A5073603262- Mesenchymal stem cell research
- Seismic Performance and Analysis
- Vibration Control and Rheological Fluids
- Tissue Engineering and Regenerative Medicine
- Nuts composition and effects
- 3D Printing in Biomedical Research
- Extracellular vesicles in disease
- Microfluidic and Bio-sensing Technologies
- Pluripotent Stem Cells Research
- Masonry and Concrete Structural Analysis
- Natural product bioactivities and synthesis
- Cellular Mechanics and Interactions
- Insect and Pesticide Research
- Pancreatic function and diabetes
- Traditional Chinese Medicine Analysis
- Electrospun Nanofibers in Biomedical Applications
- Bee Products Chemical Analysis
- Structural Engineering and Vibration Analysis
- Neonatal Respiratory Health Research
- Plant and Fungal Interactions Research
- Healthcare and Venom Research
- Tryptophan and brain disorders
- Fluid Dynamics and Vibration Analysis
- Genomics, phytochemicals, and oxidative stress
- RNA Interference and Gene Delivery
University of Urbino
2025
University of Salerno
2020-2024
University of Bologna
2018-2024
Toscana Life Sciences
2016
Tuned Mass Dampers (TMDs) are traditionally employed in tall buildings to control displacements, typically featuring a low mass ratio. This study explores the potential of TMDs with significantly higher ratios for seismic retrofitting existing civil structures, an area that remains largely unexplored. The research investigates non-conventional exceptionally high ratios, which can be implemented by either elevating structure or utilizing part building's superstructure as tuning on isolators....
Dental pulp is an accessible source of multipotent mesenchymal stromal cells (MSCs). The perspective role dental stem (DPSCs) in regenerative medicine demands vitro expansion and vivo delivery which must deal with the safety issues about animal serum, usually required cell culture practice. Human platelet lysate (PL) contains autologous growth factors has been considered as valuable alternative to fetal bovine serum (FBS) cultures. optimum concentration be added such supplement highly...
Abstract Approximately 30% of ERα breast cancer patients relapse with metastatic disease following adjuvant endocrine therapies. The connection between acquisition drug resistance and invasive potential is poorly understood. In this study, we demonstrate that the type II keratin topological associating domain undergoes epigenetic reprogramming in aromatase inhibitors (AI)-resistant cells, leading to Keratin-80 (KRT80) upregulation. KRT80 expression driven by de novo enhancer activation...
Antibiotic resistance is creating enormous attention on the development of new antibiotic-free therapy strategies for bacterial diseases. Mesenchymal stromal stem cells (MSCs) are most promising candidates in current clinical trials and included several cell-therapy protocols. Together with well-known immunomodulatory regenerative potential MSC secretome, these have shown direct indirect anti-bacterial effects. However, low reproducibility standardization MSCs from different sources...
We have established an in vitro 3D system which recapitulates the human tracheo-bronchial mucosa comprehensive of pseudostratified epithelium and underlying stromal tissue. In particular, we reported that mature model, entirely constituted primary cells origin, develops key markers proper native tissue such as mucociliary differentiation epithelial sheet formation basement membrane. The infection pseudo-tissue with a strain NonTypeable Haemophilus influenzae results bacteria association...
Currently, the majority of cell-based studies on neurodegeneration are carried out two-dimensional cultured cells that do not represent residing in complex microenvironment brain. Recent evidence has suggested three-dimensional (3D) vitro microenvironments may better model key features brain tissues order to study molecular mechanisms at base neurodegeneration. So far, no drugs have been discovered prevent or halt progression neurodegenerative disorders. New therapeutic interventions can...
The petals of the saffron crocus (Crocus sativus L.) are considered a waste material in production, but may be sustainable source natural biologically active substances nutraceutical interest. aim this work was to study cardiovascular effects kaempferol and crocin extracted from petals. antiarrhythmic, inotropic, chronotropic petal extract (SPE), kaempferol, were evaluated through vitro biological assays. antioxidant activity investigated 2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA)...
Spent coffee grounds (SCGs), waste products of beverage production, are rich in organic compounds such as phenols. Different studies have demonstrated phenol beneficial effects counteracting neurodegenerative diseases. These diseases associated with oxidative stress and neuroinflammation, which initiates the degeneration neurons by overactivating microglia. Unfortunately, to date, there no pharmacological therapies treat these pathologies. The aim this study was evaluate phenolic content 4...
Type 1 diabetes mellitus (T1DM) is a complex metabolic disease characterized by massive loss of insulin-producing cells due to an autoimmune reaction. Currently, daily subcutaneous administration exogenous insulin the only effective treatment. Therefore, in recent years considerable interest has been given stem cell therapy and particular use three-dimensional (3D) cultures better reproduce vivo conditions. The goal this study provide reliable cellular model that could be investigated for...
Amniotic fluid stem cells (AFSCs) are characterized in vivo by a unique niche guarantying their homeostatic role the body. Maintaining functionality of ex for clinical applications requires continuous improvement cell culture conditions. Cellular redox status plays an important biology as long reactive oxygen species (ROS) concentration is finely regulated and adverse effects excluded. The aim this study was to investigate protective effect two antioxidants, sulforaphane (SF)...
Castanea sativa cultivation has been present in Mediterranean regions since ancient times. In order to promote a circular economy, it is of great importance valorize chestnut groves’ by-products. this study, leaves and spiny burs from twenty-four trees were analyzed by 1H NMR metabolomics provide an overview their phytochemical profile. The Orthogonal Projections Latent Structures Discriminant Analysis (OPLS-DA) performed on these data allowed us distinguish ‘Marrone’ ‘Castagna’, the latter...
Mesenchymal stem cells (MSC) make up less than 1% of the bone marrow (BM). Several methods are used for their isolation such as gradient separation or centrifugation, but these methodologies not direct and, thus, plastic adherence outgrowth magnetic/fluorescent-activated sorting is required. To overcome this limitation, we investigated use a new separative technology to isolate MSCs from BM; it label-free separates based solely on physical characteristics, preserving native properties, and...
Castanea sativa is very common in Italy, and the large amount of waste material generated during chestnut processing has a high environmental impact. Several studies demonstrated that by-products are good source bioactive compounds, mainly endowed with antioxidant properties. This study further investigates anti-neuroinflammatory effect leaf spiny bur extracts, together deepest phytochemical characterisation (by NMR MS) active biomolecules contained which resulted being more effective than...
Mesenchymal stromal/stem cells (MSCs) are multipotent with differentiation, immunoregulatory and regenerative properties. Because of these features, they represent an attractive tool for medicine cell-based therapy. However, MSCs may act as a reservoir persistent viruses increasing the risk failure MSCs-based therapies viral transmission, especially in immunocompromised patients. Parvovirus B19V (B19V) is common human pathogen that infects bone marrow erythroid progenitor cells, leading to...
The Second International StemNet (Federation of Stem Cell Research Associations) meeting took place on 18–20 October 2023 in Brescia (Italy), with the support University and Zooprophylactic Institute Lombardy Emilia Romagna. program was articulated nine sections: (1) Biomedical Communication Italy: Critical Aspects; (2) Next Generation Session; (3) Cell-Free Therapies; (4) Tips Tricks Valorisation; (5) Cells Cancer; (6) Veterinary Applications; (7) Clinical (8) Organoids 3D Systems; (9)...