A5043058962- Hydrogels: synthesis, properties, applications
- Polysaccharides Composition and Applications
- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- Crystallization and Solubility Studies
- RNA Interference and Gene Delivery
- Cystic Fibrosis Research Advances
- Advanced MRI Techniques and Applications
- Advanced Drug Delivery Systems
- biodegradable polymer synthesis and properties
- Polysaccharides and Plant Cell Walls
- Atomic and Subatomic Physics Research
- Protein purification and stability
- Advanced Cellulose Research Studies
- Advanced biosensing and bioanalysis techniques
- Surfactants and Colloidal Systems
- Advanced Polymer Synthesis and Characterization
- Electrospun Nanofibers in Biomedical Applications
- Rheology and Fluid Dynamics Studies
- NMR spectroscopy and applications
- Analytical Chemistry and Chromatography
- Supramolecular Self-Assembly in Materials
- DNA and Nucleic Acid Chemistry
- Inhalation and Respiratory Drug Delivery
- Dysphagia Assessment and Management
University of Trieste
2015-2024
Ospedale di Cattinara
2013-2017
The respiratory mucus, a viscoelastic gel, effectuates primary line of the airway defense when operated by mucociliary clearance. In chronic diseases (CRDs), such as asthma, obstructive pulmonary disease (COPD), and cystic fibrosis (CF), mucus is overproduced its solid content augments, changing structure properties determining derangement essential mechanisms against opportunistic microbial (virus bacteria) pathogens. This ensues in damaging airways, leading to vicious cycle obstruction...
Among the several delivery materials available so far, polysaccharides represent very attractive molecules as they can undergo a wide range of chemical modifications, are biocompatible, biodegradable, and have low immunogenic properties. Thus, contribute to significantly overcome limitation in use many types drugs, including anti-cancer drugs. The conventional drugs is hampered by their high toxicity, mostly depending on indiscriminate targeting both cancer normal cells. Additionally, for...
A simple relation between pendant groups of polymers in hydrogels is introduced to determine the crosslink density (complex) hydrogel systems (mixtures 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) modified nanocellulose, alginate, scleroglucan and Laponite addition crosslinking agents). Furthermore, rheological properties their great potential connection design complex with desired have been thoroughly investigated. Hydrogel structures governing internal friction flow resistance were...
Agarose is a natural polysaccharide known for its ability to form thermoreversible hydrogels. While the effects of curing temperature and concentration on mechanical properties have been discussed in literature, role ionic strength has less studied. In present manuscript, we investigate supporting salt cation (i.e. Na+ or Li+, neighbors Hofmeister series), setting performance agarose Compressive rheological measurements show that salts reduce immediate elastic response hydrogels, with Li+...
Short peptide hydrogels are attractive biomaterials but typically suffer from limited mechanical properties. Inclusion of other nanomaterials can serve the dual purpose hydrogel reinforcement and conferring additional physicochemical properties ( e. g., self-healing, conductivity), as long they do not hamper self-assembly. In particular, nanocarbons ideal candidates, their have demonstrated great potential in nanocarbon-polymer gel for tissue engineering or drug delivery. Recently,...
The design of multi-stimuli-responsive vehicles for the controlled and localized release drugs is a challenging issue increasingly catching attention many research groups working on advanced treatment hard-to-close wounds. In this work, thermo- pH-responsive hydrogel (P-CHP407) was prepared from an ad hoc synthesized amphiphilic poly(ether urethane) (CHP407) exposing significant amount –COOH (8.8 ± 0.9 nmol/gpolymer). exposure acid moieties in P-CHP407 led to slightly lower initial gelation...
Eight-armed PEG, molecular mass 10 kDa, was functionalized with furyl and maleimide groups, respectively; the obtained macromonomers were cross-linked via Diels–Alder chemistry. The mesh size (ξ) of prepared hydrogels determined by swelling studies, rheology, low field NMR spectroscopy. in vitro release fluorescein isothiocyanate labeled dextrans (FDs) bevacizumab investigated. average (ξavg) increased from 5.8 ± 0.1 nm to 56 13 during degradation, as studies. result rheological measurements...
Benznidazole (BNZ) serves as the primary drug for treating Chagas Disease and is listed in WHO Model List of Essential Medicines Children. Herein, a new child-friendly oral BNZ delivery platform developed form supramolecular eutectogels (EGs). EGs address BNZ's poor bioavailability provide flexible twice-daily dose stick-pack format. This green sustainable formulation strategy relies on gelation drug-loaded Natural Deep Eutectic Solvents (NaDES) with xanthan gum (XG) water. Specifically,...
Here we focus the attention on physical characteristics of a highly biocompatible hydrogel made up crosslinked alginate and Pluronic F127 (PF127). This is composite polymeric blend propose for artery endoluminal delivery an emerging class molecules named nucleic acid based drugs (NABDs). The characterization our gel, i.e. mesh size distribution PF127–alginate mutual organization after crosslinking, can significantly determine NABDs release kinetics. Thus, to explore these aspects, different...
Abstract Sol-gel transition of carboxylated cellulose nanocrystals has been investigated using rheology, SAXS, NMR and optical spectroscopies to unveil the distinctive roles ultrasound treatments addition various cations. Besides fiber fragmentation, sonication treatment induces fast gelling solution. The gelation is independent cations, while final rheological properties are highly influenced by type, concentration sequence operations since cations must be added prior produce stiff gels....
The focus of this paper is on the theoretical interpretation Low Field Nuclear Magnetic Resonance (LF-NMR) data regarding hydrogels architecture and most interesting applications LF-NMR presented by research group at 6<sup>th</sup> IAPC Symposium held in Zagreb (HR) September 2017. Particular attention devoted to determination mesh size distribution gels polymeric network pore microporous systems such as scaffolds, bones, porous gels. In addition, we report a very recent...
This work reports on a novel method to synthesize hydrophobically-modified hydrogels by curing epoxy monomers with amines. The resulting networks contain hydrophilic poly(ethylene glycol) (PEG) segments, poly(propylene (PPG) and C18 alkyl segments. By varying the content of different hydrophilic-lipophilic balance (HLB) are obtained. All show an amphiphilic behavior, swelling considerably both in organic solvents aqueous media. In latter they display thermosensitive which is highly affected...
The focus of this work is on the characterization hydrophobically-modified polyethylene glycol hydrogels, to be used as drug delivery systems, by means combined rheology and low field Nuclear Magnetic Resonance. Indeed, these two techniques allowed understanding how transient physical bonds deriving from hydrophobic association superimpose pre-existing covalent bonds. We found that improvement can achieved not only increasing content segments but also using thermal treatments after hydrogel...
This paper focuses on a thermodynamic model built to predict the reduction of organic drug melting temperature and enthalpy with nanocrystal size decrease. Indeed, this valuable information enables us evaluate increase solubility, an aspect paramount importance for poorly water-soluble drugs since solubility is reflected in bioavailability enhancement. In particular, considers effect nanocrystals shape (spherical, cylindrical, parallelepiped-shaped) morphology (from platelet needle...