)-related toxicities is not yet common practice in medical oncology. We aimed at investigating the clinical validity of genetic analysis a large series oncological patients. Six hundred three cancer patients, treated with FL, have been retrospectively tested for eight polymorphisms (DPYD-rs3918290, DPYD-rs55886062, DPYD-rs67376798, DPYD-rs2297595, DPYD-rs1801160, DPYD-rs1801158, DPYD-rs1801159, DPYD-rs17376848)...
A variety of gold(III) and gold(I) derivatives 2-(2′-pyridyl)benzimidazole (pbiH) were synthesized fully characterized their antiproliferative properties evaluated in a representative ovarian cancer cell line. The complexes include the mononuclear species [(pbi)AuX2] (X = Cl, 1; OAc, 2), [(pbiH)AuCl] (3), [(pbiH)Au(PPh3)][PF6] (4-PF6), [(pbi)Au(L)] (L PPh3, 5; TPA, 6), binuclear gold(I)/gold(I) gold(I)/gold(III) [(PPh3)2Au2(μ2-pbi)][PF6] (10-PF6), [ClAu(μ3-pbi)AuCl2] (7),and...
In recent years, a few successful attempts were made to repurpose the clinically approved antiarthritic gold drug, Auranofin (AF), as an anticancer agent. The present study shows that iodido(triethylphosphine)gold(I) complex, (Et3PAuI hereafter)—an AF analogue where thiosugar ligand is simply replaced by one iodide ligand—manifests solution chemistry resembling of and exerts similar cytotoxic proapoptotic effects on A2780 human ovarian cancer cells in vitro. However, when evaluated...
Transcriptomic profiling of colorectal cancer (CRC) has led to identification four consensus molecular subtypes (CMS1-4), which have prognostic value in stage II/III disease. More recently, the Colorectal Cancer Intrinsic Subtypes (CRIS) classification system helped define biology specific epithelial component tumors. However, clinical these classifications predicting response standard-of-care adjuvant chemotherapy remains unknown.Using samples from 4 European sites, we assembled a novel CRC...
Au(NHC) and Au(NHC)2, i.e. a monocarbene gold(I) complex the corresponding bis(carbene) complex, are two structurally related compounds, endowed with cytotoxic properties against several cancer cell lines. Herein, we explore molecular cellular mechanisms at basis of their cytotoxicity in A2780 human ovarian cells. Through comparative proteomic analysis, demonstrated that number modulated proteins is far larger Au(NHC)2-treated than Au(NHC)-treated Both gold compounds mainly affected...
// Ida Landini 1 , Andrea Lapucci Alessandro Pratesi 2 Lara Massai Cristina Napoli 3 Gabriele Perrone Pamela Pinzani 4 Luigi Messori 2, * Enrico Mini 1, and Stefania Nobili 3, Department of Experimental Clinical Medicine, University Florence, Firenze, Italy Chemistry “Ugo Schiff”, Health Sciences, Biomedical These authors have contributed equally to this work Correspondence to: Mini, email: enrico.mini@unifi.it Nobili, stefania.nobili@unifi.it Messori, luigi.messori@unifi.it...