A5067856565- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Thyroid and Parathyroid Surgery
- Breast Implant and Reconstruction
- Shoulder and Clavicle Injuries
- Inflammatory Biomarkers in Disease Prognosis
- Parathyroid Disorders and Treatments
- Breast Lesions and Carcinomas
- PARP inhibition in cancer therapy
- Acute Myeloid Leukemia Research
- Cancer Treatment and Pharmacology
- DNA Repair Mechanisms
- Organ Donation and Transplantation
- Lung Cancer Treatments and Mutations
- Ferrocene Chemistry and Applications
- Intraperitoneal and Appendiceal Malignancies
- Integrated Circuits and Semiconductor Failure Analysis
- Chronic Myeloid Leukemia Treatments
- Radiopharmaceutical Chemistry and Applications
- Genetic and Kidney Cyst Diseases
- BRCA gene mutations in cancer
- Organ and Tissue Transplantation Research
- Cancer Immunotherapy and Biomarkers
- Advanced Breast Cancer Therapies
Royal College of Surgeons in Ireland
2019-2025
Beaumont Hospital
2023-2025
University of Medicine and Health Sciences
2025
Bon Secours Hospital Dublin
2023
Abstract Background The current standard of care in the neoadjuvant setting for high-risk HER2-positive (HER2 +) breast cancer is to combine systemic chemotherapy with dual HER2 blockade, trastuzumab and pertuzumab. Targeted therapies have significantly improved outcomes patients cancer. To improve treatment-associated toxicity, chemotherapy-sparing approaches are currently being investigated. Trastuzumab deruxtecan (T-DXd) an HER2-directed antibody–drug-conjugate (ADC) promising results...
In the last decade, poly (ADP-ribose) polymerase (PARP) inhibitors have been approved in treatment of several cancers, such as breast and ovarian cancer. This article aims to discuss current uses, limitations, future directions for PARP (PARPis) Following results OlympiAD EMBRACA trials, PARPis were HER2-negative cancer with a germline BRCA mutation. We reviewed this class drugs' mechanism action, efficacy, well further studies that discussed resistance, impaired homologous recombination...
The overamplification of human epidermal growth factor (HER2) in breast cancer (BC) has been the subject numerous research publications since its discovery 1987. This is first bibliometric analysis (BA) conducted on HER2-positive (HER2+) BC. purpose this BA to analyze published HER2+ BC from 1987 2024, highlighting most significant scientific literature, as well main contributing authors and journals, evaluating impact clinical lab-based research.
Abstract Background Divergent estrogen receptor (ER) and HER2 status with breast cancer disease progression has important consequences for clinical management long-term survival. Molecular subtype expression is dynamic influenced by therapeutic intervention the metastatic environment. There remains however, a lack of data regarding mechanism switching subsequent consequences. Methods We undertook study neoadjuvant inhibitor treated patients (n=161) to determine consequence treatment...
Abstract Introduction Transversus abdominis plane (TAP) block has been shown to be an effective technique in providing post-operative analgesia across a range of intra-abdominal surgeries. Laparoscopic-assisted TAP (LTAP) is recent advancement this technique. This study aimed evaluate the effectiveness LTAP compared port site infiltration (PSI) patients undergoing laparoscopic appendicectomy. Methods A single-blinded randomised controlled trial was performed compare standard PSI after...
Electrosurgical devices are commonly used during mastectomy for simultaneous dissection and haemostasis, can provide potential benefits regarding vessel lymphatic ligation. The aim of this prospective RCT was to assess whether using a vessel-sealing device (LigaSure™) improves perioperative outcomes compared with monopolar diathermy when performing simple mastectomy.
Abstract Introduction Brain metastasis (BM) occurs in 15-30% of breast cancer (BC) cases. In the era personalised medicine, knowledge BM subtype is increasing importance. However, there often discordance between primary (BP) and its BM. Improvements stereotactic radiosurgery neuroradiology have greatly reduced number patients undergoing surgical resection. Therefore, identifying poses a therapeutic challenge. Methods This study included 116 with brain on CTRIAL-IE 09/07. Clinical was...
Abstract Background Approximately 1 in 5 patients with autosomal dominant polycystic kidney disease (ADPKD) will undergo a native nephrectomy their lifetime. These can be emergent or planned and the indications range from space for transplant, pain, hematuria frequent urinary tract infections (UTIs). Due to diverse nature of presentations, there is lack certainty about outcomes optimal management. Aims This study aimed evaluate preoperative perioperative/postoperative complications this...
Ectopic parathyroid adenomas represent an important cause of refractory hyperparathyroidism. While most ectopic mediastinal can be accessed through a transcervical approach, this is not always feasible, posing significant challenge.
The expression of estrogen receptor (ER) and human epidermal growth factor receptor-2 (HER2) in breast cancer can change response to treatment pivotally influence tumor behavior clinical management [1]. Receptor discordance has been observed at various distant metastatic site (bone, lung, liver, brain), with a routine loss ER gains HER2 reported [2]. This responsiveness both inhibitor endocrine therapies. Although the mechanisms underlying changes are not fully understood, we recently ESR1...
Background: Pertuzumab, an anti-human epidermal growth factor receptor 2/3 (HER2/HER3) monoclonal antibody, has been demonstrated to be effective in the treatment of HER2-positive breast cancer. It was initially licensed Ireland for metastatic cancer 2015, but is now also used neoadjuvant and adjuvant settings primary with high-risk features recurrence. The aim assess current prescribing practices pertuzumab (Perjeta) HER2+ patients one eight Irish designated surgical centres, which...
Acromioclavicular joint (ACJ) injury is a common orthopaedic condition accounting for over 40 % of all shoulder injuries. The purpose this study to assess the research trends and characteristics top 50 cited articles on ACJ instability.