A5009847003- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Acute Myeloid Leukemia Research
- Chronic Disease Management Strategies
- Primary Care and Health Outcomes
- Adipose Tissue and Metabolism
- Cystic Fibrosis Research Advances
- Cardiovascular and exercise physiology
- Neuropeptides and Animal Physiology
- Global Health and Surgery
- Renin-Angiotensin System Studies
- Patient Satisfaction in Healthcare
- Healthcare Policy and Management
- Chronic Myeloid Leukemia Treatments
- Liver Disease Diagnosis and Treatment
- Exercise and Physiological Responses
- Down syndrome and intellectual disability research
- Tracheal and airway disorders
- Frailty in Older Adults
- Acute Lymphoblastic Leukemia research
- Analytical Methods in Pharmaceuticals
- Stress Responses and Cortisol
- Eicosanoids and Hypertension Pharmacology
- Neonatal Respiratory Health Research
- Antibiotics Pharmacokinetics and Efficacy
Children's Health Ireland at Crumlin
2019-2020
Our Lady's Hospital
2019
St. James's Hospital
2017
Royal College of Surgeons in Ireland
1994-1997
Coombe Women & Infants University Hospital
1997
We have investigated the subtype of α 2 ‐adrenoceptor mediating prejunctional inhibition cardioacceleration in pithed rat heart comparison with ligand binding sites. In rats, ‐adrenoceptors were terms ability antagonists to shift inhibitory potency agonist, xylazine, against tachycardia a single electrical stimulus given via pithing rod. Antagonist at was correlated antagonist affinity sites membranes kidney and submandibular gland labelled [ 3 H]‐yohimbine. The correlation best for 2D site...
Background: Children with trisomy 21 have several clinical complications such as a variety of dysmorphic features, congenital malformations and endocrine abnormalities for example. An important complication Down Syndrome (DS) is that they may also develop leukaemia. Acute myeloid leukaemia (AML) the type haematological malignancy most commonly reported in this population. A subtype AML called M7 (as classified by FAB system) has an incidence nearly 200 times greater compared to children...
<h3>Background</h3> Haematological abnormalities are common in children with trisomy 21. These have a remarkably high risk of acute leukaemia. The incidence myeloid leukaemia is 150 fold greater young DS compared to the same age without DS. Acute Megakaryoblastic Leukaemia (AMKL) subtype and most type under 4 years age. AMKL often preceded by transient neonatal pre-leukaemic syndrome, called Transient Myeloproliferative Disorder (TMD). Although TMD spontaneously resolves, 20–30% these...