A5081605391- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Antimicrobial Resistance in Staphylococcus
- Antibiotics Pharmacokinetics and Efficacy
- Infective Endocarditis Diagnosis and Management
- Antibiotic Use and Resistance
- Inflammatory Bowel Disease
- Microscopic Colitis
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Pharmaceutical studies and practices
- Clostridium difficile and Clostridium perfringens research
- Colorectal Cancer Screening and Detection
- Streptococcal Infections and Treatments
- Memory Processes and Influences
- Infectious Aortic and Vascular Conditions
- Interprofessional Education and Collaboration
- Nematode management and characterization studies
- Digestive system and related health
- Musculoskeletal synovial abnormalities and treatments
- COVID-19 and healthcare impacts
- Child and Animal Learning Development
- Island Studies and Pacific Affairs
- Traumatic Brain Injury Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Imperial College London
2019-2024
Christchurch Hospital
2004-2023
Tulane University
2023
St Mary's Hospital
2022
Imperial College Healthcare NHS Trust
2021
Canterbury Health Laboratories
2015
University of Otago
2015
University of Colorado Health
2010
Research Network (United States)
2010
University of Missouri–Kansas City
2010
Abstract La Cour, P. & Gallagher, K. (1990). Presentation and evaluation of Rivermead Behavioural Memory Test. Nordisk Psykologi, 42, 130–141. The article presents an the Test, a test battery for illuminating impaired memory function. RBMT has recently been published in Danish together with short review its background contents. Results from 10 examinations where both traditional were applied lead to discussion regarding tests merits shortcomings. shown be benefit everyday functions are estimated.
Objective. To determine the epidemiology, clinical features, and microbiology of adult native joint septic arthritis in Canterbury, New Zealand, over a 5-year period individuals with without an underlying rheumatic disorder. Methods. Patients were identified retrospectively classified by Newman’s criteria. The characteristics described comparisons made between those disease. Results. Two hundred forty-eight cases (mean age 60, range 16–97 yrs) overall incidence rate 12.0/100,000/year (95% CI...
Abstract Faecal or biopsy samples are frequently used to analyse the gut microbiota, but issues remain with provision and collection of such samples. Rectal swabs widely-utilised in clinical practice previous data demonstrate their potential role microbiota analyses; however, studies date have been heterogenous, there a particular lack concerning utility for analysis microbiota’s functionality metabolome. We compared paired stool rectal swab from healthy individuals investigate whether...
Aims The aims of the study were a) to determine if there is evidence saturable protein binding cefazolin in plasma across range concentrations achieved clinically (between patient variability) and b) investigate whether also evident from trough peak same (within variability). Methods Unbound total measured patients who treated with intravenously by continuous infusion or intermittent injection. In (i) single random samples taken one series patients. (ii) paired (troughs peaks) a second...
<b>PURPOSE</b> This qualitative study examined the barriers to adopting depression care management among 42 primary clinicians in 30 practices. <b>METHODS</b> The RESPECT-Depression trial worked collaboratively with 5 large health organizations (and 60 practices) implement and disseminate an evidence-based intervention. used semistructured interviews from practice sites, 18 managers, 7 mental professionals explore experience perceptions for patients. Subject selection 4 waves of was driven...
Recurrent Clostridioides difficile infection (CDI) in patients with inflammatory bowel disease (IBD) is a clinical challenge. Fecal microbiota transplantation (FMT) has emerged as recurrent CDI therapy. Anecdotal concerns exist regarding worsening of IBD activity; however, prospective data among are limited. Secondary analysis from an open-label, prospective, multicenter cohort study 2 or more episodes was performed. Participants underwent single FMT by colonoscopy (250 mL, healthy universal...
Abstract Background Urinary and faecal metabolic profiling have been extensively studied in gastrointestinal diseases as potential diagnostic markers, to enhance our understanding of the intestinal microbiome pathogenesis these conditions. The impact bowel cleansing on has investigated several studies, but limited just one study metabolome. Aim To compare effects composition microbiome, urine Methods Urine samples were obtained from eleven patients undergoing colonoscopy at baseline, then...
Exposure to repeated mild blast traumatic brain injury (mbTBI) is common in combat soldiers and the training of Special Forces. Evidence suggests that exposure a or subthreshold can cause serious long-lasting impairments, but mechanisms causing these symptoms are unclear. In this study, we characterise effects single tightly coupled mbTBI Sprague-Dawley rats exposed shockwaves generated using shock tube. The primary outcomes functional neurologic function (unconsciousness, neuroscore, weight...
Objectives: The aim of this study was to investigate the temperature profile home intravenous (iv) antibiotic reservoirs and stability 16 megaunits benzylpenicillin sodium in 120 mL chloride 0.9% at constant variable temperatures.
<i>Background:</i> Making the kind of improvement changes necessary to move toward a patient-centered medical home will continue challenge small, independent primary care practices. Here we describe further analysis successful program understand roles coleaders change management process. <i>Methods:</i> Through an collaborative trained 2 (a physician and non-physician) from 16 small practices institute depression improvements. These participated in 3 learning sessions that provided content...
We examined the safety and clinical outcomes of outpatient parenteral antibiotic therapy (OPAT) for patients with infective endocarditis (IE) in Christchurch, New Zealand.Demographic data were collected from all adult treated IE over 5 years. Outcomes stratified by receipt at least partial OPAT vs entirely hospital-based therapy.There 172 episodes between 2014 2018. was administered 115 cases (67%) a median 27 days after 12 inpatient treatment. In cohort, viridans group streptococci...
Abstract Background Mesalazine (5-ASA) is a key initial treatment of ulcerative colitis (UC); recent studies have highlighted the role gut microbiota in 5-ASA metabolism. There no established means predicting outcome. We sought to investigate changes and metabolome with treatment, whether such may reflect clinical outcomes. Methods Longitudinal faeces, serum urine samples were collected from patients newly diagnosed UC before after treatment. documented longitudinal compared baseline...
Abstract Background Crohn’s Disease (CD) and ulcerative colitis (UC) are the two main sub-types of Inflammatory Bowel disease (IBD), which affect 300–500 per 100,000 people within Europe, with an increasing incidence. Long-term outcomes have been reported cohorts Korean Scandinavian populations, but long-term UK data limited. Methods Data were prospectively collected from IBD cohort over a 10-year period. 90 patients included (47 CD, 36 UC, 7 IBD-unclassified). Phenotypic (Montreal...