A5065695489- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Surgical Treatments
- Nutritional Studies and Diet
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Eosinophilic Esophagitis
- Online and Blended Learning
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Global Cancer Incidence and Screening
- Inflammatory mediators and NSAID effects
- Education and Critical Thinking Development
- Vitamin D Research Studies
- Cancer Genomics and Diagnostics
- Cancer Risks and Factors
- COVID-19 and healthcare impacts
- Helicobacter pylori-related gastroenterology studies
Queen's University Belfast
2016-2025
University of Ulster
2012-2024
Royal Victoria Hospital
2012-2024
The Northern Ireland Cancer Centre
2021-2023
Queens University
2011-2022
Cancer Research UK
2022
University of Southampton
2006-2022
National Cancer Registry
2011-2021
National Health Service
2013-2018
Ulster Hospital
2018
QuPath is new bioimage analysis software designed to meet the growing need for a user-friendly, extensible, open-source solution digital pathology and whole slide image analysis. In addition offering comprehensive panel of tumor identification high-throughput biomarker evaluation tools, provides researchers with powerful batch-processing scripting functionality, an extensible platform which develop share algorithms analyze complex tissue images. Furthermore, QuPath's flexible design makes it...
Barrett's esophagus (BE) is a premalignant lesion that predisposes to esophageal adenocarcinoma. However, the reported incidence of adenocarcinoma in patients with BE varies widely. We examined risk malignant progression using data from Northern Ireland Register (NIBR), one largest population-based registries worldwide, which includes every adult diagnosed between 1993 and 2005. followed 8522 BE, defined as columnar lined epithelium or without specialized intestinal metaplasia (SIM), until...
Abstract QuPath is new bioimage analysis software designed to meet the growing need for a user-friendly, extensible, open-source solution digital pathology and whole slide image analysis. In addition offering comprehensive panel of tumor identification high-throughput biomarker evaluation tools, provides researchers with powerful batch-processing scripting functionality, an extensible platform which develop share algorithms analyze complex tissue images. Furthermore, QuPath’s flexible design...
Abstract We introduce the AusTraits database - a compilation of values plant traits for taxa in Australian flora (hereafter AusTraits). synthesises data on 448 across 28,640 from field campaigns, published literature, taxonomic monographs, and individual taxon descriptions. Traits vary scope physiological measures performance (e.g. photosynthetic gas exchange, water-use efficiency) to morphological attributes leaf area, seed mass, height) which link aspects ecological variation. contains...
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs; encoded by PRKDC) functions in DNA non-homologous end-joining (NHEJ), the major double strand break (DSB) rejoining pathway. NHEJ also during lymphocyte development, joining V(D)J recombination intermediates antigen receptor gene assembly. Here, we describe a patient with compound heterozygous mutations PRKDC, low DNA-PKcs expression, barely detectable DNA-PK activity, and impaired DSB repair. In heterologous expression system,...
<h3>Objective</h3> Endoscopic surveillance of Barrett9s oesophagus (BO) provides an opportunity to detect early stage oesophageal adenocarcinoma (OAC). We sought determine the proportion OAC patients with a prior diagnosis BO on population basis and evaluate influence survival, taking into account lead length time biases. <h3>Design</h3> A retrospective population-based study all in Northern Ireland between 2003 2008. was determined by linkage register. Stage distribution at histological...
Background While current research is largely consistent as to the harms of heavy drinking in terms both cancer incidence and mortality, there are disparate messages regarding safety light-moderate alcohol consumption, which may confuse public health messages. We aimed evaluate association between average lifetime intakes risk mortality. Methods findings report a population-based cohort study using data from 99,654 adults (68.7% female), aged 55–74 years, participating U.S. Prostate, Lung,...
Aims Establishing the mismatch repair (MMR) status of colorectal cancers is important to enable detection underlying Lynch syndrome and inform prognosis therapy. Current testing typically involves either polymerase chain reaction (PCR)‐based microsatellite instability (MSI) or MMR protein immunohistochemistry (IHC). The aim this study was compare these two approaches in a large, population‐based cohort stage 2 3 colon cancer cases Northern Ireland. Methods results used Promega pentaplex...
Abstract Patients with hematological malignancies are at increased risk of severe COVID-19 outcomes due to compromised immune responses, but the insights these studies have been intrinsic limitations in study design. Here we present PROSECO prospective observational ( NCT04858568 ) on 457 patients lymphoma that received two or three vaccine doses. We show undetectable humoral responses following doses 52% undergoing active anticancer treatment. Moreover, 60% anti-CD20 therapy had antibodies...
Abstract CDKN2A is a tumor suppressor located in chromosome 9p21 and frequently lost Barrett’s esophagus (BE) esophageal adenocarcinoma (EAC). How other gene co-deletions affect EAC evolution remains understudied. We explored the effects of loss EACs cancer progressor non-progressor BEs with matched genomic, transcriptomic clinical data. Despite its driver role, BE prevents initiation by counterselecting subsequent TP53 alterations. predict poor patient survival but not through...