A5027395380- Metabolism, Diabetes, and Cancer
- Genomics, phytochemicals, and oxidative stress
- Nitric Oxide and Endothelin Effects
- Biochemical Analysis and Sensing Techniques
- Phytochemicals and Antioxidant Activities
- Adenosine and Purinergic Signaling
- Protein Hydrolysis and Bioactive Peptides
- Free Radicals and Antioxidants
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Fatty Acid Research and Health
- Nuts composition and effects
- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Caveolin-1 and cellular processes
- Synthesis and biological activity
- Redox biology and oxidative stress
- Cancer, Lipids, and Metabolism
- Synthesis and Biological Evaluation
- Ion Transport and Channel Regulation
- Coenzyme Q10 studies and effects
- Mitochondrial Function and Pathology
- Nutrition, Genetics, and Disease
- Antioxidant Activity and Oxidative Stress
- Pancreatic function and diabetes
- Vitamin C and Antioxidants Research
University of Bologna
2016-2025
Malaghan Institute of Medical Research
2008
University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
2008
Stevia rebaudiana Bertoni is a shrub having high content of sweet diterpenoid glycosides in its leaves, mainly stevioside and rebaudioside A, which are used as noncaloric, natural sweeteners. The aim this study was to deepen the knowledge about insulin‐mimetic effect exerted by four different mixtures steviol glycosides, rich neonatal rat cardiac fibroblasts. potential antioxidant activity these also assessed, oxidative stress associated with diabetes. Likewise insulin effect, caused an...
This paper reports the synthesis of compounds formed by two indole systems separated a heterocycle (pyridine or piperazine). As primary screening, new were submitted to National Cancer Institute for evaluation antitumor activity in human cell line screen. The pyridine derivatives far more active than piperazine derivatives. For study mechanism action, most subjected COMPARE analysis and further biological tests including proteasome inhibition plasma membrane electron transport. compound...
Among health-promoting phytochemicals in whole grains, phenolic compounds have gained attention as they strong antioxidant properties and can protect against many degenerative diseases. Aim of this study was to profile grain extracts one modern five old common wheat (Triticum aestivum L.) varieties evaluate their potential antiproliferative or cytoprotective effect different cell culture systems.Wheat were characterized terms activity composition (HPLC/ESI-TOF-MS profile, polyphenol...
Caffeic, syringic, and protocatechuic acids are phenolic derived directly from food intake or come the gut metabolism of polyphenols. In this study, antioxidant activity these compounds was at first evaluated in membrane models, where caffeic acid behaved as a very effective chain-breaking antioxidant, whereas syringic were only retardants lipid peroxidation. However, all three acted good scavengers reactive species cultured cells subjected to exogenous oxidative stress produced by low level...
Extracts from Stevia rebaudiana Bertoni, a plant native to Central and South America, have been used as sweetener since ancient times. Currently, extracts are largely noncaloric high-potency biosweetener alternative sugar, due the growing incidence of type 2 diabetes mellitus, obesity, metabolic disorders worldwide. Despite large number studies on steviol glycosides in vivo , little is reported concerning cellular molecular mechanisms underpinning beneficial effects human health. The effect...
Astaxanthin is a red orange xanthophyll carotenoid produced mainly by microalgae but which can also be chemically synthesized. As demonstrated several studies, this lipophilic molecule endowed with potent antioxidant properties and able to modulate biological functions. Unlike synthetic astaxanthin, natural astaxanthin (NAst) considered safe for human nutrition, its production eco-friendly. The activity of depends on bioavailability, which, in turn, related hydrophobicity. In study, we...
GLUT1 is the predominant glucose transporter in leukemia cells, and modulation of transport activity by cytokines, oncogenes or metabolic stresses essential for their survival proliferation. However, molecular mechanisms allowing to control trafficking degradation are still under debate. In this study we investigated whether plasma membrane cholesterol depletion plays a role M07e human megakaryocytic line. To purpose, effect methyl-β-cyclodextrin (MBCD) on both was compared that cytokine...
Benznidazole (BNZ) serves as the primary drug for treating Chagas Disease and is listed in WHO Model List of Essential Medicines Children. Herein, a new child-friendly oral BNZ delivery platform developed form supramolecular eutectogels (EGs). EGs address BNZ's poor bioavailability provide flexible twice-daily dose stick-pack format. This green sustainable formulation strategy relies on gelation drug-loaded Natural Deep Eutectic Solvents (NaDES) with xanthan gum (XG) water. Specifically,...
The mechanism involved in the prosurvival effect of interleukin-3 on human acute myeloid leukaemia cell line M07e is investigated. A decrease intracellular reactive oxygen species (ROS) content, glucose transport activity and survival was observed presence inhibitors plasma membrane ROS sources, such as diphenylene iodonium apocynin, by small interference RNA for Nox2. Moreover, IL-3 incubation stimulated synthesis Nox2 cytosolic sub-unit p47phox transporter Glut1. Thus, inhibition...
Amniotic fluid stem cells (AFSCs) are characterized in vivo by a unique niche guarantying their homeostatic role the body. Maintaining functionality of ex for clinical applications requires continuous improvement cell culture conditions. Cellular redox status plays an important biology as long reactive oxygen species (ROS) concentration is finely regulated and adverse effects excluded. The aim this study was to investigate protective effect two antioxidants, sulforaphane (SF)...
The present study aimed to develop a novel formulation containing glutathione (GSH) as an oral antioxidant therapy for the treatment of oxidative stress-related intestinal diseases. To this purpose, solid lipid microparticles (SLMs) with Dynasan 114 and mixture 118 were produced by spray congealing technology. obtained SLMs had main particle sizes ranging from 250 355 µm, suitable administration. GSH was efficiently loaded into at 5% or 20% w/w encapsulation process did not modify its...
Castanea sativa cultivation has been present in Mediterranean regions since ancient times. In order to promote a circular economy, it is of great importance valorize chestnut groves’ by-products. this study, leaves and spiny burs from twenty-four trees were analyzed by 1H NMR metabolomics provide an overview their phytochemical profile. The Orthogonal Projections Latent Structures Discriminant Analysis (OPLS-DA) performed on these data allowed us distinguish ‘Marrone’ ‘Castagna’, the latter...
Neuroinflammation, which is mainly triggered by microglia, a key contributor to multiple neurodegenerative diseases. Natural products, and in particular Cannabis sativa L., due its richness phytochemical components, represent ideal candidates counteract neuroinflammation. We previously characterized different C. commercial varieties showed significantly chemical profiles. On these bases, the aim of this study was evaluate essential oils aqueous distillation residues from inflorescences three...
The discovery of superoxide-generating enzymes homologues phagocytic NAD(P)H oxidase, the Nox family, has led to concept that reactive oxygen species (ROS) are 'intentionally' generated with biological functions in various cell types. In this study, by treating an acute leukaemic line different antioxidants, ROS generation was shown be crucially involved modulation glucose transport (mediated Glut1), which is frequently up-regulated cancer cells. Then, study tried elucidate source(s) and...
Caveolae/lipid rafts are membrane-rich cholesterol domains endowed with several functions in signal transduction and caveolin-1 (Cav-1) has been reported to be implicated regulating multiple cancer-associated processes, ranging from tumor growth multidrug resistance angiogenesis. Vascular endothelial factor receptor-2 (VEGFR-2) Cav-1 frequently colocalized, suggesting an important role played by this interaction on cancer cell survival proliferation. Thus, our attention was directed a...