A5022778554- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- Organometallic Compounds Synthesis and Characterization
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Protein Interaction Studies and Fluorescence Analysis
- Trace Elements in Health
- Click Chemistry and Applications
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- DNA and Nucleic Acid Chemistry
- Organometallic Complex Synthesis and Catalysis
- Nanoparticle-Based Drug Delivery
- Computational Drug Discovery Methods
- Lanthanide and Transition Metal Complexes
- Catalytic Alkyne Reactions
- Synthetic Organic Chemistry Methods
- Advanced biosensing and bioanalysis techniques
- Magnetism in coordination complexes
- Chemical Synthesis and Analysis
- Nanoparticles: synthesis and applications
- Metal-Catalyzed Oxygenation Mechanisms
- Nanocluster Synthesis and Applications
- Corrosion Behavior and Inhibition
- Crystal structures of chemical compounds
- Biochemical effects in animals
University of Pisa
2020-2024
University of Florence
2016-2021
The solution behavior of auranofin, Et3PAuCl and Et3PAuI, as well their interactions with hen egg white lysozyme, single strand oligonucleotide, ds-DNA were comparatively analyzed through NMR spectroscopy, ESI-MS, ethidium bromide displacement, DNA melting viscometric tests. cytotoxic effects toward representative colorectal cancer cell lines found to be strong similar in the three cases a good correlation could established between cytotoxicity ability inhibit thioredoxin reductase;...
Due to the so-called "antibiotic resistance crisis" new antibacterial agents are urgently sought treat multidrug-resistant pathogens. A group of gold- or silver-based complexes, general formula [M(PEt3 )X] (with M=Au Ag, and X=Cl, Br I), alongside with three complexes bearing a positive negative charge-[Au(PEt3 )2 ]Cl, K[Au(CN)2 ] [Ag(PEt3 ]NO3 -were prepared comparatively tested auranofin on representative panel pathogens including Gram-positive, Gram-negative Candida strains....
In recent years, a few successful attempts were made to repurpose the clinically approved antiarthritic gold drug, Auranofin (AF), as an anticancer agent. The present study shows that iodido(triethylphosphine)gold(I) complex, (Et3PAuI hereafter)—an AF analogue where thiosugar ligand is simply replaced by one iodide ligand—manifests solution chemistry resembling of and exerts similar cytotoxic proapoptotic effects on A2780 human ovarian cancer cells in vitro. However, when evaluated...
Electrospray ionization mass spectrometry (ESI MS) is a powerful investigative tool to analyze the reactions of metallodrugs with proteins and peptides characterize resulting adducts. Here, we have applied this type approach four experimental anticancer gold(III) compounds for which extensive biological mechanistic data had previously been gathered, namely, Auoxo6, Au2phen, AuL12, Aubipyc. These were reacted two representative proteins, i.e., human serum albumin (HSA) carbonic anhydrase I...
The discovery of the antineoplastic properties cisplatin in 1965 by Rosenberg and co-workers, originated a renewed attraction for metal complexes medicinal applications. Indeed, after its first outstanding clinical results, chemists involved research field readily started to study safer more effective alternatives itself. In this frame, decades intensive mainly focused on classical Pt(II) compounds, also platinum(IV)-based compounds have been taken into account. reason interest is that,...
The reactions of auranofin and three pseudohalide derivatives with bovine serum albumin were explored by ESI-Q-TOF mass spectrometry; a detailed molecular description the resulting adducts is achieved revealing even subtle differences in reactivity within this series gold(I) complexes. Our study shows that kind investigative approach, formerly applied to interactions metal-based drugs small model proteins MW 10-15 kDa, e.g., cytochrome c lysozyme, may now be extended success far larger such...
Abstract The silver(I) N ‐heterocyclic carbene (NHC) complex bis(1‐(anthracen‐9‐ylmethyl)‐3‐ethylimidazol‐2‐ylidene) silver chloride ([Ag(EIA) 2 ]Cl), bearing two anthracenyl fluorescent probes, has been synthesized and characterized. [Ag(EIA) ]Cl is stable in organic solvents under physiological conditions, shows potent cytotoxic effects vitro toward human SH‐SY5Y neuroblastoma cells. interactions of with a few model biological targets have studied as well its ability to be internalized...
The medicinal gold(III) dithiocarbamato complex AuL12 forms a stable adduct with bovine serum albumin. crystal structure reveals that single gold(I) center is bound to Cys34, the ligand being released. To best of our knowledge, this first for gold
Au(PEt3)I (AF-I hereafter), the iodide analog of FDA-approved drug auranofin (AF is a promising anticancer agent that produces its pharmacological effects through interaction with non-genomic targets such as thioredoxin reductase system. AF-I endowed very favorable biochemical profile showing potent in vitro cytotoxic activity against several cancer types including ovarian and colorectal cancer. Remarkably, recent publication, some us reported induces an almost complete rapid remission...
PtI<sub>2</sub>(DACH) has been prepared and tested. shows different chemical biological features than oxaliplatin, manifesting cellular effects nearly comparable to those of parent drug in three lines CRC.
A panel of four novel gold(I) complexes, inspired by the clinically established gold drug auranofin (1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate), was prepared and characterized. All these compounds feature replacement triethylphosphine ligand parent compound with a trimethylphosphite ligand. The linear coordination around center is completed Cl−, Br−, I− or thioglucose tetraacetate (SAtg). in-solution behavior as well their interactions some representative model...
Abstract Chloro(triethylphosphine)gold(I), (Et 3 PAuCl hereafter), is an Auranofin (AF)-related compound showing very similar biological and pharmacological properties. Like AF, Et exhibits potent antiproliferative properties in vitro toward a variety of cancer cell lines promising anticancer drug candidate. We wondered whether encapsulation might lead to improved profile also considering the likely reduction unwanted side-reactions that are responsible for adverse effects inactivation. was...
Metal-based drugs represent a rich source of chemical substances potential interest for the treatment COVID-19. To this end, we have developed small but representative panel nine metal compounds, including both synthesized and commercially available complexes, suitable medical application tested them in vitro against SARS-CoV-2 virus. The screening revealed that three compounds from panel, i.e., organogold(III) compound Aubipyc, ruthenium(III) complex KP1019, antimony trichloride (SbCl3),...