A5048916329- Immune cells in cancer
- Colorectal Cancer Screening and Detection
- Cancer Immunotherapy and Biomarkers
- Cardiac, Anesthesia and Surgical Outcomes
- History of Medical Practice
- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Ferroptosis and cancer prognosis
- Brain Metastases and Treatment
- Clinical practice guidelines implementation
- Cancer Cells and Metastasis
- Breast Cancer Treatment Studies
- Bladder and Urothelial Cancer Treatments
- Ferrocene Chemistry and Applications
- BRCA gene mutations in cancer
- Breast Lesions and Carcinomas
- Reproductive Health and Contraception
- Integrated Circuits and Semiconductor Failure Analysis
- Cancer Mechanisms and Therapy
- Breast Implant and Reconstruction
- Birth, Development, and Health
- Real-Time Systems Scheduling
- COVID-19 and healthcare impacts
- Reproductive System and Pregnancy
- Hydrogen's biological and therapeutic effects
University of Medicine and Health Sciences
2025
Royal College of Surgeons in Ireland
2024
St. James's Hospital
1991-2022
Trinity College Dublin
2021-2022
Cancer Institute (WIA)
2021
Queen's University Belfast
2020
University of Limerick
2006
University of Zimbabwe
1998
Molecular Medicine Ireland
1995
Aims Establishing the mismatch repair (MMR) status of colorectal cancers is important to enable detection underlying Lynch syndrome and inform prognosis therapy. Current testing typically involves either polymerase chain reaction (PCR)‐based microsatellite instability (MSI) or MMR protein immunohistochemistry (IHC). The aim this study was compare these two approaches in a large, population‐based cohort stage 2 3 colon cancer cases Northern Ireland. Methods results used Promega pentaplex...
In the last decade, poly (ADP-ribose) polymerase (PARP) inhibitors have been approved in treatment of several cancers, such as breast and ovarian cancer. This article aims to discuss current uses, limitations, future directions for PARP (PARPis) Following results OlympiAD EMBRACA trials, PARPis were HER2-negative cancer with a germline BRCA mutation. We reviewed this class drugs' mechanism action, efficacy, well further studies that discussed resistance, impaired homologous recombination...
The overamplification of human epidermal growth factor (HER2) in breast cancer (BC) has been the subject numerous research publications since its discovery 1987. This is first bibliometric analysis (BA) conducted on HER2-positive (HER2+) BC. purpose this BA to analyze published HER2+ BC from 1987 2024, highlighting most significant scientific literature, as well main contributing authors and journals, evaluating impact clinical lab-based research.
Abstract Background Divergent estrogen receptor (ER) and HER2 status with breast cancer disease progression has important consequences for clinical management long-term survival. Molecular subtype expression is dynamic influenced by therapeutic intervention the metastatic environment. There remains however, a lack of data regarding mechanism switching subsequent consequences. Methods We undertook study neoadjuvant inhibitor treated patients (n=161) to determine consequence treatment...
Abstract Background Breast cancer brain metastasis is a rising occurrence, necessitating better understanding of the mechanisms involved for effective management. metastases diverge notably from primary tumor, with gains in kinase and concomitant losses steroid signaling observed. In this study, we explored role receptor RET promoting breast provide rationale targeting receptor. Methods expression was characterized cohort patients metastatic tumors. functionality assessed using...
Use of immune checkpoint blockade to enhance T cell-mediated immunity within the hostile tumour microenvironment (TME) is an attractive approach in oesophageal adenocarcinoma (OAC). This study explored effects TME, including nutrient deprivation and hypoxia, on (IC) expression cell phenotypes, potential use nivolumab function under such conditions.ICs were upregulated stromal cells PD-L2, CTLA-4 TIGIT. OAC patient-derived PBMCs co-cultured with OE33 LAG-3 downregulated co-stimulatory marker...
Radioresistance remains a significant challenge in treating pancreatic ductal adenocarcinoma (PDAC), contributing to the poor survival rates of this cancer. MicroRNAs (miRs) are small non-coding RNA molecules that may play an essential role regulating radioresistance by altering levels oxidative stress. In study, we investigated and potential mechanisms linking miR-31 PDAC radioresistance. A pCMV-miR vector containing mimic was stably expressed into miR-31-deficient cell line, BxPC-3....
Abstract Chemotherapy upregulates immune checkpoint (IC) expression on the surface of tumour cells and IC-intrinsic signalling confers a survival advantage against chemotherapy in several cancer-types including oesophageal adenocarcinoma (OAC). However, pathways mediating chemotherapy-induced IC upregulation mechanisms employed by ICs to protect OAC remain unknown. Longitudinal profiling revealed that FLOT-induced OE33 was sustained for up 3 weeks post-treatment, returning baseline upon...
Recent studies have demontrated that immune checkpoint receptors are expressed on the surface of oesophageal adenocarcinoma (OAC) cells and might confer a survival advantage. This study explores role PD-1 TIGIT signalling in OAC either promoting or inhibiting under characteristic features tumour microenvironment including nutrient-deprivation hypoxia. normal pre-malignant epithelial this expression significantly decreases along normal- Barrett's Oesophagus- disease sequence. However,...
Statecharts are commonly used in the specification of reactive systems. They useful introducing modular and hierarchical features to classical finite-state machines (FSMs). UML statecharts gaining popularity for modelling real-time embedded software. However, weak their support absolute time they do not formally verification methods. Timed automata models, on other hand, rich formal solutions. In this paper statechart method timed compared. A case study model an ATM output buffer switch is...
Abstract Introduction Brain metastasis (BM) occurs in 15-30% of breast cancer (BC) cases. In the era personalised medicine, knowledge BM subtype is increasing importance. However, there often discordance between primary (BP) and its BM. Improvements stereotactic radiosurgery neuroradiology have greatly reduced number patients undergoing surgical resection. Therefore, identifying poses a therapeutic challenge. Methods This study included 116 with brain on CTRIAL-IE 09/07. Clinical was...
The expression of estrogen receptor (ER) and human epidermal growth factor receptor-2 (HER2) in breast cancer can change response to treatment pivotally influence tumor behavior clinical management [1]. Receptor discordance has been observed at various distant metastatic site (bone, lung, liver, brain), with a routine loss ER gains HER2 reported [2]. This responsiveness both inhibitor endocrine therapies. Although the mechanisms underlying changes are not fully understood, we recently ESR1...
Abstract Chemotherapy upregulates immune checkpoint (IC) expression on the surface of tumour cells and IC-intrinsic signalling confers a survival advantage against chemotherapy in several cancer-types including oesophageal adenocarcinoma (OAC). However, pathways mediating chemotherapy-induced IC upregulation mechanisms employed by ICs to protect OAC remain unknown.Longitudinal profiling revealed that FLOT-induced OE33 was sustained for up 3 weeks post-treatment, returning baseline upon...