A5031632170- Esophageal Cancer Research and Treatment
- Multiple Myeloma Research and Treatments
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Esophageal and GI Pathology
- Colorectal Cancer Screening and Detection
- Inflammatory mediators and NSAID effects
- HER2/EGFR in Cancer Research
- Nutritional Studies and Diet
- Peripheral Neuropathies and Disorders
- Gastroesophageal reflux and treatments
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Pancreatic and Hepatic Oncology Research
- Estrogen and related hormone effects
- Helicobacter pylori-related gastroenterology studies
- Cancer Risks and Factors
- Genetic factors in colorectal cancer
- Head and Neck Cancer Studies
- Mycobacterium research and diagnosis
- Nutrition and Health in Aging
- Endometriosis Research and Treatment
- Alcohol Consumption and Health Effects
- Endometrial and Cervical Cancer Treatments
- Gut microbiota and health
Queen's University Belfast
2015-2025
University of Ulster
2017-2023
Royal Victoria Hospital
2017-2023
Victoria Hospital
2017
GTx (United States)
2017
National Cancer Institute
2014
University of Malaya
2014
Institute of Public Health
2013
BackgroundTo examine global patterns of gastric cancer in 2020 and the projected burden 2040.MethodsData on primary were extracted from GLOBOCAN database for year 2020. Age-standardized incidence mortality rates calculated by sex, country, world region level human development index (HDI) 185 countries. The predicted 2040 was based demographic projections.FindingsIn total, ∼1.1 million new cases 770,000 deaths estimated Incidence average 2-fold higher males than females (15.8 7.0 per 100,000,...
Background While current research is largely consistent as to the harms of heavy drinking in terms both cancer incidence and mortality, there are disparate messages regarding safety light-moderate alcohol consumption, which may confuse public health messages. We aimed evaluate association between average lifetime intakes risk mortality. Methods findings report a population-based cohort study using data from 99,654 adults (68.7% female), aged 55–74 years, participating U.S. Prostate, Lung,...
There is increasing evidence indicating a role for Fusobacterium nucleatum (F. nucleatum) in colorectal cancer (CRC) development and prognosis. This study evaluated F. as prognostic biomarker, by assessing its association with post-diagnosis survival from CRC. From September 2008 to April 2012 CRC patients (n = 190) were recruited three hospitals within the Czech Republic. DNA copies measured adjacent non-malignant tumor tissues using quantitative real-time PCR. Cox Proportional Hazards (HR)...
Abstract Background A causal role of high-risk HPV in oesophageal adenocarcinoma development has been hypothesised, but longitudinal evidence is limited. This study aims to investigate a potential infectious agents the malignant progression Barrett’s oesophagus. Methods Using retrospective nested case-control design, index biopsies were retrieved for individuals within Northern Ireland oesophagus register who subsequently progressed ( n = 150) and matched non-progressors 298). Index assessed...
INTRODUCTION: Gastrointestinal cancers show an unexplained male predominance, but few prospective studies have investigated sex hormones and gastrointestinal cancer risk. This study aimed to determine the impact of circulating on risk esophageal, gastric, colorectal in men women. METHODS: We included 219,425 147,180 women from UK Biobank. Sex were quantified using chemiluminescent immunoassay. identified registry linkages. hormone concentrations Cox proportional hazards regression. RESULTS:...
Controversy remains as to whether poor oral health is independently associated with gastrointestinal cancers, due potential confounding by smoking, alcohol and nutrition. The aim of this study was investigate the association between conditions cancer risk.
The roles of fruits and vegetables in colorectal cancer development are unclear. Few prospective studies have assessed the association with adenoma, a known precursor to cancer. Our aim was evaluate between fruit vegetable intake by evaluating risk incident recurrent adenoma Study participants were identified from intervention arm Prostate, Lung, Colorectal Ovarian Cancer Screening Trial. Fruit measured using self-reported dietary questionnaire. Total not associated reduced or overall, but...
Background Few observational studies have assessed the role of physical activity in oesophago‐gastric cancer risk. Objective This prospective cohort study aimed to assess association between and risk oesophageal or gastric cancer. Methods A 359,033 adults aged 40–69 years were identified from UK Biobank, which recruited participants 2006 2010. Adjusted hazard ratios (HRs) 95% confidence intervals (CIs) for associations self‐reported levels screen‐based sedentary behaviour calculated using...
Summary Background A risk prediction model containing sex, smoking history, Barrett's oesophagus length and presence of low‐grade dysplasia was found to identify individuals at a higher progression oesophageal adenocarcinoma or high‐grade dysplasia. Aim To externally validate the predicting from neoplasia assess predictive utility additional factors. Methods We conducted retrospective cohort study among population‐based Northern Ireland register with histologically confirmed diagnosis (with...
Incidence of upper gastrointestinal cancers the oesophagus and stomach show a strong unexplained male predominance. Hormonal reproductive factors have been associated with in women but there is little available data on men. To investigate this, we included 219,425 men enrolled UK Biobank 2006-2010. Baseline assessments provided information hormonal (specifically hair baldness, number children fathered, relative age at first facial voice broke) incident oesophageal or gastric were identified...
Excessive lower oesophageal sphincter relaxation increases gastro‐oesophageal acid reflux, an adenocarcinoma risk factor. Medications that relax this (benzodiazepines, calcium channel blockers, nitrates, β2 agonists and xanthines) could promote cancer. These medications were investigated in two independent datasets. In the Scottish Primary Care Clinical Informatics Unit (PCCIU) database, a nested case–control study of cancer was performed using GP prescription records. Conditional logistic...